Clinical trials: Central Nervous System Disease
Alzheimer's Disease
Open-Label Extension Study Of Rosiglitazone XR As Adjunctive Therapy In Subjects With Mild-to-Moderate Alzheimers
This is a Phase III, multicenter, open-label extension, single-group study in male and female outpatients with mild-to-moderate Alzheimer's disease (AD) who have completed either AVA102670 or AVA102672.
- Trial name
- NCT00490568
- Testing
- Rosiglitazone XR
- Where
- 272 sites in United States, Argentina and 27 more
- Volunteers
- 1,461 people
- Sponsor
- GlaxoSmithKline
Gaucher Disease
A Phase III Trial to Assess the Safety and Efficacy of Plant Cell Expressed GCD in Patients With Gaucher Disease
Gaucher disease, the most prevalent lysosomal storage disorder, is caused by mutations in the human glucocerebrosidase gene (GCD) leading to reduced activity of the lysosomal enzyme glucocerebrosidase and thereby to the…
- Trial name
- NCT00376168
- Testing
- Plant cell expressed recombinant glucocerebrosidase (prGCD)
- Where
- 11 sites in United States, Canada and 6 more
- Volunteers
- 32 people
- Sponsor
- Pfizer
Stair Climbing, Instrumentation
Implementation and Validation of Instrumented Stair Climb Test
The aim of this study is to design an instrumented test for the evaluation of the climb of stairs. In particular, the main purpose is to characterize and compare the performance of subjects, both pediatrics and adults, with…
- Conditions
- Stair Climbing, Instrumentation, Test
- Trial name
- SCTS (NCT06999850)
- Testing
- Instrumented Stair Climb Test, Walk Test, Repaeted Instrumented Stair Climb Test
- Where
- 3 sites in Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Dementia
Doll Therapy in Dementia
Behavioral and psychologic symptoms in dementia (BPSD) are frequent and represent a burden for patients and caregivers, the use of a first line non-pharmacologic approach is highly recommended.
- Trial name
- DESCRIBE (NCT04920591)
- Testing
- doll treatment
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson Disease
Attentional Focus and Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease (PD)
Attention may influence the motor performance and frontal activity. This study will examine the effect of different attentional focus: internal, external and divided attention (dual task) on prefrontal cortical activation (fNIRS)…
- Trial name
- AttPark (NCT05073874)
- Testing
- Functional Near-Infrared Spectroscopy (fNIRS)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Glioblastoma, Gliosarcoma
Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma
The goal of this clinical research study is to find the highest tolerable dose of sorafenib that can be given in combination with temozolomide. The safety of this combination will also be studied.
- Trial name
- NCT02599090
- Testing
- Temozolomide, Radiation, Sorafenib
- Sponsor
- M.D. Anderson Cancer Center
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma
Bendamustine Hydrochloride in Treating Patients With Recurrent or Progressive Anaplastic Glioma
This phase II trial studies how well bendamustine hydrochloride works in treating patients with anaplastic glioma or glioblastoma that has come back (recurrent) or growing, spreading or getting worse (progressive).
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma
- Trial name
- NCT00823797
- Testing
- Bendamustine Hydrochloride, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Washington
Spinal Cord Injuries
The Effect of Functional Electrical Stimulation Cycling Ergometry in Addition to Robotic Rehabilitation
Spinal cord injury (SCI) is a devastating neurological condition resulting from either traumatic or non-traumatic causes, leading to loss of motor, sensory, and autonomic functions in individuals.
- Trial name
- NCT06541197
- Testing
- Robotic rehabilitation combined with Functional Electrical Stimulation (FES) bicycle ergometry group, Robotic rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Raynaud Disease, Raynaud Phenomenon
Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon
Patients with Raynaud's disease have an increased tendency of chest pain and migraine, and studies indicate that the disease might be associated with increased cardiovascular morbidity and mortality.
- Conditions
- Raynaud Disease, Raynaud Phenomenon, Hand and Arm Vibration Syndrome, Diabetes Mellitus
- Trial name
- RaynAUT (NCT03094910)
- Testing
- Examination of vibration perception threshold in fingertips, Ewing's tests, Tilt table test
- Where
- Denmark
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Traumatic Brain Injury
Clinical Evaluation of the i-STAT TBI Test
The goal of this study is to evaluate the i-STAT TBI test to assist determining the need for a computed tomography (CT) scan in patients with suspected mild traumatic brain injury (TBI).
- Trial name
- NCT04171960
- Testing
- Blood draw, Outcome assessments
- Where
- 21 sites in United States
- Volunteers
- 1,106 people
- Sponsor
- Abbott Point of Care
Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases
Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)
The work of Nau et. al (Nau KL, Bromberg MB, Forshew DA, Katcha Vl. Individuals with amyotrophic lateral sclerosis are in caloric balance despite losses in mass.
- Trial name
- NCT00714220
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Lyme Borreliosis
A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults
The purpose of this study is to learn about the safety and effects of the Lyme disease vaccine (called VLA15) when given at different time points.
- Trial name
- NCT07226882
- Testing
- VLA15
- Where
- 6 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cerebral Infarction, Chinese Herbal Medicine
Th Tl Xb Prescription on Reprogramming of Lipid Metabolism and Endothelial Injury for Cerebral Infarction Patients
This study is a prospective, open-label, randomized control trial. It is planning to include 160 cerebral infarction patients which will be randomized in a 1﹕1 fashion to receive Chinese herbal medicines combined basic medicine…
- Conditions
- Cerebral Infarction, Chinese Herbal Medicine, Clinical Trial, Lipid Metabolism Disorder
- Trial name
- NCT06549582
- Testing
- Taohong Tongluo Xiaoban Prescription, Fundamental medical treatment
- Volunteers
- 160 people
- Sponsor
- Yan Zhu
Ischemic Stroke, Hemorrhagic Stroke
A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad (iCOOL 3)
Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease.
- Trial name
- iCOOL 3 (NCT01584180)
- Testing
- Cold crystalloid infusions, 0.9%NaCl or Ringer's, EMCOOLS Brain.Pad
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Ataxia, Chorea
Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia
Ataxia-Telangiectasia A-T is a neurodegenerative disorder of the cerebellum, manifesting with ataxia, as well as extrapyramidal features.
- Conditions
- Ataxia, Chorea, Dystonia, Parkinsonism
- Trial name
- NCT00950196
- Testing
- amantadine sulphate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Cerebral Palsy (CP)
Awareness Among Physiotherapists About Effectiveness of Sensory Integration Therapy on Cerebral Palsy Population.
The study is to interrogate the awareness level of physiotherapists that are working in the region of KHYBER PAKHTUNKHWA, to access whether they know about sensory integration therapy or they use it for the patients of cerebral…
- Trial name
- NCT06748196
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Arthritis, Cancer
MoveStrong at Home: A Feasibility Study of a Model for Remote Delivery of Functional Strength and Balance Training Combined With Nutrition Education for Older Pre-frail Adults.
Sufficient muscle strength helps to get out of a chair and can prevent falls. Up to 30% of older adults experience age-related loss of muscle strength, which can lead to frailty and health instability.
- Conditions
- Arthritis, Cancer, Cardiovascular Diseases, Chronic Lung Disease
- Trial name
- NCT04663685
- Testing
- Exercise program, Nutrition education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Waterloo
Post-Traumatic Headache
Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic Headache
To investigate whether sildenafil (phosphodiesterase 5 inhibitor) induces migraine-like headache in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
- Trial name
- NCT05669885
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Essential Tremor
A Safety/Efficacy Trial of Zonisamide for Essential Tremor
The purpose of this pilot study is to obtain information whether the medication zonisamide reduces tremor in persons with essential tremor and is well tolerated.
- Trial name
- NCT00223743
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Greater Los Angeles Healthcare System
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