Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury
A Clinical Study of a Fully Implanted, Wireless and Functional BCI for Upper-Limb Functional Replacement in Tetraplegia Due to Spinal Cord Injury: Efficacy and Safety
This prospective, multicenter, single-arm clinical trial will enroll subjects with tetraplegia secondary to spinal cord injury. An implantable brain-computer interface system for compensatory hand motor function will be used to…
- Trial name
- "Triple-F" BCI (NCT07720882)
- Testing
- "Triple-F" BCI
- Where
- China
- Volunteers
- 32 people
- Sponsor
- NeuroXess Technology (shanghai) Co.,Ltd.
Spinal Cord Injuries
Autologous Bone Marrow Stem Cell Transplantation in Patients With Subacute Spinal Cord Injury
The aim of this study is to evaluate the efficacy and safety of intrathecal administration of autologous mesenchymal stem cells in participants with subacute spinal cord injury.
- Trial name
- NCT05671796
- Testing
- Mesenchymal stem cell transplantation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- SENAI CIMATEC
Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases.
This is a prospective investigation of the effects of Laughter therapy (LT) on perceived stress, self-efficacy, mood and other wellness measures in people with the following neurological conditions: Alzheimer's disease…
- Conditions
- Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Brain Injury, Huntington's Disease
- Trial name
- NCT02750982
- Testing
- Laughter Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown, Theodore R., M.D., MPH
Spinal Cord Injury
Acupuncture for Treatment of Acute Spinal Cord Injury: an Exploratory/Developmental Study
Specific Aim: to implement and evaluate a research protocol for demonstrating the efficacy of Acupuncture Therapy to improve neurological recovery after incomplete SCI compared to a control protocol.
- Trial name
- NCT00432289
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
Spinal Cord Injury, Incomplete Spinal Cord Injury
Evaluation of Robotic Exoskeletons Therapy for Gait Rehabilitation in Patients With Incomplete Spinal Cord Injury.
The objective of the study is to assess the efficacy of the Exo-H2 robotic exoskeleton for walking rehabilitation of people with incomplete spinal cord injury.
- Trial name
- NCT03477123
- Testing
- Walking therapy with Exo-H2 exoskeleton
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Nacional de Parapléjicos de Toledo
Spinal Cord Injuries
Skeletal Muscle Hypertrophy and Cardio-Metabolic Benefits After Spinal Cord Injury
Spinal cord injury (SCI) is a devastating medical problem that affects thousands of civilian and military personnel in the United States.
- Trial name
- NCT02660073
- Testing
- NMES+FES, Control+FES
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- United States Department of Defense
Postpolio Syndrome
Effectiveness of Transcranial Magnetic Stimulation Treatment in Patients Diagnosed With Postpolio Syndrome
This randomized, double-blind, sham-controlled trial evaluated the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex on walking capacity, fatigue, post-polio-related…
- Trial name
- NCT06926270
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Individualized home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ege University
Spinal Cord Injuries
Randomized Controlled Trial on Robotic Exoskeleton in Spinal Cord Injury: Clinical Outcomes and Cortical Plasticity
The recent introduction of robotics for locomotor training in paraplegic patients, and in particular the use of anthropomorphic exoskeletons, has opened new frontiers in rehabilitation.
- Trial name
- NCT03443700
- Testing
- EKSO-GT, Standard neurorehabilitation locomotor training
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Usl di Bologna
Spinal Cord Injuries
Spinal Cord Injury Virtual Coach RCT
The SCI Virtual Coach study has developed an on-screen, human-like character that will provide support, education and coaching to adults with spinal cord injury (SCI) to aid in the prevention of serious secondary conditions like…
- Trial name
- NCT02876666
- Testing
- SCI Virtual Coach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Spinal Cord Injuries, Stroke
Wheelchair Cushion Comparison Study: SAFETY
Purpose: To examine the safety of the use of two wheelchair cushions for healthy individuals with intact sensation and individuals post stroke and spinal cord injury with impaired sensation.
- Conditions
- Spinal Cord Injuries, Stroke, Healthy Adults
- Trial name
- NCT03430375
- Testing
- Alternating air wheelchair cushion, Static air cushion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Spinal Cord Injury, Detrusor Overacitivity
Effects of Sacral and Tibial Stimulation on Bladder Function in Subacute Suprasacral Spinal Cord Injury
Suprasacral spinal cord injury (SCI) frequently leads to neurogenic detrusor overactivity (NDO), resulting in elevated bladder storage pressures, urinary incontinence, and an increased risk of upper urinary tract damage.
- Trial name
- NCT07343583
- Testing
- Transcutaneous Tibial Nerve Stimulation, Transcutaneous Sacral Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D)
Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history.
- Conditions
- Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D), Cardiac Remodeling
- Trial name
- HEART_REMOD_AD (NCT07456722)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathic Pain, Spinal Cord Injury
Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury
We would like to learn if a medicine called "modified-release morphine sulfate" (Avinza) helps reduce Spinal Cord Injury (SCI)-related pain that has lasted a long time.
- Trial name
- NCT00488969
- Testing
- Modified-release morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries
Hyperbaric Oxygen and Orthopedic Comprehensive Treatment for Traumatic Incomplete Spinal Cord Injury in the Plateau
To observe modified Barthel index, American Spinal Injury Association (ASIA) impairment scale grading, sensory score and motor score in patients with incomplete SCI in the plateau using 0.2 MPa HBO combined with pedicle screw…
- Trial name
- NCT03112941
- Testing
- control group, hyperbaric oxygen group
- Volunteers
- 164 people
- Sponsor
- Qinghai University
Spinal Cord Injury
Examination of the Role of Human Exoskeletons in Rehabilitation
Background and Rationale: Traumatic spinal cord injury (SCI) affects approximately 12,400 individuals annually in the USA, predominantly impacting healthy young adults aged 20-40 years.
- Trial name
- REHA-EXO (NCT07669181)
- Testing
- Exoskeleton based gait therapy
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- University of Pecs
Spinal Cord Injuries
Long-term Outcomes and Life Satisfaction of Adults With Pediatric-Onset Spinal Cord Injuries
The purpose of this study is to assess life satisfaction and long-term outcomes (i.e., medical and psychosocial) of adults who sustained spinal cord injuries (SCI) as children or adolescents.
- Trial name
- NCT00876837
- Where
- United States
- Volunteers
- 514 people
- Sponsor
- Shriners Hospitals for Children
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Postpoliomyelitis
Brain Physiology in Polio Survivors
OBJECTIVE: Many persons who survive poliomyelitis develop pain, weakness, and fatigue many decades later. It is not known why some persons develop this syndrome and others do not.
- Trial name
- NCT00080600
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injury, Chronic Pain
VR Mindfulness Training for Veterans With SCI
This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA…
- Trial name
- NCT06587607
- Testing
- VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Neuropathic Pain Due to Spinal Cord Injury
A Safety, Tolerability and Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury
The purpose of this study is to investigate whether V158866 is safe and effective for the treatment of neuropathic pain due to spinal cord injury.
- Trial name
- NCT01748695
- Testing
- V158866
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Brigham and Women's Hospital
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