Clinical trials: Central Nervous System Disease
Parkinson's Disease
MAPT Haploid H1b and the Damage of BBB in Dorsal Medulla Oblongata and Autonomic Dysfunction in PD
This study mainly explored the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of…
- Trial name
- NCT05471713
- Testing
- Autonomic dysfunction
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Stroke, Quality of Life
Effects of Two Home Ergonomics Programmes in Post-stroke Patients
The main objective of the clinical trial is to evaluate the effectiveness of two home ergonomics programmes, by reference to a control group, on functional capacity and quality of life in post-stroke patients.
- Trial name
- NCT03665220
- Testing
- Ergonomic adjustments, Kinesiotherapy plus ergonomic adjustments, Healthcare education
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad de Granada
Spastic Cerebral Palsy
Circuit Training in Children With Cerebral Palsy
The aim of our study is to reveal the results of circuit training to be applied to the children with Cerebral Palsy (CP) for improving their muscular strength and trunk control and also to determine their effects in terms of…
- Trial name
- NCT03529682
- Testing
- exercise, control group
- Where
- Cyprus
- Volunteers
- 62 people
- Sponsor
- Eastern Mediterranean University
Epilepsy, Epilepsy, Focal
A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.
The purpose of this study is to demonstrate that RWJ-333369 is safe and effective as add-on treatment of partial onset seizures.
- Conditions
- Epilepsy, Epilepsy, Focal, Seizure Disorder, Complex Partial Seizures
- Trial name
- NCT00425282
- Testing
- RWJ-333369
- Volunteers
- 566 people
- Sponsor
- SK Life Science, Inc.
Stroke
Upper Extremity Recovery Post Stroke Using Virtual Occupations
The purpose of this study is to explore the efficacy of the SaeboVR rehabilitation system for improving functional outcomes related to upper extremity motor recovery in stroke survivors. The specific objectives are: 1.
- Trial name
- NCT03886480
- Testing
- SaeboVR
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
Non-valvular Atrial Fibrillation (NVAF)
A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)
This study is planned to collect prospective data and evaluate the safety and effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in Indian patients with NVAF when used in clinical practice under…
- Trial name
- XARIN (NCT03887780)
- Testing
- Rivaroxaban (Xarelto,Bay 59-7939)
- Where
- India
- Volunteers
- 504 people
- Sponsor
- Bayer
Essential Tremor
1-Octanol to Treat Essential Tremor
This study will determine the optimal dose of 1-octanol that will safely reduce tremors in patients with essential tremor-a disorder in which the hands, and sometimes the head, shake involuntarily.
- Trial name
- NCT00016679
- Testing
- 1-Octanol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Central Nervous System Diseases
CKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)
The purpose of this study is to evaluate a pharmacokinetic drug interaction between D797 of D324 in healthy volunteers
- Trial name
- NCT03569579
- Testing
- Memantine Tab. 10mg, Memantine Tab. 10mg + Donepezil Tab. 10mg
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Cerebral Infarction, Cerebral Infarction Recovery
D-dimer Prognostic Marker of Cerebral Infarction After Revascularization Procedure
Cerebral infarction is the leading cause of acquired disability in adults. Absence of biological marker used in current practice and identified as a prognostic factor for recovery.
- Trial name
- D-Dimer (NCT04938479)
- Testing
- blood sample
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Spinal Cord Injury
BCI and FES for Hand Therapy in Spinal Cord Injury
This study will assess whether functional recovery of the hand muscles in patients with spinal cord injury is enhanced when electrical stimulation of the muscles is delivered actively by means of using the electroencephalography…
- Trial name
- NCT01852279
- Testing
- BCI-FES, Passive muscle stimulation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- NHS Greater Glasgow and Clyde
Stroke
Enhancing Prehospital Stroke Diagnosis
Current American Heart Association Guidelines recommend that stroke patients be promptly rescued and identified so that the accepting hospital can be alerted and prepared to receive and treat them promptly.
- Trial name
- AIPO (NCT06427746)
- Testing
- Standard, Video call, Video call + LARIO
- Where
- Italy
- Volunteers
- 2,197 people
- Sponsor
- Agenzia Regionale emergenza Urgenza
Alzheimer Disease
Semantic Recognition Task (SRT) in Alzheimer Disease
The goal of this study is to observe the outcomes of a semantic recognition task in Alzheimer Disease and discuss what this might add to clinical practice.
- Trial name
- SRT (NCT05711888)
- Testing
- Semantic Recognition Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Traumatic Brain Injury
Investigating How Sleep After Training Can Affect the Learning of a Motor Skill in Individuals With Brain Injury
Studies have shown that a period of sleep, even in the form of a daytime nap, after a period of training on a motor learning task can boost subsequent performance beyond that observed after an equal amount of time spent awake and…
- Trial name
- NCT04810442
- Testing
- Nap
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Brain Neoplasm
Clinical Study on 5-aminolevulinic Acid Hydrochloride (5-ALA) for Fluorescence-guided Resection of Malignant Gliomas
This study is planned to detect a dose-efficacy relationship between the chosen dose levels of MC506/1 and the extent and quality of fluorescence in the tumour core in patients with newly diagnosed malignant glioma.
- Trial name
- NCT02755142
- Testing
- Gliolan
- Volunteers
- 21 people
- Sponsor
- medac GmbH
Newly Diagnosed High-Grade Gliomas, Diffuse Intrinsic Pontine Glioma
A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas
The outcome for children with high-grade gliomas and diffuse intrinsic brainstem gliomas remains poor despite the use of multi-modal therapy with surgery, radiation therapy and chemotherapy.
- Trial name
- NCT00890786
- Testing
- Temozolomide, Bevacizumab, Irinotecan
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Osteopenia, Spinal Muscular Atrophy
Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions
Children with neuromuscular disabilities and limited ambulation are at significant risk for decreased bone mineral density (BMD) and increased incidence of fracture.
- Conditions
- Osteopenia, Spinal Muscular Atrophy, Cerebral Palsy, Muscular Dystrophy
- Trial name
- NCT02428673
- Testing
- Assisted Standing Treatment Program
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Gillette Children's Specialty Healthcare
Traumatic Brain Injury
Effects of Exercise on Memory in Healthy and Brain-Injured Individuals
Background: Research has shown that one exercise session may improve a person s ability to recall information they learned before the exercise.
- Trial name
- NCT01939769
- Testing
- Exercise - Low-intensity exercise, Exercise - High-intensity exercise
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Frail Elderly
Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults
The current study seeks to examine the prevalence of amyloid pathology, among patients referred to the Toulouse Geriatric Frailty Clinic presenting objective memory impairment.
- Trial name
- COGFRAIL (NCT03129269)
- Testing
- MRI and PET scan
- Where
- France
- Volunteers
- 344 people
- Sponsor
- University Hospital, Toulouse
Vagus Nerve Diseases, Epilepsy
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves.
- Conditions
- Vagus Nerve Diseases, Epilepsy, Vagus Nerve Autonomic Disorder
- Trial name
- EITsVNS (NCT05664854)
- Testing
- Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Parkinson's Disease (PD)
Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Benserazide
The purpose of this study is to determine the effect of three single oral doses of nebicapone (50 mg, 100 mg and 200 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled release…
- Trial name
- NCT02778594
- Testing
- BIA 3-202, levodopa 100 mg / benserazide 25 mg
- Where
- Portugal
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
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