Clinical trials: Central Nervous System Metastases
Secondary Hypothyroidism, Hypopituitarism
Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation
The purpose of this study is to determine whether a body weight adjusted dose of thyroxin is superior to treatment guided by laboratory results of thyroxin hormones in patients with central hypothyroidism.
- Conditions
- Secondary Hypothyroidism, Hypopituitarism, Hyperlipidemias
- Trial name
- NCT00360074
- Testing
- Thyroxin, Triiodothyronine
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University Hospital Freiburg
Stroke
Telestroke for Comprehensive Stroke Care in Acute Stroke Ready Hospitals
TELEstroke for Comprehensive Stroke Care in Acute Stroke Ready HospiTals (TELECAST) is a prospective single-center study evaluating guideline-based acute ischemic stroke care at an Acute Stroke Ready Hospital (ASRH) pre- and…
- Trial name
- TELECAST (NCT03672890)
- Testing
- Telestroke
- Where
- 5 sites in United States
- Volunteers
- 551 people
- Sponsor
- University of Minnesota
Breast Cancer, Brain Metastases
A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases
This is a multi-center, open-label, two-cohort study. The purpose of this study is to evaluate the safety, tolerability and efficacy of SHR-A1811 in the treatment of HER2-positive breast cancer with brain and leptomeningeal…
- Conditions
- Breast Cancer, Brain Metastases, Leptomeningeal Metastasis
- Trial name
- NCT07177950
- Testing
- SHR-A1811, radiotherapy
- Volunteers
- 51 people
- Sponsor
- Peking University Cancer Hospital & Institute
Brain Metastases
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy.
- Trial name
- NCT05045950
- Testing
- Memantine -Twice Daily or Extended Release, WBRT utilizing the PRDR technique
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medical College of Wisconsin
Medication Overuse Headache
Is Detoxification Needed in Medication-overuse Headache?
Medication-overuse headache (MOH) is a disabling condition, yet treatable. According to European guidelines and based on evidence, multidisciplinary detoxification is the first choice of treatment for MOH.
- Trial name
- DEFINE3 (NCT02993289)
- Testing
- Different well-known treatments
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer
HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease
The goal of this phase II clinical trial] is to analyze the efficacy of patritumab deruxtecan (HER3-DXd) in patients with metastatic breast cancer (MBC) or advanced non-small cell lung cancer (aNSCLC) with active brain metastases…
- Conditions
- Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer, Solid Tumor, Adult
- Trial name
- TUXEDO-3 (NCT05865990)
- Testing
- Patritumab deruxtecan
- Where
- 8 sites in Austria, Spain
- Volunteers
- 63 people
- Sponsor
- MedSIR
Metastatic Brain Cancer
A Feasibility Study of Image Guided Noninvasive Single Fraction Stereotactic Radiosurgery for the Treatment of Brain Metastases
Stereotactic radiosurgery (SRS) is a way to accurately treat brain tumors. SRS involves the use of a special head frame to keep the head from moving during treatment. The head frame makes very accurate treatment possible.
- Trial name
- NCT00610285
- Testing
- Fabrication of thermoplastic face (The Orfit thermoplastic face mask system is routinely used for the treatment of brain and head)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spinal Cord Injuries
The Use of Standing Powered Wheelchairs in Spinal Cord Injury
The purpose of this study was to explore the experiences of standing powered wheelchair users with spinal cord injury.
- Trial name
- NCT06145789
- Testing
- standing powered wheelchair evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Acute Ischemic Stroke
Efficacy and Safety of Indobufen, Aspirin, Cilostazol and Clopidogrel in the Treatment of Ischemic Stroke
Through a single-center retrospective cohort study of acute ischemic stroke (AIS) patients receiving secondary prevention with indobufen, clopidogrel, cilostazol, or aspirin as monotherapy or dual therapy, we aim to compare the…
- Trial name
- NCT07604298
- Testing
- indubufen, aspirin, clopidogrel, cilostazol
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Post-Concussion Syndrome, Post-Traumatic Headache
Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
The purpose of this study is to compare a 4-week, moderately intensive, lab and home-based aerobic exercise program versus exercise plus cognitive training.
- Conditions
- Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury
- Trial name
- NCT03674398
- Testing
- Exercise+CT, Exercise only
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
CNS Lymphoma, Primary Central Nervous System Lymphoma
Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma
This is a single arm open-label multicenter phase I/II investigation of combination lenalidomide/Tafasitamab in patients with relapsed central nervous system (CNS) lymphoma.
- Conditions
- CNS Lymphoma, Primary Central Nervous System Lymphoma, Secondary Central Nervous System Lymphoma
- Trial name
- NCT05351593
- Testing
- Tafasitamab, Lenalidomide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- James Rubenstein
Cervicogenic Headache
Additional Effects of Sternocleidomastoid Release With SNAGS in the Management of Cervicogenic Headache
Cervicogenic headache is a common type of headache in adults which causes disability and difficulty in everyday activities. According to the latest International Headache Society model, cervicogenic headache (CGH) is a secondary…
- Trial name
- NCT06534606
- Testing
- Electrotherapy and physical agents, Headache SNAGs, Sternocleidomastoid Release
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Intracerebral Haemorrhage
Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage
BEAT ICH will be a pragmatic, randomised, placebo-controlled, blinded, superiority clinical trial aiming to recruit 5676 patients aged ≥18 years who survive ICH and assign them 1:1 to starting antiplatelet monotherapy (Aspirin 75…
- Trial name
- BEAT-ICH (NCT07243704)
- Testing
- Aspirin 75 mg daily
- Where
- 33 sites in India
- Volunteers
- 5,676 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant
This randomized phase I trial studies the side effects of vaccine therapy in preventing cytomegalovirus (CMV) infection in patients with hematological malignancies undergoing donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01588015
- Testing
- tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- City of Hope Medical Center
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer
This clinical trial studies the side effects and best dose of giving fludarabine and total-body irradiation (TBI) together followed by a donor stem cell transplant and cyclosporine and mycophenolate mofetil in treating human…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00112593
- Testing
- fludarabine phosphate, total-body irradiation, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Fred Hutchinson Cancer Center
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Neoplasm in the Spine
SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine
This phase I pilot trial studies the side effects of stereotactic radiosurgery and nivolumab in treating patients with newly diagnosed melanoma that has spread to the brain or spine.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Neoplasm in the Spine, Stage IV Skin Melanoma
- Trial name
- NCT02716948
- Testing
- Laboratory Biomarker Analysis, Nivolumab, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Stroke, Intracerebral Haemorrhage
Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors.
- Conditions
- Stroke, Intracerebral Haemorrhage, Ischemic Stroke, TIA (Transient Ischemic Attack)
- Trial name
- NCT07414732
- Testing
- Savvy Medication Adherence Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Glioma, Brain Neoplasms
Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases
This is a randomized pilot study to investigate the ability of a phosphodiesterase-V inhibitor (vardenafil) to increase the concentration of systemically delivered chemotherapy, carboplatin, in patients with recurrent malignant…
- Conditions
- Glioma, Brain Neoplasms, Brain Metastasis
- Trial name
- LevitraCarbo (NCT02279992)
- Testing
- Vardenafil, Carboplatin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cedars-Sinai Medical Center
Brain and Central Nervous System Tumors, Lymphoma
Melphalan With BBBD in Treating Patients With Brain Malignancies
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Metastatic Cancer
- Trial name
- NCT00253721
- Testing
- Melphalan
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- OHSU Knight Cancer Institute
Brain Metastases, Adult
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery
Brain metastases (BM) represents a devastating clinical reality, carrying an estimated survival time of less than one year. Number of reasons, including complicated tumor biology and difficulties in modeling metastatic cancer in…
- Trial name
- NCT04785521
- Testing
- Stereotactic radiosurgery, Blood samples
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele