Clinical trials: Central Pain Syndrome
Subacromial Pain Syndrome
Effects of Blood Flow Restriction Training in Rotator Cuff Related Shoulder Pain
Blood flow restriction training is widespread in sport performance areas, where it has proven to be beneficial in strength and hypertrophy development.
- Trial name
- NCT04834271
- Testing
- Side-lying external rotation exercise with a dumbbell, Side-lying external rotation exercise with a dumbbell with 40% arterial occlusion pressure blood flow restriction, Side-lying external rotation exercise with a dumbbell with 80% arterial occlusion pressure blood flow restriction
- Where
- Spain
- Sponsor
- University of Alcala
Chest Pain, Acute Coronary Syndrome
The FOVUS-ER Study: Focused Vascular Ultrasound to Risk Stratify Patients With Chest Pain in the ER
Broad Goal: To demonstrate that focused vascular ultrasound (FOVUS) can accurately risk stratify patients with chest pain in the emergency department (ED).
- Conditions
- Chest Pain, Acute Coronary Syndrome, Carotid Artery Plaque
- Trial name
- FOVUS-ER (NCT02947360)
- Testing
- Focused vascular ultrasound of the carotid arteries
- Where
- Canada
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Queen's University
Behcet's Disease, Central Sensitisation
Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
There are few studies in the literature regarding increased frequency of neuropathic pain and sleep disturbance and decreased quality of life in Behçet's disease.
- Trial name
- NCT03531385
- Testing
- Central sensitisation, Neuropathic pain, Sleep disturbance
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Marfan Syndrome
Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease
Primary outcome is to compare the frequency and clinical features of spinal symptoms between Marfan patients with dural ectasia (cases) and those without (controls). 1. / Frequency of orthostatic headaches 2.
- Trial name
- MARFANLOMB (NCT05123339)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post Concussive Headache, Post Concussive Syndrome
Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Concussion is defined as any temporary disturbance in brain function following a blow to the head. It may not involve a loss of consciousness and usually results in a post concussive headache (PCH) immediately after the injury.
- Trial name
- NCT00237705
- Testing
- metoclopramide
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Pain, Intractable, Central Pain Syndrome
Long-term Effect of Motor Cortex Stimulation in Patients Suffering From Chronic Neuropathic Pain
In order to create insights in the effects of Motor cortex stimulation (MCS) on intractable pain, an open observational study was started in 2003. The aim of this research is to: 1.
- Conditions
- Pain, Intractable, Central Pain Syndrome, Facial Pain
- Trial name
- MCSNL (NCT03189823)
- Testing
- Specify, model 3998, Medtronic Inc., Minneapolis, MN, USA
- Volunteers
- 17 people
- Sponsor
- Radboud University Medical Center
Pelvic Pain, Vulvodynia
Psychosocial Factors and Central Sensitization in Chronic Pelvic Pain
The purpose of this study is to determine if the psychosocial factors in women with chronic pelvic pain are predisposing, precipitant or maintenance factors, and relate these factors with central sensitization and dysfunctional…
- Conditions
- Pelvic Pain, Vulvodynia, Pudendal Neuropathy
- Trial name
- NCT02856334
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pain, Intractable
OPTIONS Spinal Cord Stimulation Programming Parameters
The purpose of this study is to evaluate programming options in spinal cord stimulation for the management of chronic, intractable pain of the trunk and limbs.
- Trial name
- NCT02503787
- Testing
- Spinal Cord Stimulation (SCS)
- Where
- 11 sites in United States
- Volunteers
- 64 people
- Sponsor
- MedtronicNeuro
Pain
Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film
The primary aim of this study is to determine if chronic pain subjects on around-the-clock opioids who are receiving 100 to 220 mg oral morphine sulfate equivalent (MSE) can be safely transitioned on to buprenorphine…
- Trial name
- NCT01871285
- Testing
- Buprenorphine, Oxycodone, Morphine sulfate
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- BioDelivery Sciences International
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Shoulder Pain, Shoulder Impingement
Efficacy Of Platelet Rich Plasma In The Treatment Of Hemiplegıc Shoulder Pain
In this study assessing whether platelet rich plasma injections(PRP) are effective in the management hemiplegic shoulder pain, 55 patients with hemiplegic shoulder pain was recruited to this randomized controlled study.
- Conditions
- Shoulder Pain, Shoulder Impingement, Hemiplegia, Infantile, Shoulder Subluxation
- Trial name
- NCT03931824
- Testing
- PRP, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ege University
Shoulder Pain, Shoulder Impingement Syndrome
Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury
Rotator cuff disease (i.e., rotator cuff tendinopathy or tear) is a common cause of shoulder pain in persons with chronic spinal cord injury (SCI).
- Conditions
- Shoulder Pain, Shoulder Impingement Syndrome, Rotator Cuff Impingement Syndrome, Rotator Cuff Tendinitis
- Trial name
- NCT03167138
- Testing
- Autologous micro-fragmented adipose tissue, Lipogems system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Temporomandibular Disorder, Temporomandibular Joint Disorders
Effect of Exercises on Convergence Insufficiency in Individuals With Temporomandibular Disorders
Temporomandibular Disorder is a disorder that involves the muscles of mastication, the temporomandibular joint (TMJ), and associated structures.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome, Convergence Insufficiency
- Trial name
- NCT05761106
- Testing
- Oculomotor Therapy, Therapy for Temporomandibular Disorder
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Nove de Julho
Paraplegia, Spinal Cord Injuries
Natural History of Shoulder Pathology in Manual Wheelchair Users
Over 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level…
- Conditions
- Paraplegia, Spinal Cord Injuries, Shoulder Pain, Tendinopathy
- Trial name
- NHSSI (NCT02600910)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Migraine, Pain, Shoulder
Effects of MTRPs Therapy in Migraine.
Case series, repeated-measures design, pilot study. Adult, female, migraine patients underwent seven Ischemic Compression Myofascial Trigger Points (IC-MTrPs) therapy sessions.
- Conditions
- Migraine, Pain, Shoulder, Trapezius Muscle Strain Left, Trapezius Muscle Strain Right
- Trial name
- MTRPs (NCT05646160)
- Testing
- Ischemic Compression of Myofascial Trigger Points (IC-MTRPs)
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Knee Osteoarthritis, Knee Pain Chronic
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
- Trial name
- NCT06105788
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Postural; Defect, Tension-Type Headache
Fascial Distortion Model in Tension Type Headache
Tension-type headache is a headache that starts from the cervical and suboccipital regions, spreads from the back of the head to the parietal, frontal and temporal regions, and is felt in the form of compression, pressure and…
- Conditions
- Postural; Defect, Tension-Type Headache, Pain, Neck, Craniovertebral; Syndrome
- Trial name
- NCT05964517
- Testing
- Fascial Distortion Model
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- University of Gaziantep
Complex Regional Pain Syndromes, Fibromyalgia
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
Motor neglect describes a loss of function without a loss of strength, reflexes or sensation. Motor neglect has been described in patients with traumatic brain injury, stroke and chronic pain conditions, e.g.
- Conditions
- Complex Regional Pain Syndromes, Fibromyalgia, Stroke, Traumatic Brain Injury
- Trial name
- VERMONT (NCT03887962)
- Testing
- Virtual Environment Biofeedback, Treadmill walking with no Virtual Environment Biofeedback
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust