Clinical trials: Cephalalgia
Acute Migraine
Long-term Safety Study of BHV-3500 (Zavegepant*) for the Acute Treatment of Migraine
The purpose of this study is to evaluate the long-term safety of BHV-3500/vazegepant intranasal in the acute treatment of migraine. BHV-3500, formerly "vazegepant", is now referred to as "zavegepant" (za ve' je pant).
- Trial name
- NCT04408794
- Testing
- Zavegepant (BHV-3500)
- Where
- 67 sites in United States
- Volunteers
- 974 people
- Sponsor
- Pfizer
Bruxism
TMJ-1001 Bruxism Run-In/Pivotal Trial
The study is an open-label, prospective, multi-center, randomized, two treatment parallel, comparison study of the TMJ NextGeneration(TM) and custom-fit occlusal splint in the reduction of nocturnal bruxism episodes and monthly…
- Trial name
- NCT02269553
- Testing
- TMJ(TM) NextGeneration, Standard Hard TMJD Splint
- Sponsor
- TMJ Health
Migraine
Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults
This Phase 2 trial will evaluate the efficacy and safety of ABP-450 for migraine prevention in adults who suffer from six or more migraine days per month.
- Trial name
- NCT04845178
- Testing
- ABP-450
- Where
- 62 sites in United States, Australia and 1 more
- Volunteers
- 797 people
- Sponsor
- AEON Biopharma, Inc.
Chronic Cluster Headache
A Study Comparing the Efficacy and Safety of Fremanezumab (TEV-48125) for the Prevention of Chronic Cluster Headache (CCH)
The purpose of the current study is to evaluate the efficacy and safety of Fremanezumab (TEV-48125), in the prevention of CCH in adult participants.
- Trial name
- NCT02964338
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 259 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
High Frequency, High Disability Migraine
Pathway M-1: Sphenopalatine Ganglion Stimulation for the AcuteTreatment of High Disability Migraine Headache
The purpose of the clinical study is to evaluate the use of an implanted sphenopalatine ganglion (SPG) neurostimulator for the treatment of migraine headache pain, migraine headache symptoms and migraine frequency in high…
- Trial name
- Pathway M-1 (NCT01540799)
- Testing
- ATI Neurostimulation System
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 80 people
- Sponsor
- Autonomic Technologies, Inc.
Primary Headache Disorder
Feasibility of a Developmentally-tailored Mobile App for Tracking Mood and Pain in Children With Migraine
This study aims to inform the continued development of a mobile app intended to support the treatment of CYP with migraine. After extensive public and patient involvement, Happyr Health has developed a mobile app that allows…
- Trial name
- NCT05337930
- Testing
- Happyr App
- Where
- United Kingdom
- Sponsor
- Happyr Ltd
Migraine, Headache
Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches
The purpose of this study is to compare the effectiveness and safety of two treatment regimens in preventing migraines. The antidepressant amitriptyline has been used successfully to prevent migraine headaches.
- Trial name
- NCT00210821
- Testing
- topiramate
- Volunteers
- 347 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine
A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis
This study will provide additional efficacy data for rizatriptan when used for an acute migraine attack in patients already taking topiramate for migraine prophylaxis.
- Trial name
- NCT00812006
- Testing
- rizatriptan benzoate
- Volunteers
- 108 people
- Sponsor
- Organon and Co
Migraine Disorders
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
A 6-month, observational, post authorization safety study for the collection and evaluation of additional safety data on topiramate as a prophylactic treatment for migraines in adult patients.
- Trial name
- NCT00297336
- Testing
- Topiramate
- Volunteers
- 80 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Migraine Disorders
Phase I, Open Label, Single-Dose, Four Way Crossover Study to Compare the PK of NP101 With Oral Imitrex® (50mg) in Migraine Subjects During an Acute Migraine Attack and During a Non-Migraine Period
To compare the pharmacokinetics of NP101 with a currently approved oral formulation of Imitrex® (50 mg) in migraine subjects both during an acute migraine attack and during a non-migraine period.
- Trial name
- NP101-011 (NCT00723983)
- Testing
- Sumatriptan succinate, NP101 Study Patch
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- NuPathe Inc.
Migraine With Aura, Migraine Without Aura
Migraine With and Without Aura Characteristics and Response to Remote Electrical Neuromodulation (REN) Treatment
This is a Post-marketing, real-world evidence study investigating the safety and efficacy of the acute treatment of migraine with a Remote Electrical Neuromodulation (REN) device (Nerivio) in migraine patients with and without…
- Trial name
- NCT06023953
- Testing
- Nerivio device
- Where
- Israel
- Volunteers
- 31,715 people
- Sponsor
- Theranica
Acute Treatment of Migraine
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
The purpose of the study is to learn about safety and how the body processes the study medicine called Zavegepant (PF-07930207) in children with a history of migraine.
- Trial name
- NCT06995729
- Testing
- Zavegepant
- Where
- 14 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pfizer
Migraine
A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in Healthy Adults
The purpose of this study is to assess the bioequivalence of an alternative ODT formulation (ODT2) versus the approved ODT formulation of a CGRP receptor antagonist in healthy adult participants under fasting conditions.
- Trial name
- NCT07594769
- Testing
- ODT2 Test formulation, ODT Reference formulation
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Migraine
A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of UB-313 in Healthy Participants
This first in-human (FIH) study of UB-313, an anti-calcitonin gene-related peptide based immunotherapeutic candidate, is designed to assess the safety, tolerability, and immunogenicity of 4 selected UB-313 dose regimens in…
- Trial name
- NCT05477095
- Testing
- UB-313
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vaxxinity, Inc.
Migraine, Without Aura
TREXIMET (Formerly Known as TREXIMA) for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1)
This study was designed to determine the efficacy and tolerability of TREXIMET (formerly known as TREXIMA) compared to placebo for the acute treatment of probable migraine, a sub-type of migraine.
- Trial name
- NCT00387881
- Testing
- sumatriptan succinate / naproxen sodium
- Where
- 70 sites in United States
- Volunteers
- 679 people
- Sponsor
- GlaxoSmithKline
Migraine
A Randomized, Sham-controlled Study of gammaCore ® (nVNS) for Prevention of Episodic Migraine
A prospective, double-blind, randomized, sham-controlled, multicentre investigation.
- Trial name
- NCT02378844
- Testing
- gammaCore®-R
- Where
- 22 sites in Belgium, Denmark and 6 more
- Volunteers
- 477 people
- Sponsor
- ElectroCore INC
Intractable Chronic Migraine
Peripheral Nerve Stimulation Registry for Intractable Migraine Headache
The purpose of this study is to evaluate the long-term safety and performance of neurostimulation for the treatment of intractable chronic migraine as well as to detect infrequent complications or problems only apparent in…
- Trial name
- Relief (NCT02227758)
- Where
- 18 sites in Belgium, Germany and 4 more
- Volunteers
- 112 people
- Sponsor
- Abbott Medical Devices
Migraine
A Proof of Concept Alleviating the Symptoms of Photosensitive Migraine.
This proof of concept clinical study will investigate the efficacy of active lens with frame in alleviating the symptoms of migraine which are caused by photosensitivity.
- Trial name
- NCT04904328
- Testing
- Lumishade® Active Lens
- Volunteers
- 77 people
- Sponsor
- Mitsui Chemicals, Inc.
Migraine Disorders, Chronic Migraine Headache
EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
EMBRACE-OBS is the first phase of the EMBRACE research program. This single-site observational registry accesses and analyzes patient-reported outcome data already collected through routine clinical care from adults with migraine…
- Conditions
- Migraine Disorders, Chronic Migraine Headache, Migraine
- Trial name
- EMBRACE-OBS (NCT07652034)
- Testing
- Middle Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cortex Neurovascular
Migraine
Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks
National clinical trials, phase III, randomized, open, parallel, study of superiority, in which three hundred thirty-six (336) participants of both sexes, aged between 18 and 65 years will be randomly allocated to one of two…
- Trial name
- NCT02582996
- Testing
- Acetaminophen+Caffeine+Dihydroergotamine+Metoclopramide., Acetaminophen
- Where
- 6 sites in Brazil
- Volunteers
- 336 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.