Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury, Chronic, Spinal Cord Injury Cervical
Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury
Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing.
- Conditions
- Spinal Cord Injury, Chronic, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Incomplete Spinal Cord Injury
- Trial name
- Combinatorial (NCT07135583)
- Testing
- Active Comparator: Single Intervention 1, Active Comparator: Single Intervention 2, Respiratory Resistance Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord
The purpose of this study is to examine how delivery of subthreshold electrical stimulation of the spinal cord alters the excitability of neural pathways and consequently movement performance in healthy and spinal cord injured…
- Trial name
- NCT04843137
- Testing
- Cervical Transcutaneous Electrical Spinal Cord Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Spinal Cord Injuries
Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.
- Trial name
- NCT07210437
- Testing
- Tests of sympathetic inhibition, Tests of above level sympathetic activation, Testing of below level sympathetic activation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Spinal Cord Injury, Muscle Spasticity
The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury
The purpose of this study is to determine the effect of penile vibratory stimulation on the muscle spasticity of men with chronic spinal cord injury.
- Trial name
- NCT00223873
- Testing
- Penile Vibratory Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Prospective Survey of Body Mass Index in People With Spinal Cord Injury.
This study is a prospective national survey of body mass index, and includes all patients with a new spinal cord injury hospitalized at Clinic for Spinal Cord Injuries, Rigshospitalet and Spinal Cord Injury Center of Western…
- Trial name
- NCT03369080
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Cord Injuries
Association of Quantitative and Functional Imaging With Clinical Outcome After Spinal Cord Injury
The overall study aim is to provide additional magnetic resonance imaging parameters of the cervical spinal cord, brainstem and brain and a better understanding of changes after spinal cord injury (SCI) and to define new magnetic…
- Trial name
- NCT03886610
- Testing
- Healthy controls, Subacute SCI patients, Chronic SCI patients
- Where
- Switzerland
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI
This study aims to demonstrate the safety and effectiveness of the Eve personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06777576
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Injuries, Spinal Cord
The WISE Trial - Walking Improvement for SCI With Exoskeleton
A randomized, controlled trial comparing exoskeleton gait training with standard gait training or no gait training in community-dwelling participants with chronic incomplete spinal cord injury
- Trial name
- WISE (NCT02943915)
- Testing
- Ekso GT Rehabilitation Therapy, Body Weight Supported (BWS) Treadmill Training
- Where
- 10 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ekso Bionics
Spinal Cord Injury, Spasticity, Muscle
Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury
Following spinal cord injury (SCI), 75% of patients develop spasticity of the limbs characterized by an increase in muscle tone causing severe pain.
- Conditions
- Spinal Cord Injury, Spasticity, Muscle, Brain Injuries
- Trial name
- SpasT-SCI-T (NCT06532760)
- Testing
- Blood sampling
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spinal Cord Injury, Chronic Pressure Ulcers
Subcutaneous Injection and Ultrasonic Dispersion of Cefazolin Into Chronic Pelvic-Region Pressure Ulcers in Persons With Spinal Cord Injury
Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces.
- Trial name
- NCT02584426
- Testing
- Ultrasonic Distribution of Cefazolin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Traumatic Brain Injury
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities.
- Conditions
- Spinal Cord Injuries, Traumatic Brain Injury, Spina Bifida, Cerebral Palsy
- Trial name
- M2M LEADERS (NCT03797378)
- Testing
- eM2M
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury
Carbohydrate Study, Chronic SCI
As people with spinal cord injuries (SCI) get older they become more likely to develop health problems, just like everyone else. However, SCI increases the risk of certain problems.
- Trial name
- NCT00786435
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Spinal Cord Injuries, Neuropathic Pain
Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury
This study will examine the effectiveness of one of two virtual reality treatments on neuropathic pain in individuals with spinal cord injury.
- Trial name
- NCT03735017
- Testing
- Non-Interactive Virtual Reality Walking, Interactive Virtual Reality Walking
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Spinal Cord Injury, Neurogenic Bowel
Time Comparison of Interventions on Bowel Programs in Spinal Cord Injury
The goal of the study is to find out which of three different options (a suppository, a mini enema, or a transanal irrigation device) takes the least amount of time for completing bowel program amongst those who have spinal cord…
- Trial name
- NCT07817199
- Testing
- Suppository, Enemeez, Peristeen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Spinal Cord Injury
Chronic Pain and Brain Activity in Spinal Cord Injury
This study compares five different procedures to see how they affect pain and brain activity. The procedures include neurofeedback, self-hypnosis training, meditation, and two different levels of transcranial direct current…
- Trial name
- NCT01012635
- Testing
- Hypnosis, Meditation, Neurofeedback training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Spinal Cord Diseases, Spinal Cord Injuries
Optimization of Adaptive Rowing Seating
Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities.
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neurodegenerative Disorders, Cerebrovascular Accident With Associated Sequelae
- Trial name
- OARS (NCT07099625)
- Testing
- Adaptive Indoor Rowing Seat, Paddle Sport adaptive seating system
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Incomplete Spinal Cord Injury
A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES
Neuromuscular electrical stimulation (NMES) remains as one of the effective rehabilitation modalities for addressing recovery of neuromuscular function after a spinal cord injury (SCI).
- Trial name
- NCT05243576
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation