Clinical trials: Central Nervous System Sensitization
Subacromial Impingement Syndrome, Central Nervous System Sensitization
Muscle Function, Central Nervous System Sensitization, and Pain Profiling in Patients With Subacromial Pain (SAP-CNSS).
In this case-control study, the investigators compare shoulder muscle function, pain, and central nervous system sensitization in patients with Subacromial Pain (SAP) to that in healthy controls.
- Trial name
- NCT03326466
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Insomnia, Fibromyalgia
Sleep and Pain Interventions in Fibromyalgia
This is a single-center, randomized controlled trial study design. Enrolled participants had comorbid fibromyalgia and chronic insomnia.
- Trial name
- SPIN (NCT02001077)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Cognitive Behavioral Therapy for Pain (CBT-P)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University of Florida
Low Back Pain, Chronic Low Back Pain
Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central Sensitization
The goal of this randomized controlled study is to evaluate the effectiveness of pain neuroscience education (PNE) combined with neuromuscular exercises (NME) in individuals with chronic low back pain and central sensitization…
- Conditions
- Low Back Pain, Chronic Low Back Pain, Central Sensitization
- Trial name
- NCT07866690
- Testing
- Pain Neuroscience Education, Neuromuscular Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Izmir Katip Celebi University
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Neuropathic Pain
The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA).
- Trial name
- NCT05581836
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- The Catholic University of Korea
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Diabetic Adhesive Capsulitis, Frozen Shoulder
Pain Neuroscience Education and Graded Motor Imagery Combined With Conventional Physiotherapy on Diabetic Adhesive Capsulitis
The purpose of this study is to determine the effects of Pain Neuroscience Education (PNE) and Graded Motor Imagery (GMI) combined with conventional physiotherapy on pain, kinesiophobia, central sensitization, functional…
- Conditions
- Diabetic Adhesive Capsulitis, Frozen Shoulder, Type II Diabetes Mellitus
- Trial name
- NCT07763366
- Testing
- Pain Neuroscience Education (PNE), Graded Motor Imagery (GMI), Conventional Physiotherapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Complex Regional Pain Syndrome (CRPS)
Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome
Transcranial direct current stimulation (tDCS) is a non-invasive therapy increasingly used in facilities treating patients with chronic pain.
- Trial name
- ALGOSTIM (NCT07361692)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Polyclinique de l'Europe
Migraine, Migraine Disease
Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors.
- Conditions
- Migraine, Migraine Disease, Migraine Disorder, Migraine Disorders, Brain
- Trial name
- NCT06716489
- Testing
- Supervised Aerobic Exercise plus Pain Neuroscience Education, Physical Activity Recommendations
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Carpal Tunnel Syndrome
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in…
- Trial name
- NCT00929123
- Testing
- neural mobilization, healthy controls
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fibromyalgia, Sedentary Behavior
Sedentary Status and Multidimensional Outcomes in Fibromyalgia
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and functional limitations.
- Conditions
- Fibromyalgia, Sedentary Behavior, Kinesiophobia, Central Sensitisation
- Trial name
- NCT07358702
- Testing
- Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Izmir Democracy University
Fibromyalgia, Chronic Pain
Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)
The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity)…
- Conditions
- Fibromyalgia, Chronic Pain, Nociplastic Pain
- Trial name
- PEARL (NCT07677631)
- Where
- 5 sites in Italy
- Volunteers
- 425 people
- Sponsor
- University of Bari
Central Nervous System Sensitization
Correlation Between Central Sensitization Inventory and Posturographic Data
To investigate the use of balance as a screening tool for Central Sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain.
- Trial name
- NCT03058003
- Testing
- Posturography Evaluation, Central Sensitization Inventory
- Where
- 2 sites in United States, Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Caps Research Network
Osteoarthritis
Neuroscience Education on Osteoarthritis
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain.
- Trial name
- NCT02246088
- Testing
- MT + NE, MT + E
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- University of Valencia
Osteoarthritis, Knee
Transcutaneous Electrical Nerve Stimulation in Relation to Central Sensitization in Osteoarthritis of the Knee
Background Central sensitization has recently been documented in patients with knee osteoarthritis. So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing the pain…
- Trial name
- TENSSENS (NCT01390285)
- Testing
- Transcutaneous electric nerve stimulation
- Volunteers
- 98 people
- Sponsor
- Vrije Universiteit Brussel
Central Sensitisation, Chronic Musculoskeletal Disease
The Frequency of Central Sensitization in Patients With Chronic Musculoskeletal Pain
Central sensitization is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Conditions
- Central Sensitisation, Chronic Musculoskeletal Disease, Chronic Pain
- Trial name
- NCT04765280
- Testing
- Central sensitization inventory, Short form-36, Istanbul Low Back Pain Disability Index
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Marmara University
Behcet's Disease, Central Sensitisation
Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
There are few studies in the literature regarding increased frequency of neuropathic pain and sleep disturbance and decreased quality of life in Behçet's disease.
- Trial name
- NCT03531385
- Testing
- Central sensitisation, Neuropathic pain, Sleep disturbance
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital