Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injuries
Psychometric Properties of Sit-to-stand Test in Spinal Cord Injury
1. Do different arm placements (including arms on armrests/devices, arms on knees, arms free, and arm crossed over chest) influence outcomes of sit-to-stand test (STST) in ambulatory individuals with spinal cord injury (SCI)? 2.
- Trial name
- NCT03625193
- Where
- Thailand
- Volunteers
- 182 people
- Sponsor
- Khon Kaen University
Autonomic Nervous System Disease, Spinal Cord Injuries
The Effects of an Acute High-intensity Exercise on Heart and Brain Function in People With Spinal Cord Injury
The heart and brain are regulated by the autonomic nervous system. Control of these organs can be disrupted in people with spinal cord injury (SCI).
- Conditions
- Autonomic Nervous System Disease, Spinal Cord Injuries, Cognition
- Trial name
- NCT06274658
- Testing
- High-intensity interval exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Spinal Cord Injury
Hypothermia Following Acute Spinal Cord Injury
The purpose of this study is to investigate the long term outcome of patients who receive hypothermia treatment for spinal cord injury.
- Trial name
- NCT01739010
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Miami
Spinal Cord Injury
Development of an Ergonomic Wheelchair Pushrim
The purpose of this study is to test the effectiveness of newly designed ergonomic manual wheelchair handrims called the Natural-Fit and PalmRim when compared to a new standard handrim.
- Trial name
- NCT00392860
- Testing
- Natural-Fit, PalmRim, Handrim Control Group
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Pittsburgh Healthcare System
Spinal Cord Injury
Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
We propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular and respiratory function as well as the ability to voluntarily control leg movements below…
- Trial name
- NCT02037620
- Testing
- 5-6-5 Specify electrode, Restore Advance Pulse Generator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
Alpha-Thalassemia, Beta-Thalassemia
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a completely virtual, nationwide, real-world observational study to collect, annotate, standardize, and report clinical data for rare diseases.
- Conditions
- Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06539169
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- xCures
Spinal Cord Injury
Corticospinal Function After Spinal Cord Injury
The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal…
- Trial name
- NCT02451683
- Testing
- Electrophysiology Assessment of Time Domain, Electrophysiology Assessment of Location, Training with some stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury, Obesity
Effect of Intense Multi-modal Training on Bone Health and Quality of Life in Persons With Spinal Cord Injury
Bone loss is a common secondary complication of spinal cord injury (SCI), and treatments used to reverse this condition have equivocal effectiveness.
- Trial name
- NCT01386762
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- California State University, San Marcos
Spinal Cord Injuries
Assessment of a Robotic Exoskeleton for Upper Limb Rehabilitation
Rehabilitation robotics has the potential to facilitate rehabilitation at home and empower people with spinal injuries to self-manage increasing their independence and improving their quality of life.
- Trial name
- Exo4UL (NCT05615766)
- Testing
- Experimental: Device Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Liverpool
Spinal Cord Injuries
Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies.
- Trial name
- NCT00559494
- Testing
- Minocycline, SCPP augmentation, SCPP control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Spinal Cord Injuries, Pain, Chronic
Hypnotic Cognitive Therapy Reduce Acute & Chronic SCI Pain in Inpatient Rehabilitation
Chronic spinal cord injury (SCI) pain is complex and difficult to treat. For individuals with SCI, pain often begins early in the course of their SCI and continues longitudinally.
- Conditions
- Spinal Cord Injuries, Pain, Chronic, Spinal Cord Injury, Acute
- Trial name
- HYPCT (NCT05047120)
- Testing
- Hypnosis enhanced cognitive behavioral therapy, Pain Education
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Washington
Spinal Cord Injuries, Spinal Cord Diseases
Sub-study to Spinal Cord Stimulation to Restore Cough
Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00995215
- Testing
- Spinal Cord Stimulation, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injury
Enhancing Quality of Life Through Exercise: A Tele-Rehabilitation Approach
Pilot randomized controlled trial evaluating a Self-Determination Theory (SDT) video-based tele-rehabilitation physical activity intervention aimed to enhance basic psychological needs, motivation, physical activity (PA), and…
- Trial name
- NCT02833935
- Testing
- Physical Activity Intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Craig H. Neilsen Foundation
Spinal Cord Injuries
Early BOTOX After Spinal Cord Injury
The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI.
- Trial name
- NCT06793683
- Testing
- Bladder chemodenervation (Botox)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Paraplegia, Spinal, Spinal Cord Trauma
Cardiovascular Effects of High Intensity Interval Training in Individuals With Paraplegia
The study seeks to determine whether high intensity interval training has an effect on cardiovascular parameters in wheelchair users with paraplegia.
- Trial name
- HIIT (NCT04378218)
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Spinal Cord Injury
Walk-Training Program for Individuals With Chronic Spinal Cord Injury (SCI)
Cardiovascular disease (CVD) is the common leading cause of death among people with spinal cord injury (SCI) and occurs at an early age in people with SCI as compared to able-bodied people.
- Trial name
- NCT03940274
- Testing
- walking training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Kansas Medical Center
Spinal Cord Injuries
Comparison of Three Different Assisting Devices to Power Manual Wheelchairs in Patients With Spinal Cord Injury
The purpose of this study is to compare three assisting devices to propel personal wheelchairs (Servomatic A©, Servomatic B© and E.Motion©) to the standard personal manual wheelchair in patients with spinal cord injury.
- Trial name
- PAPAW (NCT02244931)
- Testing
- Servomatic™ assisting device, E.Motion© assisting device, Standard manual Wheelchair
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurological Disorders, Wheelchair Mobility
Evaluation of the Wheelchair School (Drivkraft) a Clinical Study
This project will evaluate the Wheelchair School with the Drivkraft Methodology in a clinical setting. Participants are adults with chronic neurological diagnoses.
- Conditions
- Neurological Disorders, Wheelchair Mobility, Rehabilitation
- Trial name
- NCT07131553
- Testing
- Wheelchair school, Comparison group, conventional rehabilitation
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Injury, Spinal Cord
The Crosstalk Between the Epigenome and Mitochondria in SCI
SCI is a devastating neurological disorder for which there are not yet restorative therapies. Thus, there is a need to explore new therapeutic strategies to treat SCI patients.
- Trial name
- CEM-SCI (NCT06537427)
- Testing
- Data collection
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bone Blood Flow Regulation
Exploration of Blood Flow Regulation to Bone in Humans
Without blood flow, bone cannot maintain its integrity. Bone blood flow responds to various local and systemic factors, however, bone perfusion in humans remains relatively unstudied.
- Trial name
- NCT04083794
- Testing
- Laboratory based assessments
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
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