Clinical trials: Central Sleep Apnea
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study
The purpose of study JZP110-405 is to determine whether solriamfetol is effective at improving cognitive function in participants with excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA) plus impaired…
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea, Impaired Cognitive Function
- Trial name
- SHARP (NCT04789174)
- Testing
- Solriamfetol
- Where
- 28 sites in United States, Canada and 4 more
- Volunteers
- 59 people
- Sponsor
- Axsome Therapeutics, Inc.
Obstructive Sleep Apnea, Stroke
Sleep Apnea Treatment After Stroke (SATS)
The purpose of this study is to determine if treating stroke patients who have obstructive sleep apnea with continuous positive airway pressure will improve symptoms caused by the stroke.
- Trial name
- NCT00282815
- Testing
- continuous positive airway pressure or CPAP
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Sleep Apnea Syndromes, Insomnia Disorder
Apnea and Insomnia Relief Study
The purpose of this study is to determine whether a behavioral sleep treatment improves functioning and sleep in Veterans with posttraumatic stress disorder (PTSD).
- Conditions
- Sleep Apnea Syndromes, Insomnia Disorder, Stress Disorders, Post-Traumatic
- Trial name
- AIR (NCT04007796)
- Testing
- Apnea and Insomnia Relief (AIR), Sleep Education (SE)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea, Obstructive, Stroke
Stroke and CPAP Outcome Study 2
Obstructive sleep apnea (OSA) is associated with impaired stroke recovery. Treatment with continuous positive airway pressure (CPAP) may prevent this but is limited by poor adherence.
- Conditions
- Sleep Apnea, Obstructive, Stroke, Patient Adherence
- Trial name
- SCOUTS2 (NCT02809430)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Obstructive Sleep Apnea, Hypercapnia
Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Patients with spinal cord injury (SCI) usually breathe without any mechanical assistance, but significant breathing problems occur often during sleep, either because the upper airway closes (obstructive sleep apnea; OSA), or…
- Conditions
- Obstructive Sleep Apnea, Hypercapnia, Spinal Cord Injury
- Trial name
- NCT01882257
- Testing
- BiPAP, BiPAP/AVAPS (Phillips Respironics)
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Michigan
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Obstructive Sleep Apnea
DeVilbiss AutoAdjust With SmartFlex Comparative Study
There will be equivalent therapeutic effectiveness between SmartFlex and standard modes when using the DeVilbiss AutoAdjust device.
- Trial name
- NCT01203956
- Testing
- SmartFlex, Standard
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- DeVilbiss Healthcare LLC
Spinal Cord Injury, Sleep-disordered Breathing
Treatment of Sleep-disordered Breathing in Patients With SCI
Sleep-disordered breathing (SDB) remains under-treated in individuals living with spinal cord injuries and disorders (SCI/D). The investigators' aim is to test a program that addresses challenges and barriers to positive airway…
- Conditions
- Spinal Cord Injury, Sleep-disordered Breathing, Spinal Cord Disease, Multiple Sclerosis
- Trial name
- NCT02830074
- Testing
- Best practices PAP + patient Education +ongoing Support and Training, Sleep Education
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Sleep Disordered Breathing
Role of Mirtazapine in Ameliorating Sleep Disordered Breathing
The purpose of this study is to look at the effect of using Mirtazapine to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury (SCI)…
- Trial name
- NCT04799782
- Testing
- Mirtazapine
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Parkinson's Disease, Sleep Disordered Breathing
Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease
Patients with sleep disordered breathing (SDB), also called sleep apnea, experience nighttime disrupted sleep and, because they stop breathing for short periods during the night, do not get sufficient oxygen to their brains.
- Trial name
- TAP (NCT00492115)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Obstructive Sleep Apnea in World Trade Center Responders
The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders.
- Trial name
- NCT01753999
- Testing
- Standard CPAP, CPAP - Flex
- Where
- 3 sites in United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Sleep Disordered Breathing, Cheyne Stokes Respiration
Chronic Evaluation of Respicardia Therapy
The purpose of this study is to determine the chronic safety and efficacy of phrenic nerve stimulation on central sleep apnea (CSA).
- Conditions
- Sleep Disordered Breathing, Cheyne Stokes Respiration, Periodic Breathing, Sleep Apnea
- Trial name
- NCT01124370
- Testing
- remedē (TM) system
- Where
- 13 sites in United States, Germany and 2 more
- Volunteers
- 57 people
- Sponsor
- Respicardia, Inc.
Heart Failure, Sleep Apnea Syndromes
Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients
Heart Failure affects 5-6 million Americans and there are about 550 thousand new cases of heart failure every year. There are approximately 3 million hospital admission for acute decompensated heart failure with hospital…
- Trial name
- ARIA-II (NCT00804349)
- Testing
- Autotitrating Positive Airway Pressure
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein Healthcare Network
Sleep Apnea, Stroke
Positional Therapy After Stroke
Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Unfortunately, there are few therapies that have been proven to improve stroke outcome.
- Trial name
- NCT01047709
- Testing
- Positional therapy including the use of a special pillow
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Migraine With Aura, Patent Foramen Ovale
Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP)
The purpose of the study is to compare the rate of comorbidities associated with migraine aura (MA) between persons who have a large circulatory right-to-left shunt (RLS) and those who do not have RLS.
- Trial name
- CAMP (NCT01257880)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Swedish Medical Center
Central Apnea, Heart Failure
Buspirone as a Potential Treatment for Recurrent Central Apnea
The purpose of this study is to determine whether buspirone compared to acetazolamide and to placebo will reduce the number and/or severity of breathing pauses during sleep that occur in some patients with Heart Failure.
- Trial name
- CSA treatment (NCT00746954)
- Testing
- Acetazolamide, Buspirone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
Sleep Disordered Breathing, Sleep Apnea, Central
Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device
This study is being undertaken to collect data from Respironics Inc's BiPAP Auto Servo Ventilation 3 (autoSV3) and compare with data from Respironics, Inc's BiPAP autoSV2, to confirm that the algorithms in the BiPAP autoSV3…
- Trial name
- AUTOSV3 (NCT00720213)
- Testing
- Respironics BiPAP autoSV2, Respironics BiPAP autoSV3
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Spinal Cord Injury, Sleep Disordered Breathing
Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury…
- Trial name
- REST-SCI (NCT02458469)
- Testing
- Buspirone, Trazodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stroke, Obstructive Sleep Apnea
Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
There are two purposes of this study. The first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life.
- Trial name
- BOSAST (NCT00952211)
- Testing
- CPAP, CPAP at sub-therapeutic pressure
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Obstructive, Sleep Apnea, Central
DreamKit Diagnostic Validation
This study has been developed in order to demonstrate diagnostic efficacy of the DreamKit device against polysomnography.
- Trial name
- NCT04671342
- Testing
- DreamKit
- Where
- 7 sites in United States
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global