Clinical trials: Central Nervous System Disease
Alzheimer's Disease, Mild Cognitive Impairment
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
This is a first-in-human clinical trial to test whether a protein administered into the brain continuously by gene therapy, Brain-Derived Neurotrophic Factor (BDNF), will slow or prevent cell loss in the brains of people affected…
- Trial name
- NCT05040217
- Testing
- AAV2-BDNF Gene Therapy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mark Tuszynski
Growth Hormone Disorder, Pituitary Dwarfism
Somatropin (Norditropin) in Insulin-like Growth Factor (IGF) Deficient Children
This trial is conducted in the United States of America (USA). This is a 12 month study to determine if Norditropin is safe and effective in children with IGF deficiency.
- Trial name
- NCT00102817
- Testing
- somatropin
- Where
- 27 sites in United States
- Volunteers
- 149 people
- Sponsor
- Novo Nordisk A/S
Cerebral Injury
Functional Near Infrared Spectroscopy in Adult Surgery
Brain injury is a serious problem after cardiac surgery. Brain injury can become evident in the form of stroke and cognitive dysfunction after surgery.
- Trial name
- NCT04574440
- Testing
- multichannel fNIRS monitoring
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China
1. To investigate the biomarkers of MND/FTD spectrum disease 2. To explore the possible pathogenesis of MND/FTD
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Motor Neuron Disease
- Trial name
- NCT04961450
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Peking University Third Hospital
Post-Traumatic Headache
Behavior Therapy vs Education for Persistent Headache After Mild TBI
This study will test a new treatment, called Headache reprocessing, for persistent post-traumatic headache. The new treatment will be compared to a headache education intervention.
- Trial name
- NCT07229391
- Testing
- Headache reprocessing, Headache education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Stroke
Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
People with post-stroke aphasia are left with some degree of chronic deficit for which current rehabilitative treatments are variably effective.
- Trial name
- NCT02901574
- Testing
- Anodal or Cathodal tDCS, Computerized naming therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Tic Disorder
Scalp Acupuncture Treatment for Chronic Tic Disorders in Children
The goal of this clinical trial is to learn if scalp acupuncture works to treat chronic tic disorders (CTD) in children. It will also learn about the safety of scalp acupuncture.
- Trial name
- NCT06924918
- Testing
- Scalp Acupuncture Treatment, Tuina Treatment Group
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Children's Hospital of Fudan University
Epilepsy (Treatment Refractory)
Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring
TRACE is a record-only study evaluating subgaleal EEG (sgEEG) recorded concurrently with standard-of-care stereoelectroencephalography (SEEG) in adults with drug-resistant epilepsy undergoing inpatient epilepsy monitoring.
- Trial name
- TRCE (NCT07821697)
- Testing
- EEG Record only
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Adraxe Corp.
Dementia
A Phone Intervention for Family Dementia Caregivers in Vietnam
This is a cluster randomized controlled trial to examine the feasibility, acceptability, and preliminary efficacy of the phone version of REACH VN, a psychosocial culturally adapted Alzheimer's family caregiving intervention, to…
- Trial name
- NCT05481320
- Testing
- REACH VN Phone Intervention, Enhanced Control
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Stroke
Action Observation Treatment on Motor Function in Upper Limb of Patients With Chronic Stroke
To determine the effects of action observation treatment on motor functions in upper limb of patients with chronic stroke
- Trial name
- NCT05084820
- Testing
- Action observation treatment, conventional treatment
- Where
- Pakistan
- Volunteers
- 14 people
- Sponsor
- Riphah International University
Alzheimer's Disease, Mild Cognitive Impairment
Alzheimer's Disease Core Center
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders
- Trial name
- ADCC (NCT01421420)
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Migraine, Headache
Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine.
The purpose of this study is to determine whether a fixed-dose combination of naratriptan 2,5 mg + naproxen 500 mg is effective and safe compared each monotherapy for the acute treatment of migraine.
- Trial name
- Copérnico (NCT01726920)
- Testing
- naratriptan + naproxen, naratriptan, naproxen
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Drug Resistant Epilepsy
Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy
Effect of oral magnesium sulfate (Mg) supplementation will be studied. Children with drug resistant idiopathic epilepsy following up in Pediatric Neurology Clinic, Ain Shams University, will be randomized to either Mg add-on…
- Trial name
- NCT02982824
- Testing
- Magnesium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Brain Injuries
Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury
To investigate the effect of Bevacizumab on asymptomatic radiotherapy-induced brain injury patients with head and neck cancer.
- Trial name
- BRAIN (NCT05303259)
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Patent Foramen Ovale
Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches
The foramen ovale, a kind of physiologic channel in the interatrial septum in the heart at embryonic stage, is closed normally at 5-7 months after birth.
- Trial name
- NCT02777359
- Testing
- the transcatheter closure of PFO
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Stroke
Predictive Factors Of Acute Ischemic Stroke Outcome in Adult
Stroke is a devastating disease that affects 15 million patients worldwide each year, resulting in death in about one-third of patients and severe disability in two-thirds of the survivors.
- Trial name
- NCT03700879
- Testing
- MRI,MRA,Carotid ,vertebrobasilar and Transcranial Doppler
- Volunteers
- 50 people
- Sponsor
- Assiut University
Progressive Supranuclear Palsy
A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressive Supranuclear Palsy (PSP)
The purpose of this study was to assess efficacy, safety, tolerability, and pharmacokinetics of ABBV-8E12 in participants with progressive supranuclear palsy (PSP).
- Trial name
- NCT02985879
- Testing
- ABBV-8E12
- Where
- 66 sites in United States, Australia and 6 more
- Volunteers
- 378 people
- Sponsor
- AbbVie
Cardiac Arrest (CA), Cerebrospinal Fluid
Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.
- Conditions
- Cardiac Arrest (CA), Cerebrospinal Fluid, Multiomics, Hypoxic-Ischemic Brain Injury
- Trial name
- PCABI-OMICS (NCT07481396)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chungnam National University Hospital
Brain and Central Nervous System Tumors
Temozolomide Plus Thalidomide in Treating Patients With Recurrent or Progressive Brain Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of cancer by stopping blood flow to the tumor.
- Trial name
- NCT00006358
- Testing
- temozolomide, thalidomide
- Where
- 11 sites in United States
- Volunteers
- 44 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
AD, Early Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of TTYP01 Tablets in Early Symptomatic Alzheimer's Disease
This is a multicenter, randomized, double-blind, placebo-controlled parallel Phase II core period study to evaluate the efficacy and safety of TTYP01 Tablets in early symptomatic AD (Mild cognitive impairment [MCI] due to AD, or…
- Trial name
- NCT07252440
- Testing
- TTYP01 tables 60mg, TTYP01 tables 90mg, TTYP01 tables 0mg
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Auzone Biological Technology Co., Ltd.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.