Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury
Integrated Tele-exercise for Individuals With Spinal Cord Injury
The objective of this study is to examine the efficacy of an integrated, participant-centered tele-health physical activity program for individuals with SCI on psychological and social factors through a parallel mixed-methods…
- Trial name
- NCT05360719
- Testing
- Group tele-exercise
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Drexel University
Spinal Cord Injury
Treadmill Training for Spinal Cord Injury
This is a trial to test whether treadmill training can be used to improve the "walking" of patients with partial spinal cord injury.
- Trial name
- NCT00006429
- Testing
- body weight-supported treadmill training
- Where
- 7 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bulbocavernosus Reflex, Spinal Cord Injuries
Evaluation of the Bulbocavernosus Reflex After Acute Spinal Cord Injury
The purpose of this study is to evaluate the possibility to use electromyography in acute phase after a traumatic spinal cord injury to measure quantitatively and objectively the bulbocavernosus reflex.
- Trial name
- NCT04316195
- Testing
- Assessment of the bulbocavernosus reflex
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Andréane Richard-Denis
Spinal Cord Injuries
Improving Ventilatory Capacity in Those With Chronic High Level SCI
The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.
- Trial name
- NCT05041322
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Spaulding Rehabilitation Hospital
Acute Stroke, Cervical Spinal Cord Injury
Motor Recovery Training for Hand and Digits in Stroke and SCI
This study will use evaluate a hand therapy device training isolated finger control with engaging video gaming technology to facilitate hand and digit recovery in patients with acute stroke and cervical spinal cord injury.
- Trial name
- NCT04688229
- Testing
- Hummingbird hand training device plus standard of care rehabilitation
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab
Radiating Pain, Myelopathy
Interbody Fusion Devices in the Treatment of Cervicobrachial Syndrome
This study randomizes neck and arm pain patients being treated with discectomy and anterior interbody fusion into two groups: one to receive a new ceramic implant and a control group with a more traditional plastic implant.
- Conditions
- Radiating Pain, Myelopathy, Cervicobrachial Syndrome
- Trial name
- CASCADE (NCT01511445)
- Testing
- Anterior cervical discectomy and fusion (ACDF) with PEEK Cage, Anterior cervical discectomy and fusion (ACDF) with a Valeo CSC Cage
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Amedica Corporation
Incomplete Spinal Cord Injury, Transverse Myelitis
Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance
Robotic therapies aim to improve limb function in individuals with neurological injury. Modulation of robotic assistance in many of these therapies is achieved by measuring the extant volitional strength of limb muscles.
- Trial name
- NCT05249595
- Testing
- Surface electromypgraphy-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Surface electromypgraphy and ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Spinal Cord Injury (SCI)
Restoring Walking in Non-ambulatory Children With Severe Chronic Spinal Cord Injury (SCI) (Kids STEP Study)
The Kids STEP Study aims to 1. Determine if walking can be restored in children with incomplete SCI and little to no leg movement 2. Identify the neural pathways that permit recovery of walking
- Trial name
- NCT00488280
- Testing
- Locomotor Training
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Osteoporosis, Bone Loss
Romosozumab in Women With Chronic SCI
This two-year open-label pilot clinical trial will evaluate the efficacy and safety of romosozumab to treat bone loss in females with chronic spinal cord injury (SCI) and osteoporosis (OP).
- Conditions
- Osteoporosis, Bone Loss, Osteopenia, Osteoporosis, Spinal Cord Injuries
- Trial name
- NCT04708886
- Testing
- Romosozumab, Alendronate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Tetraplegia
Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation
Patients with C5 or C6 tetraplegia have paralysis of the triceps brachii. Elbow extension can be surgically restored by transferring the tendon from a preserved muscle onto the tendon of the paralyzed triceps brachii.
- Trial name
- MouvSupReaTetr (NCT03513783)
- Testing
- measurement of human movement
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Nantes University Hospital
Spinal Cord Injury, Chronic Spinal Cord Injury
First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury
This study aim to investigate the safety and exploratory efficacy of STUP-001 which is AAV-based spinal cord injury investigational product.
- Trial name
- STUP-001 (NCT06922890)
- Testing
- STUP-001
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Yonsei University
Spinal Cord Injuries, Stroke
Adapting MHealth Technology to Improve Patient Activation
Persons with disabilities (PwD) commonly experience fatigue, which often negatively impacts their everyday lives. Management of this symptom can be challenging.
- Conditions
- Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- NCT04893590
- Testing
- Fatigue self-management SMS intervention
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries
Energetic Response to Feeding and Exercise in SCI
This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI).
- Trial name
- CRIT (NCT03545867)
- Testing
- Seated control (CON), Moderate intensity continuous (MICT), High intensity interval training (HIIT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries (SCI), Paralysis, Lower Limbs
Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation
Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence.
- Trial name
- EPISTIM-SCI (NCT06847295)
- Testing
- Epidural Electrical Stimulation (EES) using an implanted paddle lead and pulse generator combined with a 12-month intensive rehabilitation program.
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Spinal Cord Injuries
The Relationship Between Ambulation Capacity and Piriformis Muscle in Patients With Chronic Spinal Cord Injury
Spinal cord injury (SCI) is a neurological condition causing paralysis, sensory abolishmentS and deficits including circulatory, respiratory, otonomic nervous systems, bowel and bladder functions.
- Trial name
- NCT05829837
- Testing
- Ultrasonographic evaluation
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Spinal Cord Injury
Pilot Study: The Role of Macrophage Migration Inhibitory Factor (MIF) in Spinal Cord Injury
The purpose of the study is to investigate inflammatory and other substances that may be elevated in the blood and blood cells following spinal cord injury (SCI).
- Trial name
- NCT00919581
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Northwell Health
INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied
Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
- Trial name
- NCT06906536
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Primary Lateral Sclerosis
Screening and Natural History: Primary Lateral Sclerosis and Related Disorders
Objective: The objectives of this protocol are: to develop and maintain a repository of clinically characterized patients with primary lateral sclerosis for future research protocols, to characterize the natural history of…
- Trial name
- NCT00015444
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injury
Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation
Spinal cord injury (SCI) is a severe neurological condition characterized by the loss of motor and sensory functions due to damage in the spinal cord or the nerves branching from it.
- Trial name
- NCT07019207
- Testing
- VR-Based Dual-Task Training with Motor Imagery, VR-Based Dual-Task Training without Motor Imagery, Proprioceptive Neuromuscular Facilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University
Stroke, Brain Injuries, Traumatic
Evaluation of a Novel Gait Training Device to Support Body Weight
A novel body weight support device that uses pressurized pants may provide advantages in delivering gait therapy. The objectives of this study are to test the following hypotheses that 1) the novel device will allow for increased…
- Conditions
- Stroke, Brain Injuries, Traumatic, Spinal Cord Injuries, Gait Disorders, Neurologic
- Trial name
- NCT03171207
- Testing
- Lite Run Gait Trainer, Current Harness System
- Volunteers
- 10 people
- Sponsor
- Lite Run Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.