Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury, Autonomic Dysreflexia
Treatment of Post-SCI Hypotension
While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters.
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Orthostatic Hypotension, Baroreceptor Integrity
- Trial name
- NCT02919917
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Access-H20: Sensor-driven Smart Faucet Related Study
The objective of the SBIR Phase II study is to evaluate the updated Access-H2O™ system, a sensor-driven smart faucet developed during the Phase I SBIR project, to enhance independent drinking and grooming among individuals with…
- Trial name
- NCT07603258
- Testing
- Water Faucet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Spinal Cord Injury
Different Efficacy Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With SCI in China
The morbidity of spinal cord injury (SCI) is increasing year by year significantly in China. The methods to treat SCI patients in sequela stage update are poor.
- Trial name
- SCI-III (NCT01873547)
- Testing
- cell therapy, rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Spinal Cord Injuries, Reliability
Reliability and Validity of the Spinal Cord Injury Secondary Conditions Scale
People living with spinal cord injury (SCI) experience a range of secondary health conditions that impact their quality of lives.
- Conditions
- Spinal Cord Injuries, Reliability, Validity
- Trial name
- NCT05935943
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Neurogenic Bladder
Incidence of Urinary Tract Infection After Urodynamic Investigation
The purpose of this study is to evaluate the incidence of urinary tract infection after urodynamic investigation and to identify the involved germs.
- Trial name
- NCT01297647
- Testing
- urodynamic examination
- Where
- Switzerland
- Volunteers
- 317 people
- Sponsor
- Balgrist University Hospital
Spinal Cord Injuries
The Impact of Transcutaneous Spinal Cord Stimulation (TSCS) and Gait Training on Walking Function in Patients With Spinal Cord Injury
Aim 1: Determine the neurophysiologic impact of Transcutaneous Spinal Cord Stimulation (TSCS) within a single session. The investigators hypothesize that subjects will demonstrate increased volitional muscle activity and strength…
- Trial name
- TSCS (NCT03384017)
- Testing
- Transcutaneous Spinal Cord Stimulation and Gait Training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injuries
Bone Mineral Density Ekso Therapy Study
Spinal cord injury (SCI) leads to rapid and profound bone loss with large decreases in bone mineral density (BMD) below the level of the lesion.
- Trial name
- NCT03307954
- Testing
- Ekso Therapy (Exoskeleton Suit), Usual Physiotherapy
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Spinocerebellar Ataxia Type 3
Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3
This study evaluates the effectiveness of oral trehalose in alleviating the neuropathological and motor behaviour deficits among patients with SCA3.
- Trial name
- NCT04399265
- Testing
- Trehalose, Maltose
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- National University of Malaysia
Spinal Cord Injuries, Neurogenic Lower Urinary Tract Dysfunction
Time Needed to Perform Intermittent Catheterization in Adults With Spinal Cord Injuries
This study investigates the burden of intermittent catheterization in adult individuals with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI).
- Trial name
- NCT05003999
- Testing
- HPC - SpeediCath ®, Non-HPC - Self-Cath ®
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Andrei Krassioukov
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries
Treatment of Spinal Cord Injuries With (AutoBM-MSCs)vs (WJ-MSCs).
This study aims to assess and compare the safety and effectiveness of Autologous Bone Marrow-Derived MSCs (AutoBM-MSCs) in one group(group A) of SCI who are unlikely to be able to walk independently without treatment after 1 year…
- Trial name
- NCT04288934
- Testing
- Collection and expansion of BM-MSC, VI-SCI evaluation and patients' follow up
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- University of Jordan
Spinal Cord Injuries, Skeletal Muscle Atrophy
Metabolic Health in Individuals With Spinal Cord Injury (SCI)
Individuals with spinal cord injury (SCI) live longer than before and live to an age where metabolic disorders become highly prevalent.
- Conditions
- Spinal Cord Injuries, Skeletal Muscle Atrophy, Metabolic Disease
- Trial name
- SCI (NCT03204240)
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Stiff-Person Syndrome
Randomized Placebo Controlled Trial of IVIg in Glycine Receptor Antibody Positive Stiff-person Syndrome
This is a randomized double-blind controlled trial of intravenous immunoglobulin (IVIg) for glycine receptor antibody positive (GlyRα1) antibody Stiff Person Syndrome (SPS) spectrum disorders.
- Trial name
- NCT03749096
- Testing
- Intravenous Immunoglobulins, Human
- Where
- United States
- Sponsor
- Mayo Clinic
Spinal Cord Injury
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to…
- Trial name
- NCT07223710
- Testing
- Paired Associative Stimulation, Locomotor Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI)
Myobloc Atrophy Study
The present pilot study is designed to assess the extent to which BOTOX and MYOBLOC cause muscle atrophy in spastic patients. The primary objective is to assess whether there is statistically significant difference in muscle…
- Conditions
- Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI), Brain Injury, Tumor
- Trial name
- MAS (NCT02052024)
- Testing
- Botox, MYOBLOC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgetown University
Brain and Central Nervous System Tumors, Chordoma
Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer
RATIONALE: Polyvinylpyrrolidone-sodium hyaluronate gel may lessen the pain of oral mucositis, or mouth sores, in patients undergoing treatment for cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chordoma, Kidney Cancer, Leukemia
- Trial name
- NCT00349024
- Testing
- polyvinylpyrrolidone-sodium hyaluronate gel
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Spinal Cord Injuries, Stroke
Evaluation of an Advanced Lower Extremity Neuroprostheses
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis, Tetraplegia
- Trial name
- LE-IST (NCT00623389)
- Testing
- IST (Implanted Stimulator-Telemeter)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Case Western Reserve University
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury
Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
We propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular and respiratory function as well as the ability to voluntarily control leg movements below…
- Trial name
- NCT02037620
- Testing
- 5-6-5 Specify electrode, Restore Advance Pulse Generator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
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