Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury
Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation
Spinal cord injury (SCI) is a severe neurological condition characterized by the loss of motor and sensory functions due to damage in the spinal cord or the nerves branching from it.
- Trial name
- NCT07019207
- Testing
- VR-Based Dual-Task Training with Motor Imagery, VR-Based Dual-Task Training without Motor Imagery, Proprioceptive Neuromuscular Facilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University
SCI - Spinal Cord Injury
Vagus Nerve Stimulation (VNS) in Spinal Cord Injury (SCI) Adaptive Follow-On Study
This study is an open label extension of the SCI EFS clinical trial (NCT04288245) that developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury.
- Trial name
- SCI-AFOS (NCT06351111)
- Testing
- Active VNS
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
SCI - Spinal Cord Injury
Gut-Brain Neural Coupling in Spinal Cord Injury
The purpose of this research is to determine the effects of food on brain and stomach activity in persons with and without spinal cord injury (SCI).
- Trial name
- NCT07052344
- Testing
- Preload condition, Ad-libitum control condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Miami
Immobilization
Time Performance of Scoop Stretcher Versus Vacuum Mattress for Prehospital Spinal Stabilization
A simulation-based randomized controlled trial was designed with the objective to assess the time needed to achieve spinal stabilization using a scoop stretcher compared to a vacuum mattress.
- Trial name
- NCT04904770
- Testing
- Scoop stretcher, Vacuum mattress
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stuby Loric
SCI - Spinal Cord Injury, Cardiovascular Risk Factor
Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study
The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood…
- Trial name
- NCT03352505
- Where
- 2 sites in Austria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Spinal Cord Injuries, Urinary Bladder, Neurogenic
Mirabegron and Oxybutynin Safety and Efficacy Trial in Spinal Cord Injury
The purpose of this research study is to determine the effectiveness and safety of mirabegron compared to oxybutynin chloride immediate release (oxybutynin IR) for a condition called neurogenic detrusor overactivity in…
- Trial name
- MOSET-SCI (NCT03187795)
- Testing
- Oxybutynin Chloride IR, Mirabegron
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury
Objective: This study's primary objective is to evaluate the efficacy and feasibility of mechanical ventilation with high vs. low tidal volume (Vt) in people with acute spinal cord injury (SCI).
- Trial name
- NCT04912583
- Testing
- High tidal volume, Low tidal volume
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acquired Brain Injuries, Spinal Cord Injury
Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders
This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD).
- Conditions
- Acquired Brain Injuries, Spinal Cord Injury, Multiple Sclerosis, Parkinson Disease
- Trial name
- NeuroVR (NCT06838975)
- Testing
- VR Training, traditional cognitive and motor rehabilitation following standard clinical practices
- Where
- 2 sites in Italy
- Volunteers
- 328 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Spinal Cord Injuries
Feeding Regulation in SCI
The overall purpose of this research is to understand the reasons why persons with spinal cord injuries eat more calories than they need to "burn", stay alive, and function.
- Trial name
- NCT05406739
- Testing
- Test Meals
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Acute Traumatic Spinal Cord Injury
NEUROwave - Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury
It has been hypothesized that there are two mechanisms of acute traumatic spinal cord injury (SCI): the primary mechanical damage and the secondary injury due to additional pathological processes initiated by the primary injury.
- Trial name
- NCT04474106
- Testing
- Shock waves, dummy head
- Where
- 15 sites in Austria
- Volunteers
- 246 people
- Sponsor
- AUVA
Spinal Cord Injury
Study on Functional Electrical Stimulation (FES) Cycling Following Spinal Cord Injury
This research is being done to study the effect of Functional Electrical Stimulation (FES) cycling on factors in blood and spinal cord in people with spinal cord injury (SCI).
- Trial name
- CURE-SCI (NCT01217047)
- Testing
- FES Cycling, Cycling without FES, Lumbar puncture
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injuries
Protein Supplementation and Neuromuscular Electrical Stimulation in Persons With SCI
The aim of this pilot study is to explore how body composition, circulating markers of metabolic health and skin integrity in persons with a spinal cord injury (SCI) are affected by 12 weeks of quadriceps neuromuscular electrical…
- Trial name
- NCT05249985
- Testing
- NMES, Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Spinal Cord Injuries, Amputation, Traumatic
Treatment of Chronic Pain After Spinal Cord Injury (SCI) or Amputation
Pain is a major problem for people after spinal cord injuries and amputations. This is a study to test how pain is affected by adding methadone to a six-week program of weekly physical therapy, relaxation training and counseling.
- Conditions
- Spinal Cord Injuries, Amputation, Traumatic, Pain
- Trial name
- NCT00006448
- Testing
- cognitive therapy, Physical Therapy, Methadone
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spinal Cord Injury
Motor Learning in a Customized Body-Machine Interface
People with tetraplegia often retain some level of mobility of the upper body. The proposed study will test the hypothesis that it is possible to develop personalized interfaces, which utilize the residual mobility to enable…
- Trial name
- BMI (NCT01608438)
- Testing
- Customizing the Body-Machine Interface
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Shirley Ryan AbilityLab
Sleep Apnea, Breathing Disorder During Sleeping
Sleep Apnea in Paralympic Ontario-Resident aThletes With Spinal Cord Injury (SPORTS) Study
This single arm clinical trial will assess whether continuous positive airway pressure (CPAP) therapy in the management of moderate-to-severe sleep-related breathing disorders (SRBDs) among para-athletes living with…
- Conditions
- Sleep Apnea, Breathing Disorder During Sleeping, Sleep Disorder, Spinal Cord Injuries
- Trial name
- NCT06195878
- Testing
- CPAP Therapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Motor Disorders, Healthy
Non-invasive BCI-controlled Assistive Devices
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery…
- Conditions
- Motor Disorders, Healthy, Spinal Cord Injuries, Muscular Diseases
- Trial name
- NCT05183152
- Testing
- NMES Feedback, Visual Feedback, TESS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Spinal Cord Injuries (SCI)
Epidural Electrical Stimulation in Spinal Cord Injury
The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) in motor and sensory function Reconstruction in chronic spinal cord injury (SCI) patients classified as ASIA…
- Trial name
- NCT07105878
- Testing
- Epidural Electrical Stimulation, Standard Rehabilitation Therapy, positron emission tomography-computed tomography (PET-CT)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Spinal Cord Injury
Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury
Individuals with chronic cervical SCI are known to have a restrictive ventilatory defect due to complete or partial loss of respiratory muscle innervation which is dependent upon the level and completeness of injury [2].
- Trial name
- NCT01353599
- Testing
- Mometasone furoate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Effects of 5HTP on the Injured Human Spinal Cord
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity.
- Trial name
- 5-HTP only (NCT04520178)
- Testing
- 5-Hydroxytryptophan 100 MG, 5-Hydroxytryptophan, Carbidopa
- Where
- 2 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- University of Alberta
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