Clinical trials: Cephalalgia
Migraine
Study of Pediatric Migraine: The Pediatric Migraine Registry
This is a multi-center registry that will prospectively collect regulatory compliant data from children and adolescents with migraine.
- Trial name
- NCT03742024
- Where
- 19 sites in United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Post-Dural Puncture Headache, Headache After Spinal Puncture
Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach
This randomized controlled trial will compare two commonly used techniques for performing spinal anesthesia, the median (midline) approach and the paramedian (lateral) approach, in adult patients undergoing elective orthopedic or…
- Trial name
- NCT07436403
- Testing
- Spinal anesthesia using median approach (midline), Spinal anesthesia using paramedian approach
- Where
- Pakistan
- Volunteers
- 142 people
- Sponsor
- Mayo Hospital Lahore
Postdural Puncture Headache
Pregabalin in Treatment of Postdural Puncture Headache
Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke.
- Trial name
- NCT06271486
- Testing
- Pregabalin 75mg, An epidural blood patch (EBP), conservative treatment.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Migraine, Migraine With Aura
PRIMA PFO Migraine Trial
The purpose of this study is to evaluate migraine headache frequency in subjects who have migraine with aura and a patent foramen ovale (PFO, a slit-like opening between the right and left upper chambers (atria) of the heart…
- Conditions
- Migraine, Migraine With Aura, Patent Foramen Ovale, PFO
- Trial name
- PRIMA (NCT00505570)
- Testing
- AMPLATZER® PFO Occluder Device
- Where
- 17 sites in Canada, Germany and 2 more
- Volunteers
- 107 people
- Sponsor
- Abbott Medical Devices
Temporomandibular Disorder, TMJ Disc Displacement With Reduction
Telerehabilitation for TMD
This study will compare after physical therapy for Temporomandibular Disorders (TMD) performed either in-person or virtually using telerehabilitation.
- Conditions
- Temporomandibular Disorder, TMJ Disc Displacement With Reduction, TMJ Disc Displacement Without Reduction, Masticatory Myofascial Pain
- Trial name
- NCT05318313
- Testing
- Telerehabilitation
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Minnesota
Migraine, Headache
Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine
Crossover, randomized, double blind: Q12h dosing in both periods; matching placebo for evening dosing during XR treatment; target dose: 100mg
- Trial name
- NCT03280342
- Testing
- IR-TPM (Topamax), XR-TPM (Trokendi XR)
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Primary Headache
Dexamethasone Plus Metoclopramide Versus Paracetamol/NSAIDs for Primary Headache
Primary headache disorders are among the most common neurological conditions presenting to emergency departments and can significantly impair quality of life and daily functioning.
- Trial name
- DMPH (NCT07605065)
- Testing
- Dexamethasone Plus Metoclopramide, Paracetamol/NSAIDs
- Volunteers
- 94 people
- Sponsor
- Pak Emirates Military Hospital
Acute Pain, Abdominal Pain
Comparison of Ketorolac at Three Doses in Children With Acute Pain
Hospital Scene #1: A 6-year-old arrives in the Emergency Department at McMaster Children's Hospital (MCH) complaining of pain in his lower right side.
- Conditions
- Acute Pain, Abdominal Pain, Migraine, Appendicitis Acute
- Trial name
- KETODOSE (NCT05641363)
- Testing
- Ketorolac Tromethamine
- Where
- 2 sites in Canada
- Volunteers
- 171 people
- Sponsor
- Hamilton Health Sciences Corporation
Migraine
A Study to Evaluate the Long-Term Safety of M207 in the Acute Treatment of Migraine
This is an open-label, twelve-month safety study. There is a screening period followed by a run-in period to record migraine activity.
- Trial name
- ADAM (NCT03282227)
- Testing
- M207 Microneedle System
- Where
- 31 sites in United States
- Volunteers
- 342 people
- Sponsor
- Zosano Pharma Corporation
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Myofascial Trigger Points
A Clinical Observation on Electrophysiology in Headache Patients With Myofascial Trigger Points
Through an observational, cross-sectional study, muscle activity was compared among 21 subjects with episodic headache, 17 subjects with chronic headache and 17 age-matched healthy controls.
- Trial name
- NCT03890393
- Testing
- Electromyography
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Neck Pain, Myofacial Pain Syndrome
Efficacy of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients With Neck Pain
Study Title: Evaluation of the Effectiveness of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients with Neck Pain Due to Upper Trapezius Trigger Points: A Single-Blind Randomized Controlled Trial Purpose…
- Conditions
- Neck Pain, Myofacial Pain Syndrome, Trigger Point Pain, Myofascial, Trigger Points
- Trial name
- NCT07058636
- Testing
- 2% Lidocaine HCl + saline, Steroid+lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Ischemic Stroke, Patent Foramen Ovale
Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence
A patent foramen ovale (PFO) is found more frequently in patients with an ischemic stroke than in control subjects. Therapeutic options to prevent stroke recurrence include antiplatelet drugs, oral anticoagulants, and…
- Conditions
- Ischemic Stroke, Patent Foramen Ovale, Atrial Septal Aneurysm, Migraine
- Trial name
- CLOSE (NCT00562289)
- Testing
- aspirin, Antivitamins K or rivaroxaban or dabigatran or apixaban, Devices for PFO closure
- Where
- France
- Volunteers
- 664 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Migraine
Abortive Treatment of Migraine With the Cefaly® Abortive Program Device
The purpose of this study is to investigate the efficacy of the Cefaly® Abortive Program device used at home for 2 hours to treat a migraine attack.
- Trial name
- NCT03217968
- Testing
- Cefaly® Abortive Program device
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Cefaly Technology
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study
Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07292090
- Testing
- Intervention yogabased movements
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Head and Neck Carcinoma
Interdisciplinary Interventions to Address Pain Management Among Head and Neck Cancer Patients
This phase II trial compares different pain management interventions (standard of care [SOC], neurofeedback [NFB] training, and compassionate high alert team [CHAT]) in patients diagnosed with head and neck cancer who are at risk…
- Trial name
- NCT05077072
- Testing
- Best Practice, Counseling, Electroencephalography
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Traumatic Brain Injury
The Relationship Between Obesity and Chronic Headache
The relationship between obesity and the development of chronic headache after traumatic brain injury will be investigated.
- Trial name
- NCT06445595
- Testing
- patients with traumatic brain injury
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Karaman Training and Research Hospital
Migraine, Migraine Disorders
Healthy Living Partnerships for Veterans With Migraine
This pilot study, modeled upon the successful and empirically validated HELP Prevent Diabetes Intervention, incorporates a migraine education component describing the links between lifestyle behaviors and migraine activity (e.g.…
- Conditions
- Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura
- Trial name
- HELP-VM (NCT04373330)
- Testing
- Intensive Lifestyle Intervention
- Sponsor
- Wake Forest University Health Sciences
Migraine
Psychological and Biological Markers of Refractory Migraine
The term "refractory" migraine describes a particularly aggressive form of the disease in which the patient does not benefit from any of the preventive therapies with the various classes of drugs available, including treatment…
- Trial name
- NCT05046119
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
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