Clinical trials: Central Nervous System Disease
Stroke
Effects of Unilateral Step Training on Gait and Balance in Stroke Patients
According to the definition proposed by the World Health Organization, "stroke is rapidly developing clinical signs of focal (or global) disturbance of cerebral function, with symptoms lasting 24 hours or longer, or leading to…
- Trial name
- NCT05449301
- Testing
- Rhythmic Auditory Stimulation, Treadmill Training, Unilateral Step Training
- Where
- Pakistan
- Volunteers
- 63 people
- Sponsor
- Riphah International University
Dementia With Lewy Bodies
Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies
Deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery.
- Trial name
- DEMENSTIM (NCT01340001)
- Testing
- Electrical stimulation of the nucleus basalis of Meynert
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Opioid Use Disorder
Mobile Peer Support for OUD Recovery
The COVID-19 pandemic puts individuals recovering from opioid use disorders (OUDs), an already vulnerable population, at increased risk of overdose due to decreased access to treatment, decreased social support, and increased…
- Trial name
- MPS (NCT05405712)
- Testing
- Mobile Phone App
- Where
- 2 sites in United States
- Volunteers
- 1,300 people
- Sponsor
- Brown University
Parkinsons Disease (PD), Anxiety
TMS in Anxiety-Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Anxiety in PD is common, has major effects on quality of life and contributes to increased disability.
- Trial name
- NCT06999330
- Testing
- Theta burst stimulation active coil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Chronic Pain, Spinal Cord Injury
Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury
The purpose of this study is to investigate the effects of Transcranial Direct Current Stimulation (tDCS) combined with watching a visual illusion on chronic pain due to spinal cord injury.
- Trial name
- NCT01404065
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Idiopathic Parkinson's Disease
Stalevo in Early Wearing-Off Patients
The purpose of this study is to demonstrate in patients with Parkinson's disease that, when compared to levodopa/carbidopa, Stalevo will delay the time from initiation of study drug to the time an increase in antiparkinsonian…
- Trial name
- SEWOP (NCT00125567)
- Testing
- Stalevo (levodopa/carbidopa/entacapone), Levodopa/carbidopa
- Where
- 19 sites in Denmark, Finland and 4 more
- Volunteers
- 223 people
- Sponsor
- Orion Corporation, Orion Pharma
Spinal Cord Injury, Neuropathic Pain
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.
- Trial name
- NCT01579500
- Testing
- Botulinum toxin type A, normal saline
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Intra Cerebral Hemorrhage, Stroke
Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment
A randomized controlled trial of ultra-early, minimally invasive, hematoma evacuation versus standard care within 8 hours of intracerebral hemorrhage.
- Trial name
- EVACUATE (NCT04434807)
- Testing
- Minimally invasive hematoma evacuation
- Where
- 13 sites in Australia
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Ischemic Stroke, Acute
The Effect of Ginkgolide on Clinical Improvement of Patients With Acute Ischemic Stroke
The aim of this study is to evaluate the safety and effectivity of Ginkgo diterpene lactone meglumine injection tn the treatment of acute ischemic stroke
- Trial name
- NCT05663307
- Testing
- Ginkgo diterpene lactone meglumine injection, Ginkgo diterpene lactone meglumine injection simulation, Aspirin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Alzheimer Disease, Amyotrophic Lateral Sclerosis
The Ontario Neurodegenerative Disease Research Initiative
The Ontario Neurodegenerative Disease Research Initiative (ONDRI) is a province-wide collaboration studying dementia and how to improve the diagnosis and treatment of neurodegenerative diseases including: Alzheimer's disease (AD)…
- Conditions
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson Disease
- Trial name
- ONDRI (NCT04104373)
- Testing
- Observational Cohort
- Where
- 12 sites in Canada
- Volunteers
- 522 people
- Sponsor
- Ontario Neurodegeneration Disease Research Initiative
Acute Disseminated Encephalomyelitis
ADAM'S Prognostic Markers
Acute Disseminated Encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder of the central nervous system that predominantly affects children.
- Trial name
- NCT07188194
- Volunteers
- 32 people
- Sponsor
- Assiut University
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Stroke
Non-invasive Measurement of Cerebral Dynamic Autoregulation
The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors.
- Trial name
- TOMCAT (NCT02442856)
- Testing
- Thigh Cuff
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pennsylvania
Stroke, Anosognosia
Improving Awareness for Spatial Neglect With tDCS
Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia.
- Conditions
- Stroke, Anosognosia, Neglect, Hemispatial
- Trial name
- ANOSO (NCT04845529)
- Testing
- transcranial direct current stimulation (tDCS)
- Volunteers
- 12 people
- Sponsor
- University of Geneva, Switzerland
Spinal Cord Injuries
Usability of the Adapted Rower for People With Spinal Cord Injury
The goal of this clinical trial is to examine usability of a locally built adaptive rower for people with spinal cord injury using an established and tested design. The main questions it aims to answer are: 1.
- Trial name
- NCT05959837
- Testing
- Adaptive Rowing Exercise
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of South Carolina
Cerebral Palsy
Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy
Cerebral palsy (CP) is a common childhood-onset disability associated with motor and cognitive impairments, however most research is focused on motor outcomes.
- Trial name
- NCT04273737
- Testing
- Amantadine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Migraine Disorders
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism…
- Trial name
- NCT05690737
- Testing
- Tai Chi training, Standard prophylactic medication
- Where
- 2 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Palsy
Allogeneic Umbilical Cord Blood Therapy in Children With CP
This open-label study aims to analyze cytokines related to clinical outcomes of allogeneic umbilical cord blood therapy for children with cerebral palsy.
- Trial name
- NCT02025972
- Testing
- Allogeneic umbilical cord blood therapy
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- MinYoung Kim, M.D.
Stroke, Hemiplegia
Rehabilitation of Early Stroke Patients Using an AFO: an RCT
Stroke is a major cause of disabilities worldwide. Stroke survivors commonly exhibit walking defects which lead to an altered, slow speed and asymmetric gait pattern.
- Trial name
- NCT01006772
- Testing
- Solid Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Strathclyde
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.