Clinical trials: Central Nervous System Disease
Aneurysm, Intracranial
US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
The purpose of this trial is to gather data on the safety and effectiveness of the Contour /Contour 021 System in the treatment of wide-necked bifurcated saccular, intracranial aneurysms for submission to FDA in support of a…
- Trial name
- NECC (NCT04852783)
- Testing
- Contour Neurovascular System
- Where
- 20 sites in United States
- Volunteers
- 250 people
- Sponsor
- Cerus Endovascular, Inc.
HTLV-I-associated Myelopathy
The HAM Infliximab Study
An open-label, non-randomised, uncontrolled, proof-of-concept study of eight patients with 'definite' HTLV-I-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
- Trial name
- HAM06 (NCT00823641)
- Testing
- Infliximab
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Stroke
Metrological Characteristics of the Inertial Unit "FOX HiKoB©" in Comparison With the Reference System for the Adaptive Trigger System "Functional Electrical Stimulation" of Foot Elevators in Hemiplegic Post-stroke Patients
The main objective of this study is to evaluate the metrological characteristics of the data processing algorithms from inertial sensors (FOX © HiKoB) for the reconstruction of movement relative to the reference system (VICON)…
- Trial name
- MASEA 2 (NCT02598154)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stroke
R01.Aim 2.Study 1: IsoReach
To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke.
- Trial name
- NCT06656754
- Testing
- Isometric Reaching
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Development of a Model of Shoulder Pain Following Spinal Cord Injury
This study will investigate the progression of musculoskeletal (shoulder muscle flexibility, muscle strength, movement coordination, and rotator cuff health) and psychosocial (fear of movement, pain catastrophizing) impairments…
- Trial name
- NCT03137394
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Drexel University
Migraine
Effect of Osteopathic Intervention on Migraine
Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia.
- Trial name
- NCT07542340
- Testing
- Osteopathic Intervention Protocol
- Volunteers
- 45 people
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Fabry Disease
Safety, Efficacy, & PK of PRX-102 in Patients With Fabry Disease Administered Intravenously Every 4 Weeks
This open-label switchover study will assess the safety, efficacy, and pharmacokinetics of pegunigalsidase alfa (PRX-102) 2 mg/kg administered every 4 weeks for 52 weeks in Fabry patients previously treated with ERT: agalsidase…
- Trial name
- BRIGHT (NCT03180840)
- Testing
- Pegunigalsidase alfa
- Where
- 14 sites in United States, Belgium and 5 more
- Volunteers
- 30 people
- Sponsor
- Protalix
Spinal Cord Injury, Able Bodied
Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury
Spinal cord injury (SCI) is a highly debilitating pathology, associated with the loss of sensorimotor functions, autonomy and quality of life.
- Conditions
- Spinal Cord Injury, Able Bodied, Traumatic Spinal Cord Injuries, Paraplegia, Spinal
- Trial name
- NCT07732868
- Testing
- Brain-Machine Interface
- Where
- 2 sites in Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- José Gabriel da Silva Figueiredo
Stroke, Acute, Stroke, Ischemic
HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN)
This study aims to address the existing clinical challenges by introducing high-resolution magnetic resonance vessel wall imaging (HR-MRI), an advanced imaging technology, to achieve precise etiological classification in patients…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Cerebral Infarction
- Trial name
- NCT07379190
- Testing
- Tirofiban, dual antiplatelet therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Weifang Medical University
Cerebral Palsy
Development of a Remote Therapy Protocol for Upper Limb Function Enhancement in Children With Cerebral Palsy
The perpose of this study: Development and demonstration of a teletherapy protocol to improve upper limb function in children with cerebral palsy.
- Trial name
- NCT06272760
- Testing
- Home-based hand-arm bimanual intensive training (Tele-HABIT)
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Hemiplegia, Subacute Stroke
Neurodevelopmental Technique Versus Mirror Therapy in Sub-acute Stroke Patients
As neurodevelopmental technique and mirror therapy had different effects on lower limb coordination, functions and ambulation. Both had proven to be helpful in the stroke patients to gain functional independency.
- Conditions
- Hemiplegia, Subacute Stroke, Stroke Rehabilitation
- Trial name
- NDTVSMT (NCT07742020)
- Testing
- Neurodevelopmental Technique (NDT), Mirror Therapy (MT)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Parkinson Disease
Effects of Action Observation Training and Motor Imagery Delivered by Telerehabilitation in Patients with Parkinson's Disease
The goal of this clinical trial is to investigate the efficacy on motor and postural tasks of Action Observation Training (AOT) and Action Observation combined with Motor Imagery (AOMI) delivered by telerehabilitation in patients…
- Trial name
- TeleAOTPD (NCT06814782)
- Testing
- Action Observation Training, Action Observation and Motor Imagery, Exercise
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Alzheimer's Disease
CNS and Plasma Amyloid-Beta Kinetics in Alzheimer's Disease
Alzheimer's disease (AD) is the most common cause of dementia and currently has no disease modifying treatments or simple accurate diagnostic tests.
- Trial name
- NCT02021682
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimers Disease
A Postmarketing Study of LEQEMBI in Participants With Alzheimer's Disease
The primary purpose of this study is to evaluate the efficacy of LEQEMBI in participants with early Alzheimer's disease (AD) indicated per Canada Product Monograph (APOE4 non-carriers and heterozygotes; indicated population)…
- Trial name
- NCT07864623
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Eisai Inc.
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Cervicogenic Headache
"Effectiveness of Kaltenborn Mobilization Techniques Versus Maitland Mobilization on Management of Cervicogenic Headache
EFFECTIVENESS OF KALTENBORN MOBILIZATION TECHNIQUES VERSUS MAITLAND MOBILIZATION ON MANAGEMENT OF CERVICOGENIC HEADACHE
- Trial name
- Effectiveness (NCT07820280)
- Testing
- Maitland mobilization, Kaltenborn
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Ibadat International University, Islamabad
Brain and Nervous System, Eye and Orbit
Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma
The primary objective of Stage 1 is to evaluate the safety of nivolumab consolidation after completion of HD-MTX containing induction chemotherapy in older subjects with PCNSL in terms of a tolerated dose (based on dose-limiting…
- Trial name
- NCT04022980
- Testing
- Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Cerebral Palsy, Functional Balance
Effects of Virtual Reality on Functional Balance in Children With Cerebral Palsy (GMFCS III-IV)
This study proposes a randomized clinical trial to evaluate the effectiveness of an immersive virtual reality (VR)-based rehabilitation intervention on functional balance in children and adolescents (5-20 years) with cerebral…
- Trial name
- NCT07078279
- Testing
- immersive virtual reality intervention with Meta Quest 3, Intervention with Conventional Balance Physical Therapy
- Volunteers
- 40 people
- Sponsor
- Bartolome Puerta Arroyo
Acute Ischemic Stroke
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the…
- Trial name
- ATILA (NCT05225961)
- Testing
- Tirofiban, Acetylsalicylic acid
- Where
- 13 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Parkinson's Disease
Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics
The main treatment for Parkinson's disease is a medication called levodopa. Levodopa has to be absorbed from the gut and travel to the brain to work, but a naturally occurring enzyme in the lining of the stomach, called dopamine…
- Trial name
- NCT07793461
- Testing
- Levodopa (L-dopa)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
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