Clinical trials: Central Pain Syndrome
Angina Pectoris, Unstable Angina
Pilot Study of Hemoglobin Based Oxygen Therapeutics in Elective Coronary Revascularization
The purpose of this study is to assess the safety and feasibility of a novel oxygen carrying solution, HBOC-201, in the setting of PCI for Acute Coronary Syndromes from randomization til hospital discharge.
- Conditions
- Angina Pectoris, Unstable Angina, Myocardial Infarction
- Trial name
- NCT00317512
- Testing
- Percutaneous Coronary Revascularization, Hemoglobin-Based Oxygen Carrier-201 (HBOC-201), Voluven
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 45 people
- Sponsor
- Biopure Corporation
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Pain Syndrome, Mastectomy
Postmastectomy Pain Syndrome in an Indian Cancer Hospital
Breast cancer is the most common cancer in women in India and accounts for 27% of all cancers in women. Incidence rises in early thirties, peaks at 50-64 years. Approximately 48% are below 50 years of age.
- Conditions
- Pain Syndrome, Mastectomy, Quality of Life
- Trial name
- NCT03067922
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tata Memorial Centre
Pain, Spinal Cord Injury
Deep rTMS in Central Neuropathic Pain Syndromes
Pain affects up to 30% of the general population. In particular, neuropathic pain (NeP) is caused by lesion or desease affecting peripheral or central somatosensory pathways and affects 7% of the adult population.
- Conditions
- Pain, Spinal Cord Injury, Post Stroke Pain
- Trial name
- DRTMS (NCT01932905)
- Testing
- deep rTMS
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Interstitial Cystitis
A Pilot Clinical Investigation of the Efficacy and Safety of Uracyst® Versus Placebo in Patients With Interstitial Cystitis/Painful Bladder Syndrome.
This is a pilot clinical investigation. Patients who meet the eligibility criteria and provide signed informed consent will be randomized to receive either an active product (Uracyst®) or placebo intravesically via a bladder…
- Trial name
- NCT00527917
- Testing
- Uracyst
- Where
- 13 sites in Canada
- Volunteers
- 65 people
- Sponsor
- Watson Pharmaceuticals
Migraine Disorders
Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE
The primary objective of this study is to evaluate the safety and efficacy of occipital nerve stimulation (ONS) using the Boston Scientific Corporation (BSC) Precision™ System in the management of intractable chronic migraine…
- Trial name
- OPTIMISE (NCT01775735)
- Testing
- Occipital nerve stimulator
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boston Scientific Corporation
Postpoliomyelitis Syndrome
A Randomized, Double Blind, Placebo Controlled Trial L-carnitine and Piracetam in the Treatment of Weakness, Muscle Fatigue and Muscle Pain in the Postpoliomyelitis Syndrome
This protocol aims to assess of L-carnitine and piracetam to relieve weakness, muscle fatigue and muscle pain in patients with Postpoliomyelitis Syndrome.
- Trial name
- NCT01549847
- Testing
- L-carnitine and piracetam
- Where
- Brazil
- Sponsor
- Biolab Sanus Farmaceutica
Lung Neoplasms, Respiratory Failure
Clearance Of Mucus In Stents (COMIS)
The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.
- Conditions
- Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes
- Trial name
- NCT01370278
- Testing
- Normal Saline, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Subacromial Pain Syndrome, Central Sensitisation
The Segmental Distribution of Hypersensitivity in Patients With Chronic Subacromial Pain Syndrome
This study aimed to determine the distribution of pain sensitivity according to body segments in patients with central sensitization associated with chronic subacromial pain syndrome (SPS).This cross-sectional study included…
- Trial name
- NCT06139120
- Testing
- Assessment of hypersensitivity
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Congenital Heart Defect, Chronic Pain
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care
Over the past four decades, it has become clear that childhood physical activity carries with it a myriad of beneficial effects.
- Conditions
- Congenital Heart Defect, Chronic Pain, Concussion Post Syndrome, Cerebral Palsy
- Trial name
- NCT04106154
- Testing
- Kinesiology Support
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Children's Hospital of Eastern Ontario
Extubation Success, Craniofacial Pain Syndrome
The Predictive Value of Peak Cough Flow for Endotracheal Extubation of Patients After Craniotomy
In severe cases after craniotomy, tracheal intubation is often required, and the removal of tracheal intubation presents certain risks and challenges.
- Conditions
- Extubation Success, Craniofacial Pain Syndrome, Cough Peak Flow, Endotracheal Tube
- Trial name
- PCFET (NCT04000997)
- Where
- China
- Volunteers
- 785 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain, Postoperative Pain
Risk of Failed Epidural in Patients With and Without Chronic Pain and Opioid Use
Patients with chronic pain syndrome (CPS) may develop central sensitization wich may lead to increased pain intensity and lower pain threshold sometimes to the extend of hyperalgesia and allodynia.
- Conditions
- Chronic Pain, Postoperative Pain, Central Sensitisation
- Trial name
- NCT05662566
- Testing
- Epidural replacement
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Eske Kvanner Aasvang
Carpal Tunnel Syndrome
Effects of Cerebral & Peripheral Electrical Stimulation on Pain and Function in CTS
This is a randomized, double-blind, multi-center, factorial clinical trial to study the effectiveness of cerebral and peripheral electrical stimulation on pain and functional limitations associated with carpal tunnel syndrome…
- Trial name
- DCS-ENS-CTS (NCT04092088)
- Testing
- tDCS-r, TENS-r, tDCS-s
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Myofascial Pain Syndromes
Myofascial Pain:Acupuncture Versus Trigger Point Injection Combined With Dipyrone and Cyclobenzaprine
CONTEXT AND OBJECTIVE: Myofascial syndrome is the most frequent condition of chronic pain. The objective of the present study was to compare the analgesic action of acupuncture and trigger point injection combined with…
- Trial name
- ACP (NCT00635037)
- Testing
- bupivacaine and acupuncture
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cyclic Vomiting Syndrome
Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes of stereotypical vomiting.
- Trial name
- NCT04645953
- Testing
- 3mg AZ-010, 1mg AZ010
- Where
- 18 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Patellofemoral Pain Syndrome
Central Neuromuscular Dysfunction in Patellofemoral Pain
Patellofemoral joint problems constitute a significant portion of knee pain and injuries. Patellofemoral pain, which is among these problems, is a common musculoskeletal disorder with a poor long-term prognosis in the community.
- Trial name
- NCT05561153
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fibromyalgia, Myofascial Pain Syndrome
Shock-Waves to Treat Fibromyalgia Pain
Fibromyalgia pain syndrome is a common debilitating condition which associates mainly generalised pain, emotional distress and cognitive symptoms. The etiology is unknown, and no specific treatment exists so far.
- Conditions
- Fibromyalgia, Myofascial Pain Syndrome, MSK: Chronic Pain Syndromes (E.G. Fibromyalgia), Central Sensitization
- Trial name
- SWPW-FPS (NCT03088215)
- Testing
- shock-waves
- Volunteers
- 40 people
- Sponsor
- Dr Yves JACOT, MD
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Herniated Disc, Failed Back Surgery Syndrome
The Effect of Central Sensitization in Radicular Pain in Patients With Failed Low Back Surgery Syndrome
The Effect of Central Sensitization in Radicular Pain in Patients with Failed Low Back Surgery Syndrome on Treatment Success of Ultrasound-Guided Caudal Epidural Steroid Injection
- Trial name
- NCT06508918
- Testing
- Betametasona
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Marmara University