Clinical trials: Central Spinal Cord Syndrome
Sleep Apnea, Spinal Cord Injuries
Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury
This cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular…
- Conditions
- Sleep Apnea, Spinal Cord Injuries, Spasticity, Muscle, Neuropathic Pain
- Trial name
- NCT05687097
- Testing
- Home-based sleep screening test or hospital-unattended sleep screening test, Cardiovascular beat-to-beat monitoring, ECG monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Incomplete Spinal Cord Injury
The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients
The purpose of this study is to further establish safety and efficacy of the BQ EMF treatment of chronic SCI subjects who demonstrate stability in The Graded and Redefined Assessment of Strength, Sensibility and Prehension…
- Trial name
- NCT04050696
- Testing
- BQ 1.2
- Where
- 3 sites in United States, Israel
- Volunteers
- 8 people
- Sponsor
- BrainQ Technologies Ltd.
Spinal Cord Injuries (Complete and Incomplete)
Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery
This study looks at a treatment called transcutaneous auricular vagus nerve stimulation, or taVNS. taVNS uses a small device worn on the ear to gently stimulate a nerve.
- Trial name
- PIVOTS-Rehab (NCT07562113)
- Testing
- Transauricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury
Dose-Response Effects of Whole Body Vibration on Spasticity and Walking in SCI
This study will enroll people with SCI who have spasticity and some ability to walk. The goal is to understand if standing on a platform and receiving WBV results in decreased spasticity and improved walking ability.
- Trial name
- WBV (NCT02340910)
- Testing
- Short Duration, Long Duration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Shepherd Center, Atlanta GA
Spinal Cord Injuries
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury
Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.
- Trial name
- NCT05181150
- Testing
- Meal test, GIP, GLP-2
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Neuromyelitis Optica, Myelitis, Transverse
A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease)
Neuromyelitis optica (NMO) is a severe demyelinating disease that selectively involves the optic nerves and the spinal cord but usually spares the brain. NMO is considered to have a B cell induced pathogenesis.
- Conditions
- Neuromyelitis Optica, Myelitis, Transverse, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous System
- Trial name
- NCT00304291
- Testing
- Mitoxantrone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- State University of New York at Buffalo
Spinal Cord Injuries
Safety and Efficacy of Autologous Bone Marrow Stem Cells in Treating Spinal Cord Injury
The projected data related to the burden of spinal cord injuries induced limb paralysis in India is quite alarming. This is attributed to the rapid industrialization and economical development in the country.
- Trial name
- ABMST-SCI (NCT01186679)
- Testing
- laminectomy, Intrathecal
- Where
- India
- Volunteers
- 12 people
- Sponsor
- International Stemcell Services Limited
Spinal Cord Injuries
Non-Invasive Stimulation for Improving Motor Function
The purpose of this study is to determine if spinal excitability is increased with a Spinal Associative Stimulation (SAS) protocol, and to determine the functional consequences of this technique on motor recovery.
- Trial name
- NCT03592173
- Testing
- Paired TMS & Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kathleen Friel
Stiff-Person Syndrome
Efgartigimod for Stiff Person Syndrome (ESPS)
The goal of this clinical trial is to examine the proportion of patients with stiff person syndrome with no worsening in stiffness and/or spasms while on efgartigimod-hyaluronidase (EFD) when compared to their current treatment.
- Trial name
- ESPS (NCT06528392)
- Testing
- Efgartigimod
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of South Florida
Spinal Cord Injuries, Stroke
Evaluation of FES+VFBT With Individuals With Lived Experience
Falls are a concern for people living with spinal cord injury (SCI) or stroke. Falls may result in injury and a fear of falling, which often cause people to restrict their mobility and daily activities.
- Trial name
- NCT05744271
- Testing
- FES+VFBT
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University Health Network, Toronto
Chronic Spinal Cord Injury
RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation
Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients.
- Trial name
- RS-01 (NCT05644171)
- Testing
- RESToration Of Rehabilitative function with Epidural spinal Stimulation
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National Neuroscience Institute
Spinal Cord Injuries
Ultrasound and Peripheral Nerve Stimulator Guided Femoral Nerve Block
A pre-post descriptive study was performed to examine the immediate effects of ultrasound (US) guided femoral nerve block with phenol (UGFNBwP) in managing lower limb spasticity of individuals with traumatic spinal cord injury…
- Trial name
- NCT03468439
- Testing
- Femoral nerve block with phenol
- Volunteers
- 14 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Spinal Cord Injury
Physical Performance Measures for Manual Wheelchair Users
The project is intended to modify the Functional Independence Measure (FIM) for manual wheelchair users. It will determine if the new measure is a better measure of community independence for manual wheelchair users than the FIM.
- Trial name
- NCT00011544
- Testing
- Performance Measure
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury
Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI
The goal of this clinical trial is to determine the effect of treatment frequency on the physical recovery of adults with incomplete spinal cord injury.
- Trial name
- NCT07678437
- Testing
- Blood flow-restricted exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Quality Living, Inc.
Spinal Cord Injury, Spinal Cord Injury Thoracic
Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury
This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries: 1.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Thoracic, Spinal Cord Injury/Damage, Spinal Cord Injury T1-L2
- Trial name
- NCT07037628
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Lian-Cing Yan, MSPT
Spinal Cord Injury
Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition
The study will be conducted in two steps: 1. Determination of the Minimal Effective Dose (MED) among the four doses of the panel 2. Estimation of the probability of response associated to the MED.
- Trial name
- RILUSCI (NCT02859792)
- Testing
- Riluzole, Blood Samples
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis, Spinal Cord Injuries
Pilot Study on EEG and Behavioral Effects of Two Different Treatments on Sexual Life
In this study patients with Multiple Sclerosis or Spinal Lesions will participate in two different types of treatments that aim to improve sexual and sentimental life.
- Trial name
- Seteb (NCT05142111)
- Testing
- Therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Spinal Cord Injury
Physical Activity Guidelines for People With Spinal Cord Injury (SCI)
The first evidence-based physical activity guidelines for people with spinal cord injury were released in March, 2011. This project will evaluate the implementation of the new physical activity guidelines in a community exercise…
- Trial name
- NCT01368172
- Testing
- Physical Activity Guidelines
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Spinal Cord Injury
Somato-sensory Reflex Arch in Spinal Cord Injury - Effect on Clinical Outcome
Spinal cord injury (SCI) usually affects young people and causes severe bowel and bladder dysfunction. Recently, the concept of a surgically created somat-sensory reflex arch for bladder dysfunction in SCI has been introduced.
- Trial name
- NCT01241630
- Testing
- Somatosensory reflex arch (Xiao Procedure)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
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