Clinical trials: Central Nervous System Lesion
Postdural Puncture Headache, Sphenopalatine Ganglion Block
Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714
The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the…
- Trial name
- NCT03966547
- Testing
- Ganglion sphenopalatine block with local anesthetic administered on study GSPB-2018
- Where
- 2 sites in Denmark
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Stroke, Motor Cortex; Lesion
Imaging Laterality in Chronic Stroke Patients
In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex (PMC).
- Trial name
- NCT03584425
- Testing
- Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Patient With Atrial Fibrillation or High Stroke Risk
Continuous EKG Monitoring Using S-Patch Ex : Prospective Observational Study (S-patch Registry)
Atrial fibrillation (AF) is associated with increased mortality and morbidity, and is a dominant, yet preventable, cause of cardioembolic stroke, which has more severe outcomes than other ischaemic stroke causes if left…
- Trial name
- NCT05119725
- Testing
- continous 3 day EKG monitoring with S-Patch Cardio
- Where
- South Korea
- Volunteers
- 2,450 people
- Sponsor
- Yonsei University
Trauma, Brain, Mass Lesion
Assess the Clinical Effectiveness in AI Prioritising CT Heads
Non-Contrast Computed Tomography (NCCT) of the head is the most common imaging method used to assess patients attending the Emergency Department (ED) with a wide range of significant neurological presentations including trauma…
- Conditions
- Trauma, Brain, Mass Lesion, Skull Fractures, Hemorrhage, Intracranial
- Trial name
- ACCEPT (NCT06027411)
- Testing
- qER (qER EU 2.0)
- Where
- 4 sites in United Kingdom
- Volunteers
- 16,800 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Carotid Artery Stenosis
Impact of Aspiration Thrombectomy During Carotid Stenting
The purpose of this study is to determine whether aspiration thrombectomy following carotid stent deployment will reduce the number of procedure related signals as identified by diffusion weighted MRI of the brain.
- Trial name
- NCT01550835
- Testing
- Emboshield NAV6® embolic protection system (Abbott Vascular, Santa Clara, CA)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Fogarty Clinical Research Inc.
Spinal Cord Neoplasm
FDG PET-MRI for the Diagnosis of Spinal Cord Lesions
To compare the results and understand the possible benefits from FDG-PET/MRI during different scanning time points after FDG, a type of contrast drug, is given.
- Trial name
- NCT04219969
- Testing
- Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Ischemic Stroke
Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke
The purpose of this study is to identify a safe and effective bolus dose of intra-arterial/intra-thrombus alfimeprase in acute ischemic stroke (AIS) 3 to 9 hours from symptom onset.
- Trial name
- NCT00499902
- Testing
- alfimeprase
- Where
- 22 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- ARCA Biopharma, Inc.
Lung Carcinoma Metastatic to the Brain
MRI Perfusion on T1 and T2 Brain Lesion(s)
This study therefore aims to assess current treatment recommended by scientific societies [ 6-13 ] , brain MRI with injection of contrast for the diagnosis and monitoring of brain metastases .
- Trial name
- METAPERF (NCT02250755)
- Testing
- MRI T1 T2 sequences
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Amblyopia
Patch-free Occlusion Therapy
The purpose of the study is to determine whether a patch-free occlusion therapy leads to better visual outcomes in young children with amblyopia than standard-of-care occlusion therapy with an adhesive patch and whether this is…
- Trial name
- NCT05440448
- Testing
- Patch-free occlusion therapy, Adhesive patch
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Retina Foundation of the Southwest
Migraine Disorders, Brain
Audition After a Lesion and in Migraine. (AuditionPostLesion)
The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions.
- Trial name
- NCT02791997
- Testing
- Neuropsychological tests, Neurophysiological tests
- Where
- 2 sites in France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cerebrovascular Disorders
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
The purpose of the study is to test the hypothesis of slowing the progression of White Matter Lesions (WML) by lowering blood pressure (BP) in patients with cognitive complaints and a moderate to high grade of WML on brain MRI.
- Trial name
- LEOPOLD (NCT02472028)
- Testing
- blood pressure lowering algorithm, usual strategy
- Where
- 2 sites in France
- Volunteers
- 820 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vascular; Lesion, Central Nervous System, Brain Tumor
Intraoperative Fluorescence With Augmented Reality
This is a study looking at a new way to evaluate vascular problems or tumors in brain surgery patients using a standard \& approved intravenous dye and augmented reality.
- Conditions
- Vascular; Lesion, Central Nervous System, Brain Tumor, Cerebral Aneurysm, Cerebral AVM
- Trial name
- NCT03888014
- Testing
- GLOW800, indocyanine green (ICG)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cedars-Sinai Medical Center
Brain and Central Nervous System Tumors, Metastatic Cancer
Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders
RATIONALE: Learning about the side effects of stereotactic radiosurgery in patients with brain tumors or other brain disorders may help doctors plan treatment and help patients live more comfortably.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Radiation Toxicity
- Trial name
- NCT00255671
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Case Comprehensive Cancer Center
Central Nervous System Disease, Cerebrovascular Accident
Influence of Area of Brain Damage on Brain Reorganization After Chronic Stroke
This study will examine how the brain rewires itself to make up for the lack of movement many people with stroke experience. It will try to determine if the rewiring differs depending on the location of the stroke and the amount…
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Stroke
- Trial name
- NCT00474292
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Glioma, Brain Neoplasms
Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy
The primary objective is to evaluate and quantify the reproducibility of functional magnetic resonance imaging (fMRI) maps of the eloquent brain areas corresponding to specific neurological functions based on activation maps…
- Trial name
- NCT00214175
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Thoracic Cancer, Spine Cancer
Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine
Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than…
- Conditions
- Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease
- Trial name
- NCT04227717
- Testing
- MRI with custom MRI spine coil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Post-Dural Puncture Headache, Chronic Headache
Long Term Outcomes After Accidental Dural Puncture ADP Study
Post Dural Puncture Headache (PDPH) causes significant short-term disability, prevents mobilisation, affects childcare activities and results in prolonged hospital stay.
- Conditions
- Post-Dural Puncture Headache, Chronic Headache, Chronic Low Back Pain
- Trial name
- NCT03080779
- Where
- 3 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- University Hospitals, Leicester
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimer's Disease
Exelon Patch and Combination With Memantine Comparative Trial
The primary objective is to compare the tolerability between rivastigmine patch monotherapy and combination therapy with memantine in patients with Alzheimer's disease (AD).
- Trial name
- EXPECT (NCT01025466)
- Testing
- Rivastigmine transdermal patch (Exelon patch), memantine, Rivastigmine transdermal patch
- Where
- 26 sites in South Korea
- Volunteers
- 206 people
- Sponsor
- Inha University Hospital