Clinical trials: Central Sleep Apnea
Obstructive Sleep Apnea Syndrome
Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
To study the effect of Xyrem (9 g), Xyrem (9 g) plus modafinil 200 mg administered the morning prior to Xyrem, positive control (zolpidem 10 mg), and placebo on the frequency and outcome of events of sleep-disordered breathing in…
- Trial name
- NCT00086281
- Testing
- Xyrem (X), Zolpidem (Z), Modafinil (M)
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Jazz Pharmaceuticals
Apnea, Sleep
Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study
The United States is currently experiencing an increase in the incidence and prevalence of obstructive sleep apnea (OSA). With prevalence in middle-aged adults of 2 to 4% of the population, untreated OSA has been implicated in…
- Trial name
- NCT02349893
- Testing
- RFA treatment
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Olympus Surgical Technologies Europe
Sleep-disordered Breathing
Sleep and Breathing in the General Population - Chemical Stimuli
Central sleep apnea (CSA) is a common condition and its treatment remains elusive. The focus of this proposal is to identify the role of the physiologic path involving cortical arousals in CSA by decreasing arousal frequency…
- Trial name
- NCT04720547
- Testing
- Zolpidem, No Treatment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Sleep Apnea, Obstructive, Sleep Apnea, Central
DreamKit Respiratory Effort Signal Validation
This study has been developed in order to demonstrate the validity of the DreamKit respiratory effort signal.
- Trial name
- NCT04926077
- Testing
- DreamKit
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Sleep Apnea, Stroke
Positional Therapy After Stroke
Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Unfortunately, there are few therapies that have been proven to improve stroke outcome.
- Trial name
- NCT01047709
- Testing
- Positional therapy including the use of a special pillow
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Congestive Heart Failure, Left Ventricular Systolic Dysfunction
Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry
Objective target of the registry is to investigate the prevalence of SDB as well as the clinical characteristics of patients with and without SDB as well as the predominant type of sdb.
- Trial name
- SchlaHF (NCT01500759)
- Where
- 199 sites in Australia, Germany
- Volunteers
- 6,876 people
- Sponsor
- ResMed
Heart Failure, Central Sleep Apnea
The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea
The purpose of this trial is to evaluate the long-term effects of Nocturnal Oxygen Therapy (NOXT) on the mortality and morbidity of patients with stable heart failure and a reduced ejection fraction (HFrEF), already receiving…
- Trial name
- NCT03745898
- Testing
- Oxygen, Room Air
- Where
- 26 sites in United States
- Volunteers
- 98 people
- Sponsor
- Brigham and Women's Hospital
Central Apnea, Heart Failure
Buspirone as a Potential Treatment for Recurrent Central Apnea
The purpose of this study is to determine whether buspirone compared to acetazolamide and to placebo will reduce the number and/or severity of breathing pauses during sleep that occur in some patients with Heart Failure.
- Trial name
- CSA treatment (NCT00746954)
- Testing
- Acetazolamide, Buspirone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Sleep Disordered Breathing
Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic…
- Trial name
- Serve-HF (NCT00733343)
- Testing
- Europe: AutoSet CS (USA: VPAP Adapt SV)
- Where
- 267 sites in Australia, Czechia and 9 more
- Volunteers
- 1,325 people
- Sponsor
- ResMed
Central Sleep Apnea
Post Approval Study of the remedē System
Prospective, single arm cohort study to evaluate the long-term safety, long-term effectiveness, and survival rate in subjects implanted with the remedē System.
- Trial name
- NCT03425188
- Where
- 17 sites in United States, Germany
- Volunteers
- 53 people
- Sponsor
- Respicardia, Inc.
Spinal Cord Injury, Sleep Disordered Breathing
Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury…
- Trial name
- REST-SCI (NCT02458469)
- Testing
- Buspirone, Trazodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis)
Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use
Prospective, randomized, blinded, cross-over study assessing the effectiveness of adaptive servo-ventilation (ASV) in treating patients who have obstructive sleep apnea (OSA) complicated by central sleep apnea (CSA) due to the…
- Conditions
- Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis), Chronic Opioid Use
- Trial name
- NCT01462084
- Testing
- Adaptive servo-ventilation (ASV), Bi-Level PAP
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- ResMed
Sleep Apnea, Age
Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly.
- Trial name
- NCT00732199
- Testing
- 1) hyperventilation via noninvasive positive pressure ventilation 2) multiple trials of episodic hypoxia
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sleep Apnea, Central, Sleep Apnea, Obstructive
Evaluation of ApneaLink Plus Scoring Capabilities
The purpose of this study is to investigate the following topics: Determine the accuracy of ApneaLink Plus in separating Apneas into Obstructive Apneas, Mixed Apneas and Central Apneas.
- Trial name
- NCT00823134
- Testing
- ApneaLink Plus
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- ResMed
Parkinson's Disease, Sleep Disordered Breathing
Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease
Patients with sleep disordered breathing (SDB), also called sleep apnea, experience nighttime disrupted sleep and, because they stop breathing for short periods during the night, do not get sufficient oxygen to their brains.
- Trial name
- TAP (NCT00492115)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Central, Sleep Disordered Breathing
Respicardia, Inc. Pivotal Trial of the remedē System
The primary purpose of this prospective, multicenter, randomized trial is to evaluate the safety and effectiveness of therapy delivered by the remedē® system in subjects with moderate to severe central sleep apnea and optimal…
- Conditions
- Sleep Apnea, Central, Sleep Disordered Breathing, Heart Failure
- Trial name
- NCT01816776
- Testing
- Treatment Group (transvenous stimulation of the phrenic nerve), Control Group (Optimal Medical Therapy)
- Where
- 30 sites in United States, Germany and 1 more
- Volunteers
- 151 people
- Sponsor
- Respicardia, Inc.
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Sleep Apnea Central, Cheyne-Stokes Respiration
Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
The purpose of this study is to demonstrate diagnostic agreement and determine the accuracy of the continuous positive airway pressure (CPAP) device compared to simultaneous, attended clinical polysomnography (PSG) in identifying…
- Conditions
- Sleep Apnea Central, Cheyne-Stokes Respiration, Obstructive Sleep Apnea
- Trial name
- NCT01175031
- Testing
- Manipulation of Positive Airway Pressure (PAP)
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Philips Respironics
Obstructive Sleep Apnea
CPAP vs AutoCPAP for Treatment of Obstructive Sleep Apnea (OSA) in the Postoperative Setting
The purpose of this study is to determine if an Autoadjusting CPAP machine is better than the regular CPAP machine in treatment of Obstructive Sleep Apnea in the postoperative setting.
- Trial name
- NCT00588848
- Testing
- Autoadjusting CPAP (VPAP Auto), CPAP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- MetroHealth Medical Center
Epilepsy, Sleep Apnea
Effects of Treating Obstructive Sleep Apnea in Epilepsy
The purpose of this trial is to work out design issues prior to conducting a definitive phase 3 trial to determine whether treating sleep-related breathing disorders in people with epilepsy results in improvement in seizure…
- Conditions
- Epilepsy, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- NCT00047463
- Testing
- continuous positive airway pressure (CPAP)
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University