Clinical trials: Central Nervous System Lesion, active
Brain Tumor
MRI-Guided Focused Ultrasound Feasibility Study for Brain Tumors
The purpose of this study is to evaluate the safety of MRI-guided focused ultrasound thermal ablation of brain tumors performed through intact human skull using the ExAblate transcranial system.
- Trial name
- NCT00147056
- Testing
- ExAblate transcranial system
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- InSightec
Hypothalamic Obesity, Hypothalamic Tumor
Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
Hypothalamic obesity (HO) refers to the substantial weight gain that often complicates hypothalamic brain tumors. Children with this treatment-recalcitrant form of obesity have excess rates of metabolic sequelae compared to…
- Conditions
- Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
- Trial name
- NCT06299891
- Testing
- Phentermine / Topiramate Extended Release Oral Capsule [Qsymia]
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Seattle Children's Hospital
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Giant Cell Arteritis
Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell Arteritis
Ultrasound evaluation of the temporal and axillary arteries is currently well recognized in the field of giant cell arteritis (GCA), a disease primarily affecting medium- and large-caliber vessels.
- Trial name
- ALERT (NCT06894602)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Subcortical Lesions, Stroke
Neuroplastic Changes Due to an Exercise Intervention That Aid in Lower Limb Recovery After Subcortical Stroke
This study aims to develop imaging-based biomarkers to assess which chronic stroke participant with lower extremity disability may respond or resist high intensity interval training (HIIT).
- Trial name
- NCT07663292
- Testing
- HIIT intervention
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Emory University
Splenomegaly, Splenectomy
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease
The goal of this clinical trial is to optimise and facilitate screening for Acid SphingoMyelinase Deficiency (ASMD) disease, by evaluating acid sphingomyelinase activity and, where appropriate, LysoSM levels in a cohort of 200…
- Conditions
- Splenomegaly, Splenectomy, Thrombopenia, Interstitial Lung Disease (ILD)
- Trial name
- Niemann-PID (NCT06869499)
- Testing
- Blood sampling for dosage
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Wladimir MAUHIN, Dr
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disorders, Brain Lesion
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective…
- Conditions
- Cerebrovascular Disorders, Brain Lesion, Degenerative Disease, Developmental Disability
- Trial name
- CORAC2 (NCT03586258)
- Testing
- Neuropsychological testing, Brain Imaging, Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Brain Injury, Neuropsychological Deficits
Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty
Cranioplasty is the main reconstructive neurosurgical procedure, performed in approximately 80% of patients who have previously undergone demolitive surgeries in an emergency setting, particularly in the case of decompressive…
- Conditions
- Brain Injury, Neuropsychological Deficits, Cranioplasty, Cognitive Deficit Following Brain Lesions
- Trial name
- NeC (NCT06895109)
- Testing
- improvement of cognitive functions and psychological aspects
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Amblyopia
Psilocybin for Amblyopia - Targeting Critical Periods in Humans
The purpose of this study is to evaluate whether ingestion of a drug called psilocybin can increase the effectiveness of amblyopia therapy in adults with amblyopia.
- Trial name
- PATCH (NCT07920081)
- Testing
- Amblyopia Therapy, 1 mg Psilocybin, 5 mg Psilocybin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Cystic Tumors of the Sellar/Parasellar Region
90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors
There is no consensus in the literature on the best way to treat cystic lesions of the pituitary area. Patients who are symptomatic from these tumours are rare.
- Trial name
- NCT02081768
- Testing
- 90yttrium colloid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- David Clarke
Brain Metastases, Radiotherapy Side Effect
Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods.
The study design concerns all patients diagnosed witha singular brain metastasis who underwent stereotactic radiosurgery/radiotherapy between January 2010 and December 2022
- Trial name
- STEREOMIC (NCT06869460)
- Testing
- Stereotactic Body Radiotherapy/Radiosurgery
- Where
- 4 sites in Italy
- Volunteers
- 372 people
- Sponsor
- Gemelli Molise Hospital
Amblyopia, Amblyopia Unilateral
Valproate for the Treatment of Residual Amblyopia
The goal of this clinical trial is to determine the efficacy of valproate as an adjunct therapy to treat amblyopia beyond the critical period in children aged 8-17 years who have amblyopia of ≥3 lines of interocular…
- Conditions
- Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
- Trial name
- VARA (NCT07226141)
- Testing
- Valproate, Patch
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Boston Children's Hospital
Drug-Resistant Epilepsy
Clinical Trial of SEEG for Drug-resistant Epilepsy
This trial evaluates the safety and efficacy of SEEG recording and functional mapping for patients with drug-resistant epilepsy.
- Trial name
- SEEG-DRE (NCT07923058)
- Testing
- SEEG RF-TC
- Where
- 17 sites in China
- Volunteers
- 99 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Brain Metastases, Brain Lesion
Preop fSRS for Resectable Brain Metastases
The purpose of the study is to determine whether treatment with pre-operative hypofractionated stereotactic radiosurgery followed by surgery will improve time to local failure (TTLF) compared to the current standard of care.
- Trial name
- NCT05267587
- Testing
- Hypofractionated Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Stroke, Acute, Traumatic Brain Injury
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage.
- Trial name
- Navomuss (NCT06718608)
- Testing
- imaging
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Brain Tumors
ALA-induced PpIX Fluorescence During Brain Tumor Resection
Removing a tumor from a patients brain is hard to do because, very often, brain tumors do not have boundaries that are easy for the patients surgeon to find.
- Trial name
- NCT02191488
- Testing
- 5-aminolevulinic acid
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- David W. Roberts
Glioma, Glioblastoma
Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system…
- Conditions
- Glioma, Glioblastoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT04047264
- Testing
- Microdialysis, Magnetic Resonance Imaging, Computed Tomography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital