Clinical trials: Central Nervous System Disease
Alzheimer's Disease
OmegAD (Omega-3 and Alzheimer's Disease)
Memory loss and difficulties with thinking associated with Alzheimer's disease (AD) may be due to a deficiency in the brain of a fatty acid named DHA.
- Trial name
- NCT00211159
- Testing
- EPAX 1050TG
- Where
- Sweden
- Volunteers
- 204 people
- Sponsor
- Karolinska University Hospital
Alzheimer's Disease
Usability Study of Spaced Retrieval Exercise Using Mobile Devices for Alzheimer's Disease Rehabilitation
The focus of this work is to explore the use of modern mobile technology to enable people with Alzheimer's disease to improve their abilities to perform activities of daily living and hence to promote independence and…
- Trial name
- NCT02005380
- Testing
- Text-based task, Graphic-based Task
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- German-Jordanian University
Brain Neoplasms, Adult Brain Tumor
Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multiparametric Resonance Magnetic Imagery (RMI) in Initial Exploration of Glial Tumors
For patient having a brain tumor, RMI is the standard exam for tumor characterization and determines initial surgery. The aim of this study is to assess if PET could provide additional information that could have an impact on…
- Trial name
- GLIROPA (NCT03525080)
- Testing
- PET imagery
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Center Eugene Marquis
Migraine Headache
Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults
A Phase I clinical trial to compare the bioavailability of dihydroergotamine mesylate (DHE) following a single dose administration of INP104 (DHE administered by I123 Precision Olfactory Delivery (POD) Device Nasal Spray) to that…
- Trial name
- NCT03401346
- Testing
- INP104, Dihydroergotamine Mesylate (DHE), Migranal Nasal Spray
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Gastrointestinal Dysfunction, Malnutrition
Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients
This is a prospective two-center observational cohort study in adult patients undergoing major abdominal and/or pelvic oncologic surgery with pre-existing malnutrition.
- Conditions
- Gastrointestinal Dysfunction, Malnutrition, Delirium - Postoperative, Abdominal Neoplasm
- Trial name
- GIDNUT (NCT07622888)
- Testing
- Serotonin (e.g., serotonin adipinate), Standard Prokinetic Therapy (excluding serotonin)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Arma Ltd.
Acute Ischemic Stroke
Effect of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Patients With Intravenous Thrombolysis (SRICDCA-IVT)
The purpose of this study is to determine the effect of serial remote ischemic conditioning on dynamic cerebral autoregulation in patients with intravenous thrombolysis with alteplase.
- Trial name
- SRICDCA-IVT (NCT05550103)
- Testing
- Remote ischemic conditioning, Standard medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yi Yang
Peer Group
Longitudinal Observation of NHS Staff Wellbeing Following Introduction of the I-care Peer Support App
The coronavirus pandemic has had demonstrable impact upon healthcare workers. For healthcare workers this has meant disruption to vital access to peer support networks.
- Trial name
- I-Care (NCT04809961)
- Testing
- I-care app
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southampton
Encephalitis, Central Nervous System Infections and Inflammations
Brazil ICU Encephalitis Surveillance
Our proposal is to develop a sentinel syndromic surveillance strategy to identify encephalitis cases possibly related to emerging pathogens admitted to ICUs in Brazil.
- Conditions
- Encephalitis, Central Nervous System Infections and Inflammations, Intensive Care Neurological Disorder, Prognosis
- Trial name
- NCT05370573
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 451 people
- Sponsor
- D'Or Institute for Research and Education
Spatial Neglect, Stroke
Virtual Reality for Neglect Diagnostics
Compared to the classical "paper and pencil"-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.
- Trial name
- KMS-Neglect (NCT01399073)
- Testing
- virtual reality setup, paper and pencil tests, c-mri
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stroke, Depression
Poststroke Depression of Clinical Trial Registration
The investigators aim to explore the relationship between gut microbiota composition and earlier poststroke depression via 16S rRNA sequencing.
- Trial name
- IFEPSDAIS (NCT03863951)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Epilepsies, Partial
Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation of Refractory Epilepsy
Drug resistant epilepsy is best managed by surgery. The goal of presurgical evalution is to correctly identify the epileptogenic zone, defined by the extent of cortical tissue that needs to be removed is order to achieve seizure…
- Trial name
- EPILOG (NCT03882151)
- Testing
- electrical source imaging
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Episodic Cluster Headache, Chronic Cluster Headache
A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache
The main purpose of this study is to assess the long-term safety and tolerability of galcanezumab administered up to once monthly in participants with episodic or chronic cluster headache who have completed study I5Q-MC-CGAL…
- Trial name
- NCT02797951
- Testing
- Galcanezumab
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 165 people
- Sponsor
- Eli Lilly and Company
Onchocercal Subcutaneous Nodule, Epilepsy
Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study
This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy.
- Conditions
- Onchocercal Subcutaneous Nodule, Epilepsy, Virus
- Trial name
- NCT05868551
- Testing
- nodulectomy
- Where
- South Sudan
- Volunteers
- 40 people
- Sponsor
- Universiteit Antwerpen
Cerebral Palsy (CP), Reliability and Validity
Dubousset Functional Test: An Investigation of Its Validity and Reliability in Children With GMFCS I-II Spastic Cerebral Palsy
the investigators hypothesize that over time, it may lead to loss of functional capacity in children with CP. In this context, our study aims to examine the validity and reliability of the four-component Dubousset Functional Test…
- Conditions
- Cerebral Palsy (CP), Reliability and Validity, Functional Test, Gross Motor Function Classification System (GMFCS) Level I,II
- Trial name
- NCT06831591
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Inonu University
Neuromyelitis Optica, Myelitis, Transverse
A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease)
Neuromyelitis optica (NMO) is a severe demyelinating disease that selectively involves the optic nerves and the spinal cord but usually spares the brain. NMO is considered to have a B cell induced pathogenesis.
- Conditions
- Neuromyelitis Optica, Myelitis, Transverse, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous System
- Trial name
- NCT00304291
- Testing
- Mitoxantrone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- State University of New York at Buffalo
Post Dural Puncture Headache
Comparison of Acetaminophen With Aminophylline and Aminophylline With Dexamethasone for Prophylaxis of PDPH in Patients With History of PDPH.
It is hypothesized that there is a difference between intravenously administered aminophylline with intravenous acetaminophen and intravenously administered aminophylline with dexamethasone for prevention of and reducing severity…
- Trial name
- PDPH (NCT07528118)
- Testing
- Inj Aminophylline 100mg with Inj Acetaminophen 1000mg in 100ml Normal Saline, Inj Aminophylline 100mg , with 0.1mg/kg Dexamethasone in 100ml Normal Saline
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Sargodha Medical College
Respiratory Muscle, Pulmonary Function Test
Ultrasonographic Evaluation of Respiratory Muscles in Stroke Patients
Ultrasonographic evaluation of respiratory muscle thickness in stroke patients, determination of its correlation with pulmonary function test (PFT) , and the first evaluation method to determine respiratory rehabilitation goals…
- Trial name
- NCT05093491
- Testing
- Spirometry and ultrasonography in stroke group, Spirometry and ultrasonography in healthy group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Identification of Brain Injury Using Portable MRI
The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how…
- Trial name
- NCT07197918
- Testing
- portable MRI scanner
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.