Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injuries
Improving Activity Engagement Among Persons With SCI During COVID-19
During the current COVID-19 pandemic many spinal cord injury (SCI) rehabilitation services are limited to emergency management, leaving those living in the community without access to services.
- Trial name
- NCT04408287
- Testing
- WebEx Physical Activity Program
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Cord Injury
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury.
- Trial name
- NCT01272349
- Testing
- Acute intermittent hypoxia, Room air
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emory University
Spinal Cord Injuries
Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)
The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord…
- Trial name
- NCT06406855
- Testing
- Brain-Computer Interface-Triggered Transcutaneous Spinal Cord Stimulation (BCI-tSCS) System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Stroke
Restorative Neuromodulation for Lower Extremity Functions
The overall objective of the proposed study is to restore lower-extremity functions of paraplegic individuals. Paralysis following Stroke or spinal cord injury (SCI) result harsh sufferings including lifelong dependence on…
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis
- Trial name
- NCT04171375
- Testing
- trans-spinal Electrical Stimulation (tsES)
- Where
- Hong Kong
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Autonomic Dysreflexia, Spinal Cord Injuries
Prevention of Complications Due to Autonomic Dysreflexia in SCI Individuals
Autonomic dysreflexia (AD) is a syndrome of unbalanced response of the sympathetic system to noxious stimuli below the level of spinal cord injury (SCI), characterized by paroxysmal hypertension.
- Trial name
- NCT05024487
- Testing
- Clinical Examination
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Assoc. Prof. Jiri Kriz, MD, PhD
Spinal Cord Injury, Bone Loss
Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury
Spinal cord injury (SCI) results in marked acute loss of bone. This study evaluates the effect of teriparatide (PTH) and the use of vibration as a form of mechanical stimulation on bone mass.
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT01225055
- Testing
- Teriparatide, vibration
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Thomas J. Schnitzer
Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis
Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders
The goal of this study is to use ultra-high-resolution (UHR) PET imaging to better understand how the brain and spinal cord change in healthy aging and in neurological and psychiatric disorders such as Alzheimer's disease (AD)…
- Conditions
- Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT07509125
- Testing
- UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Cord Injuries, Osteoporosis
Simvastatin to Prevent SCI-Induced Bone Loss
This is a double blind, randomized, placebo -controlled clinical trial with the primary goal of determining the osteogenic benefits of simvastatin in acute SCI.
- Trial name
- NCT02946424
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Craig Hospital
Spinal Cord Injury, Neurogenic Detrusor Overactivity
Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity
This is a phase IV, double-blind, multicenter, randomized trial evaluating the efficacy and safety of two M3 receptors antagonists (Trospium Chloride and Darifenacin Hydrobromide) with one standard drug (Oxybutynin Chloride) for…
- Trial name
- NCT00800462
- Testing
- Oxybutynin Cl, Trospium Cl, Darifenacin Hydrogen Bromide (HBr)
- Where
- 2 sites in Canada
- Volunteers
- 23 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injuries, Central Pain Syndrome
Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI
Central neuropathic pain (CNP) is defined as chronic pain due to injury or disease in the central nervous system. This pain is most common among people with a spinal cord injuries (SCI), with a prevalence of about 50%.
- Trial name
- NCT03748290
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Lower Extremity Motor Dysfunction, Spinal Cord Injury
Evaluation of the Effectiveness and Safety of AI-Robotics
Evaluation of the effectiveness and safety of the lower extremity exoskeleton rehabilitation training robot
- Trial name
- ART (NCT03452059)
- Testing
- AiLegs, AiWalker and HKAFO
- Where
- China
- Volunteers
- 40 people
- Sponsor
- AI-Robotics Technology Co., Ltd
Spinal Cord Injuries
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age…
- Trial name
- BO2ST-II (NCT06521723)
- Testing
- Daily acute intermittent hypoxia, Walking + tSTIM
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury, Hypotension
A Dose Titration of Droxidopa in Patients With Spinal Cord Injury
The investigators seek to determine the efficacy, duration of action and safety of escalating dose of droxidopa on systemic blood pressure, cerebral blood flow and vasoactive hormones and catecholamines during upright seated…
- Trial name
- NCT01354158
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Bronx VA Medical Center
Spinal Cord Injuries (SCI)
Reclaiming Independence: Daily Activities and Rehabilitation Goals in Spinal Cord Injury
The purpose of this cross-sectional, observational survey was to assess the importance individuals with Spinal Cord Injury (SCI) in Türkiye place on specific Activities of Daily Living (ADL) and their target levels of…
- Trial name
- NCT07237035
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Medipol University
Spina Bifida Aperta, Acquired Traumatic Spinal Cord Injury
Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury
With improved life expectancy over the last fifty years, spina bifida has become a disease of the adult. One of the major stakes for these patients is the preservation of a regular follow-up of uro-nephrologicals risk factors and…
- Trial name
- ESTIME (NCT01606618)
- Where
- 16 sites in France
- Volunteers
- 111 people
- Sponsor
- Rennes University Hospital
Spinal Cord Injuries
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury
Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.
- Trial name
- NCT05181150
- Testing
- Meal test, GIP, GLP-2
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Locked-in Syndrome, Neuromuscular Diseases
Investigation on the Cortical Communication System
The goal of this clinical trial is to demonstrate communication through a brain implant in people in locked-in state, i.e. people with severe paralysis and communication problems.
- Conditions
- Locked-in Syndrome, Neuromuscular Diseases, Brainstem Stroke, Traumatic Brain Injury
- Trial name
- CortiCom (NCT06207591)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- UMC Utrecht
Spinal Cord Injury, Quadriplegia
Electrical Activation of The Diaphragm for Ventilatory Assist
OBJECTIVES: The objectives of this study are to test the Diaphragm Pacing Stimulation (DPS) System for treating chronic ventilatory insufficiency in persons with respiratory muscle paralysis.
- Trial name
- NCT00010374
- Testing
- NeuRx DPS
- Where
- 5 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Synapse Biomedical
Spinal Cord Diseases
Body Weight Supported Training Study
Successful ambulation at home and in the community is the main goal of gait training after incomplete spinal cord injury. Many different treatment approaches have been recommended to achieve this goal.
- Trial name
- NCT03534518
- Testing
- BWS overground training, BWS treadmill training
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University of Zurich
Multiple Sclerosis, Muscle Spasticity
Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
This study is being conducted to compare the impact of somnolence (sleepiness) on cognition (awareness) as well as the safety and effectiveness of tizanidine hydrochloride capsules versus Zanaflex® (tizanidine hydrochloride…
- Conditions
- Multiple Sclerosis, Muscle Spasticity, Spinal Cord Injury, Stroke
- Trial name
- NCT00047580
- Testing
- tizanidine hydrochloride capsule
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Elan Pharmaceuticals
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