Clinical trials: Central Nervous System Disease
Elderly Patients, Cognitive Disorder
Psychometric Validation of the "Antillanisée" Version of the Mini Mental State Examination (MMSEa)
The main objective of the study is to analyze the psychometric properties of the "antillanisée" version of the Mini Mental State Examination (MMSEa).
- Conditions
- Elderly Patients, Cognitive Disorder, Alzheimer Disease
- Trial name
- MMENSEA (NCT03324711)
- Testing
- "Antillanisée" Mini Mental State Examination (MMSEa)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital Center of Martinique
Alzheimer Disease
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease. Additional participants will be enrolled to an addendum safety cohort.
- Trial name
- NCT04437511
- Testing
- Donanemab
- Where
- 274 sites in United States, Australia and 7 more
- Volunteers
- 1,736 people
- Sponsor
- Eli Lilly and Company
Sepsis
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown.
- Trial name
- NCT00410111
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Ischemic Stroke
Acute Ischemic Stroke Interventional Study
To assess safety of single IV (bolus + infusion) doses of ACT017 in patients with an acute ischemic stroke in addition to best emergency standard of care (including fibrinolysis by rtPA with or without added thrombectomy), with a…
- Trial name
- ACTIMIS (NCT03803007)
- Testing
- Intravenous ACT017 1000 mg
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Acticor Biotech
Cerebral Palsy, GORD
Gastro-oesophageal Reflux and NeuroDisability (Cerebral Palsy) in CHILDren
This study assesses the content validity of the PGSQ for parents/carer of children with cerebral palsy and GORD, including features such as readability, face validity and acceptability for completion.
- Conditions
- Cerebral Palsy, GORD, Pediatrics, GERD in Children
- Trial name
- GRANDCHILD (NCT04293107)
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Poole Hospital NHS Foundation Trust
Traumatic Brain Injury
The Research for New Clinical Diagnostic Strategy of Specific Biomarkers for Traumatic Brain Injury
Traumatic brain injury (TBI) is the most common type of nerve injury and it severely endangers the public health. It is necessary to accurately measure the early neurological function of brain injury for monitoring its prognosis…
- Trial name
- NCT03976492
- Testing
- diagnostic of specific biomarkers
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Baiyun Liu
Benign Epilepsy With Centrotemporal Spikes
18F-FDG PET Imaging Analysis of Antiepileptic Drug Response in BECTS
This original article is a novel investigation on the metabolic characteristics of different patterns of antiepileptic drug (AED) responses in benign epilepsy with centrotemporal spikes (BECTS) patients using 18F-FDG PET imaging.
- Trial name
- NCT04357236
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke
Early Antiplatelet for Minor Stroke Following Thrombolysis (EAST)
The current guideline recommends to give antithrombotic treatment 24 hours after intravenous thrombolysis in acute ischemic stroke.
- Trial name
- NCT05193071
- Testing
- Aspirin 100mg; Clopidogrel 300mg
- Where
- 2 sites in China
- Volunteers
- 1,022 people
- Sponsor
- General Hospital of Shenyang Military Region
Migraine
Long-Term Extension Study With Eptinezumab as Preventive Treatment in Participants With Migraine in Japan
This study is an open label extension study, which means that the participants from the Lead-in Study 19140A (NCT04921384) can join this study, if they meet the study Eligibility Criteria, and continue to receive the study drug…
- Trial name
- NCT05064371
- Testing
- Eptinezumab
- Where
- 17 sites in Japan
- Volunteers
- 160 people
- Sponsor
- H. Lundbeck A/S
Stroke
Gait Control of Stroke Patients Using Visual Feedback
The purpose of this study is to determine the possibility of gait pattern change via visual feedback among patients with stroke. Also, the optimal visual feedback would be chosen from this study.
- Trial name
- NCT02029664
- Testing
- Visual distortion increment based on the gait pattern
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Rehabilitation Center, Seoul, Korea
Aortic Valve Stenosis, Stroke
Oxygenation of the Cerebrum and Cooling During Transcatheter Aortic Valve Implantation (TAVI) Procedures - Part II
The aim of this study is to assess the possible neuroprotective effects of cooling (targeted cooling of the brain to 33°C) during Transcatheter Aortic Valve Implantation (TAVI) procedures.
- Trial name
- NCT01822964
- Testing
- targeted brain cooling (33°C) by RhinoChill device
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Stroke
Physiotherapy and Action-Observation Therapy: An Integrated Approach for Upper Limb Impairment in Subacute Stroke
Motor impairment is one of the most common result of a stroke, which causes disability and difficulties in activities of daily living. This motor impairment can concern the upper limb or the lower limb, or both.
- Trial name
- PHOENICS (NCT04560764)
- Testing
- Virtual Reality, Action Observation Therapy, Landscape video
- Where
- Italy
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinson Disease
Expanded Access Using Allogeneic Bone-marrow Derived Human Mesenchymal Stem Cells (Allo-hMSC) for a Individual Parkinson's Disease Subject
This is a expanded access use of allogeneic bone marrow-derived mesenchymal stem cells for a single subject with moderate Parkinson's disease that has progressed.
- Trial name
- NCT06798064
- Testing
- Allogeneic bone marrow-derived mesenchymal stem cells
- Where
- United States
- Sponsor
- Mya Schiess
Stroke, Intracranial Atherosclerotic Stenosis
SeQuent ® Please CIS for the Treatment of INtracranial Atherosclerotic Stenosis
This study is aiming to evaluate the safety and efficacy of SeQuent® Please CIS in the endovascular treatment of symptomatic intracranial atherosclerotic stenosis and restenosis after interventional therapy.
- Trial name
- SPINAS (NCT06047964)
- Testing
- DCB, POBA
- Where
- 9 sites in China
- Volunteers
- 281 people
- Sponsor
- B. Braun Medical International Trading Company Ltd.
Spinal Cord Injury
Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD
SATURN investigates the promising role of NeuroAiD in patients with spinal cord injury and will provide important information on the feasibility of conducting larger controlled trials.
- Trial name
- SATURN (NCT02537899)
- Testing
- NeuroAiD
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Moleac Pte Ltd.
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Stroke
Study on the Accuracy of Determining the Responsible Vessel in Medium Vessel Occlusive Stroke Based on Multi-type CT Evaluation
To evaluate the accuracy of diagnosing the qualifying artery in patients with medium vessel occlusion stroke based on multimodal CT
- Trial name
- NCT07347587
- Where
- China
- Volunteers
- 622 people
- Sponsor
- Xuanwu Hospital, Beijing
Glioblastoma, Glioblastoma Multiforme
Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial
This research is being done to find out if the study drug (posaconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing.
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Glioblastoma Multiforme, Adult
- Trial name
- NCT04825275
- Testing
- Posaconazole Pill
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Milton S. Hershey Medical Center
Alzheimer Disease
Long-term Efficacy and Safety Study of GV-971
Sodium Oligomannate Capsules (GV-971) has been approved for treatment of mild to moderate Alzheimer's disease and improving the cognitive function of patients.
- Trial name
- NCT05181475
- Testing
- Sodium Oligomannate Capsules (GV-971)
- Where
- 40 sites in China
- Volunteers
- 800 people
- Sponsor
- Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
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