Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injuries
Arm and Leg Cycling for Accelerated Recovery From SCI
The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in…
- Trial name
- NCT05619146
- Testing
- Motor-assisted arms and legs cycling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Shirley Ryan AbilityLab
Poliomyelitis
Serological Survey on Monitoring the Positive Rate After Vaccination of Inactivated Polio Vaccine
The Purpose of this study is to assess the seroconversion using inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) sequential schedule in pilot areas where IPV was phased introduced into national immunization…
- Trial name
- IPV (NCT02643446)
- Testing
- IPV, OPV
- Where
- 5 sites in China
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Tetraplegia/Tetraparesis, Quadriplegia
UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- UAE-PRIME (NCT06992596)
- Testing
- N1 Implant, R1 Robot
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Neuralink Corp
Spinal Cord Injuries
Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians.
- Trial name
- NCT04876794
- Testing
- ABLE Exoskeleton
- Where
- 2 sites in Germany, Spain
- Volunteers
- 24 people
- Sponsor
- ABLE Human Motion S.L.
Neuropathic Back Pain, Spinal Cord Injury
Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury
Back pain is a common secondary condition of both acute and chronic spinal cord injury (SCI). Current existing treatment including both pharmacologic and non-pharmacologic are limited by marginal efficacy or intolerable side…
- Trial name
- NCT02736890
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries, Myofascial Pain Syndrome
Effectiveness of Dry Needling as a Treatment of Shoulder Myofascial Pain Syndrome in Spinal Cord Injury Patients
Shoulder pain in people with spinal cord injury is one of the most prevalent in acute and chronic patients because of weakness in shoulder periarticular muscles, and also because of overuse of these part of the body in assistive…
- Conditions
- Spinal Cord Injuries, Myofascial Pain Syndrome, Shoulder Pain, Puncture
- Trial name
- NCT03709797
- Testing
- Dry needling in infraspinatus muscle
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de León
Wheelchair, Paraplegia
Virtual Peer Coaching in Manual Wheelchair Skills
The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained.
- Conditions
- Wheelchair, Paraplegia, Spinal Cord Injury, Tetraplegia/Tetraparesis
- Trial name
- NCT06295146
- Testing
- Intervention A: 1-on-1 wheelchair skills training by a peer coach, Intervention B: Training via educational videos
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Pittsburgh
Immobilization
Time Performance of Scoop Stretcher Versus Vacuum Mattress for Prehospital Spinal Stabilization
A simulation-based randomized controlled trial was designed with the objective to assess the time needed to achieve spinal stabilization using a scoop stretcher compared to a vacuum mattress.
- Trial name
- NCT04904770
- Testing
- Scoop stretcher, Vacuum mattress
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stuby Loric
Spinal Cord Injuries (SCI)
Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI).
- Trial name
- DOSA-SCI (NCT07739992)
- Testing
- Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milap Sandhu
Spinal Cord Injuries
Feasibility of Exercise and Spinal Cord Injury
The purpose of the study is to examine the impact of a community-based exercise intervention (CBEI) for persons with spinal cord injury (PwSCI) on physiological and psychological well-being and identify barriers and facilitators…
- Trial name
- NCT03941600
- Testing
- Community-based Exercise Intervention group (CBE), Exercise Education Control group (EEG)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury, Gut Dysbiosis
Gut Dysbiosis in Spinal Cord Injury Rehabilitation
The goal of this study is to investigate the role of gut microbiota, and related immune biomarkers and metabolites, in the functional recovery of spinal cord injury patients during the subacute phase.
- Conditions
- Spinal Cord Injury, Gut Dysbiosis, Immune Dysfunction
- Trial name
- SCIMBIONT (NCT06892106)
- Where
- Portugal
- Volunteers
- 106 people
- Sponsor
- Centro Academico Clínico Egas Moniz Health Alliance
Spinal Cord Injuries, Fatigue; Muscle, Heart
Fatigue Induced by Overground Wheelchair Propulsion in Persons With a Spinal Cord Injury: Upper Limb Saving or Straining?
What are the implications of wheelchair propulsion-induced fatigue for the development of shoulder pain and how can this knowledge improve prevention programs? With this project, the "Shoulder Health and Mobility group" of the…
- Trial name
- NCT03153033
- Testing
- Fatigue protocol
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation to Promote Walking Recovery After Spinal Cord Injury
The goal of this clinical trial is to investigate the effects of transcutaneous spinal cord stimulation (TSCS) combined with exoskeleton training, as compared to exoskeleton training alone to improve motor function in individuals…
- Trial name
- NCT05982171
- Testing
- Exo + TSCS
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Craig Hospital
Spinal Cord Injuries, Health, Subjective
Finnish Spinal Cord Injury Study (FinSCI)
The purpose of the Finnish Spinal Cord Injury Study (FinSCI) is to identify factors related to the health and functioning of people with spinal cord injury (SCI), their challenges with accessibility and how such factors are…
- Trial name
- FinSCI (NCT04649814)
- Testing
- Questionnaire
- Where
- Finland
- Volunteers
- 1,773 people
- Sponsor
- The Finnish Association of People with Physical Disabilities
Deep Brain Stimulation, Neuro: Spinal Cord Injury
Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury
The purpose of this study is to evaluate safety of Deep Brain Stimulation (DBS) of the lateral hypothalamus (LH) and whether the use of DBS can increase motor performance in patients with chronic spinal cord injury (SCI).
- Trial name
- HoT-DBS (NCT04965727)
- Testing
- Device implantation
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Jocelyne Bloch
Multiple Sclerosis, Stroke
From Clinic to Community: An Information and Communication Technology (ICT) Home-Based Exercise Training System for Translating Clinical Findings
The specific aim of the study in our example is to conduct a feasibility translational home-based exercise trial established in the LEADERS (R2) project with the TExt-ME tele-exercise training system for participants with…
- Trial name
- TExT-ME (NCT03108950)
- Testing
- Movement to Music
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries
Strengthening Health Systems for Persons With Traumatic Spinal Cord Injury in South Africa and Sweden
A traumatic spinal cord injury (TSCI) often causes an unprecedented change in functioning by altering bodily structure and function.
- Trial name
- NCT03437850
- Testing
- Usual care
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- University of the Western Cape
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Spinal Cord Injuries (SCI), Upper Limb Function
Investigating the Upper Limb During the First 6 Months After Sustaining a Cervical Spinal Cord Injury,
The goal of this observational study is to investigate and describe the injury patterns, secondary complications, and biomechanical properties of the upper limb during the initial 6 months post-SCI.
- Trial name
- In Ul 6 SCI (NCT06740279)
- Testing
- Assessment of upper limb function
- Volunteers
- 210 people
- Sponsor
- Vastra Gotaland Region
Spinal Cord Injuries
Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training
Umbilical cord blood mononuclear stem cells (UCBMSCs) transplant followed by the intensive locomotor training for up to 5±1 hours a day, 5±1 days a week, and for 3-6 months for treatment in patients with chronic, stable and…
- Trial name
- NCT03979742
- Testing
- Umbilical Cord Blood Mononuclear Cell, Locomotor Training
- Where
- 2 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- StemCyte, Inc.
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