Clinical trials: Central Spinal Cord Syndrome
Overactive Bladder
OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine.
- Trial name
- NCT01050114
- Testing
- onaBoNT-A, Oxybutynin ER
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Christopher Patrick Smith
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Spinal Cord Injury
Neural Adaptation After Tendon Transfer and Training in Tetraplegia
The number of people in the United States who have survived SCI is estimated to be approximately 273,000 persons. Around 50% of the injuries are to the cervical spine resulting in tetraplegia.
- Trial name
- NCT02768103
- Testing
- task-based training
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cord Compression
Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation After Cancer-Related Cord Compression
The purpose of this research study is to look at a combination treatment of radiation therapy and a drug called Abraxane to treat epidural spinal cord compression.
- Trial name
- NCT03655080
- Testing
- Radiation therapy, nab-Paclitaxel
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Metabolic Syndrome
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
Evaluate and compare the health benefits of an at home exercise program using functional electrical stimulation (FES) for lower extremity exercise with diet versus a diet alone group in adults with spinal cord injury.
- Conditions
- Spinal Cord Injuries, Metabolic Syndrome, Dietary Modification, Paraplegia
- Trial name
- SCIENCE (NCT03495986)
- Testing
- Functional Electrical Stimulation Leg Cycle Ergometry, Diet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Non-Invasive Stimulation for Improving Motor Function
The purpose of this study is to determine if spinal excitability is increased with a Spinal Associative Stimulation (SAS) protocol, and to determine the functional consequences of this technique on motor recovery.
- Trial name
- NCT03592173
- Testing
- Paired TMS & Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kathleen Friel
Spinal Cord Injuries, Spasticity, Muscle
Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
Spasticity develops months after spinal cord injury (SCI) and persists over time. It presents as a mixture of tonic features, namely increased muscle tone (hypertonia) and phasic features, such as hyperactive reflexes…
- Trial name
- NCT05457205
- Testing
- Electrical neuromodulation
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
Amyotrophic Lateral Sclerosis, Stroke
Telehealth Implementation of Brain-Computer Interface
Determine if Telehealth intervention can allow/empower a caregiver (who is untrained) to effectively implement and utilize a Brain-Computer Interface for communication with a participant who is "Locked in" following progression…
- Trial name
- NCT05951556
- Testing
- Use of BCI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Scale Up of Project Workout on Wheels Internet Intervention (WOWii)
This study is designed is to test the feasibility, fidelity, and effectiveness of scaling up an evidence- and theory-based virtually delivered physical activity intervention (WOWii) for individuals living with chronic SCI for…
- Trial name
- WOWii (NCT05353842)
- Testing
- WOWii Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Craig Hospital
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Spinal Cord Injury
Level and Degree of Spinal Cord Injury and Its Impact on Male Sexual Function
In addition to the motor and sensory functions, sexual function changes after spinal cord injury and is considered one of the most common problems, ranging from a decrease in sexual desire to disturbances of erection, orgasm and…
- Trial name
- NCT02860637
- Testing
- Questionnaires
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
SCI - Spinal Cord Injury
Nutrition and Pain Study
The purpose of this research is to assess the effectiveness of a nutrition intervention on diet quality in managing pain in individuals with spinal cord injury (SCI).
- Trial name
- NCT07179588
- Testing
- Nutrition Education Program, Nutrition Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Tetraplegia
The Effect of Robot Assisted Hand Therapy in Patients With Spinal Cord Injury
Considering the scarcity of studies on robotic hand therapy, it has been seen that larger-scale and long-term follow-up studies are needed.
- Trial name
- NCT05726773
- Testing
- Robot Assisted Therapy, Conventional Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injury
Corticospinal Function After Spinal Cord Injury
The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal…
- Trial name
- NCT02451683
- Testing
- Electrophysiology Assessment of Time Domain, Electrophysiology Assessment of Location, Training with some stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Shirley Ryan AbilityLab
SCI - Spinal Cord Injury
Cardiocentric Inotropic Optimization in Spinal Cord Injury
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected.
- Trial name
- CARDIO-SCI (NCT07871643)
- Testing
- Dobutamine crossover
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury
To achieve our specific aims and hypotheses we will conduct a parallel group mixed methods randomized control trial comparing participation in the TEEMS program with exercise via asynchronous video library equivalent (control).
- Trial name
- TEEMS (NCT07022808)
- Testing
- Synchronous Group exercise, Asynchronous exercise (Control)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Drexel University
Spinal Cord Injuries
Safety and Effectiveness of BM-MSC vs AT-MSC in the Treatment of SCI Patients.
Spinal Cord Injury (SCI) is a devastating condition that leads to permanent functional and neurological deficits in injured individuals.
- Trial name
- NCT02981576
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- Jordan
- Volunteers
- 14 people
- Sponsor
- University of Jordan
Incomplete Spinal Cord Injury, Spinal Cord Injury
Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function in People With Incomplete Spinal Cord Injury.
Previous studies have shown that the neuroplasticity of the residual corticospinal fibers, the motor cortex and the spinal neurons plays an important role in the spontaneous functional recovery of people with neurological or…
- Trial name
- NCT05142943
- Testing
- Visual illusion, Physical exercise
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- University of Valencia
Spinal Cord Injuries, Spinal Cord Diseases
PAS for Lower Extremity Rehabilitation in Tetraplegic Patients
The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles…
- Trial name
- NCT03459885
- Testing
- Paired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Helsinki University Central Hospital
Spinal Cord Injuries, Spinal Cord Injury (SCI), Initial Encounter
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial
Spinal cord injuries (SCI) are among the most catastrophic survivable events experienced by human beings. Affected individuals remain with lifelong neurological impairment involving motor, sensory, bladder and bowel functions…
- Trial name
- PROMPT-SCI II (NCT07472985)
- Testing
- activity-based therapy
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
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