Clinical trials: Central Spinal Cord Syndrome
Acute Spinal Cord Injury of Traumatic Origin (tSCI)
Surgical Treatment for Spinal Cord Injury
Despite many years of research, an incomprehensible amount of scientific efforts worldwide and billions of dollars invested, no effective therapy resulting in major neurological or functional recovery is available to date for…
- Trial name
- SCI-POEM (NCT01674764)
- Testing
- Early surgical intervention, Late surgical intervention
- Where
- 17 sites in Austria, Bulgaria and 10 more
- Volunteers
- 297 people
- Sponsor
- AOSpine Europe
Supra-sacral Spinal Cord Injury, Spinal Cord Injury
CBD for Lower Urinary Tract Dysfunction in Spinal Cord Injury
The goal of this feasibility study is to learn whether Cannabidiol (CBD) can improve urinary incontinence and other symptoms in people with recent spinal cord injury (SCI).
- Conditions
- Supra-sacral Spinal Cord Injury, Spinal Cord Injury, Urinary Incontinence
- Trial name
- NCT06840899
- Testing
- CBD
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses
Ublituximab (also known as LFB-R603) is a monoclonal antibody that specifically binds to the trans-membrane antigen CD20. The binding induces immune response that causes lysis of B cells.
- Trial name
- NCT02276963
- Testing
- Ublituximab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
SCI - Spinal Cord Injury
Epidural Stimulation After Neurologic Damage: Long-Term Outcomes
This study will evaluate the long-term effect of chronic spinal cord stimulation to restore volitional movement for patients with chronic spinal cord injuries.
- Trial name
- LTO (NCT05705453)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Spinal Cord Injury
Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury.
- Trial name
- NCT06691165
- Testing
- Low oxygen therapy (LOT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Glen Foster
Spinal Cord Injuries, Multiple System Atrophy, Parkinson Variant
Transcutaneous Spinal Cord Stimulation Home Study
The goal of this pilot clinical trial is to examine the safety and feasibility of SCONE as home based therapy for orthostatic hypotension and bowel dysfunction in individuals with spinal cord injury or multiple system atrophy.
- Trial name
- NCT06838637
- Testing
- Spinal COrd NEuromodulation ("SCONE") Device
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Michael Berger
Spine Injury, Cord Injury, Spinal
The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).
- Conditions
- Spine Injury, Cord Injury, Spinal, Cord Infarction Spinal, Incomplete Spinal Cord Injury
- Trial name
- NCT06552507
- Testing
- Duroplasty
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injuries, Paraplegia and Tetraplegia
Effects of Transvertebral Direct Current Stimulation in Humans
This study will evaluate the effects of non-invasive stimulation of the spinal cord in people with spinal cord injury.
- Trial name
- NCT04586777
- Testing
- transvertebral direct current stimulation (tvDCS)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Kentucky
Spinal Cord Injuries, Spinal Diseases
Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury
Currently, Enoxaparin is the usual prophylactic anticoagulant treatment at the acute and sub-acute phases of spinal cord injury (SCI).
- Trial name
- NCT05484557
- Testing
- Apixaban, Enoxaparin Sodium
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Loewenstein Hospital
SCI - Spinal Cord Injury, Incomplete Spinal Cord Injury
Stimulation to Enhance Walking Post-SCI
This pilot study will investigate the effects of transcutaneous direct current stimulation (tsDCS) on walking function in individuals with incomplete spinal cord injury.
- Trial name
- NCT03702842
- Testing
- Soterix Medical tsDCS stimulator, Locomotor training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Spinal Cord Injury
Combined Tibial Nerve Stimulation and Standing for People With SCI
The goal of this clinical trial is to understand how sensory inputs from the lower leg can influence pelvic floor muscle function and urogential function in adults with chronic spinal cord injury (SCI).
- Trial name
- NCT07429305
- Testing
- Standing + Tibial Nerve Stimulation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
Spinal Cord Injury Virtual Coach RCT
The SCI Virtual Coach study has developed an on-screen, human-like character that will provide support, education and coaching to adults with spinal cord injury (SCI) to aid in the prevention of serious secondary conditions like…
- Trial name
- NCT02876666
- Testing
- SCI Virtual Coach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Spinal Cord Injuries
The Effectiveness of the Wim Hof Method in People with Spinal Cord Injury
People with a spinal cord injury (SCI) often experience secondary medical complications. One of the methods that may help to prevent or deal with secondary complications in people with SCI is the Wim Hof Method (WHM).
- Trial name
- NCT05704322
- Testing
- Wim Hof Methode
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stichting Reade
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Diaphragmatic Pacer Placement: Anesthetic Management (DP)
The diaphragmatic pacemaker (DP) has proven its utility in replacing mechanical ventilation (MV) in patients with chronic spinal cord injury (SCI) and Amyotrophic Lateral Sclerosis (ALS), by improving the patients quality of life…
- Conditions
- Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Respiratory Paralysis
- Trial name
- DP (NCT02942953)
- Testing
- Diaphragmatic Pacer
- Volunteers
- 16 people
- Sponsor
- Institut Guttmann
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Energetic Response to Feeding and Exercise in SCI
This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI).
- Trial name
- CRIT (NCT03545867)
- Testing
- Seated control (CON), Moderate intensity continuous (MICT), High intensity interval training (HIIT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injury
Functional Magnetic Micturition in Patients w/SCI
This project will determine the ultimate usefulness of functional magnetic stimulation (FMS) as an assistive device for voiding in patients with SCI.
- Trial name
- NCT00011557
- Testing
- Assistance in Voiding
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Design and Delivery Preferences for Exercise Intervention in People With Spinal Cord Injury
This research study aims to explore people's understanding of physical activity behavior and perceptions of what a physical activity program should include for supporting initiation and continuous participation.
- Trial name
- NCT06578780
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Spinal Cord Injuries, Neuropathic Pain
Cingulotomy for Refractory Neuropathic Pain Following Spinal Cord Injury (CRNP-SCI)
Neuropathic pain is very common following a spinal cord injury, estimated to affect 43% of patients after 6 months. A proportion of these patients do not respond to treatment and there remains an unmet need to treat people with…
- Trial name
- CRNP-SCI (NCT05084170)
- Testing
- Bilateral anterior cingulotomy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- St George's, University of London
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