Clinical trials: Cephalalgia
Migraine
Evaluation of Pain Thresholds in Migraine Patients After Inhalation of Essential Oils: a Randomized Clinical Trial
This study will test whether inhaling essential oils can change how sensitive people with migraine are to pressure pain. Participants will be allocated to inhale lavender, peppermint, a combination of both, or a control solution…
- Trial name
- NCT07493434
- Testing
- Lavander essential oil, Peppermint essential oil, Lavandula angustifolia and Mentha Piperita
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Chronic Pain, Headache, Migraine
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Study Purpose: This study will explore the feasibility of administering Holographic Memory Resolution® (HMR) to adults who are experiencing chronic pain for 6 months or more.
- Conditions
- Chronic Pain, Headache, Migraine, Stress Disorders, Post-Traumatic
- Trial name
- NCT05001399
- Testing
- Holographic Memory Resolution® (HMR)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Billings Clinic
Migraine Disorders
Magnesium, Partenium, Andrographis, Co-enzyme Q10 and Riboflavin (PACR) in Migraine Prophylaxis
Migraine is a highly disabling disorder that affects hundreds of millions of people around the world. Yet, a little number of prophylactic treatments are available still now.
- Trial name
- ParMig (NCT03190044)
- Testing
- PACR
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Trigger Point, Tension-Type Headache
EFFECTS OF MIOFASCIAL RELEASE AND PERCUTANEOUS MICROELETROLYSIS IN TYPE HEADACHE
A headache is a more common disorder and one that prevails over a lifetime of much of the population. Among the causes are in the stress and spasms of the pericranial musculature, presence of painful sensitivity in the region…
- Trial name
- EMRPMITH (NCT03225053)
- Testing
- MEP® technique
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rodrigo Marcel Valentim da Silva
Migraine
Efficacy of Erenumab on Functional Impact of Migraine
The purpose of this study is to assess the efficacy of erenumab on functional impact due to Migraine in adults.
- Trial name
- NCT04465357
- Testing
- Erenumab-Aooe 140 MG/ML [Aimovig]
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Merle Diamond
Headache
The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers
To measure the cerebral hemodynamic effect of L-kynurenine.
- Trial name
- NCT03212430
- Testing
- L-kynurenine
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Temporomandibular Disorder, Headache Disorders
Validation of the TMD Pain Screener in a Specialized Headache Center
The purpose of the study is to investigate whether a questionnaire can be used to detect whether patients referred to the Danish Headache Center have a painful temporomandibular disorder (TMD).
- Trial name
- NCT04193111
- Testing
- TMD pain screener
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Post-Dural Puncture Headache
Trans-nasal Sphenopalatine Ganglion Block Versus Ultrasound-guided Bilateral Greater and Lesser Occipital Nerve Block for Management of Post-Dural Puncture Headache.
Post-Dural Puncture Headache (PDPH) is a complication associated with spinal anesthesia. While conventional treatments are available, the Epidural Blood Patch (EBP) is considered the gold standard.
- Trial name
- TNSPGB /GALONB (NCT06705244)
- Testing
- Trans-nasal sphenopalatine nerve block, Greater and lesser occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Migraine Without Aura
Myotensive Extraocular Muscle Techniques Added to Manual Therapy for Migraine Without Aura
Migraine without aura is a highly prevalent and disabling primary headache that significantly affects quality of life. Many patients experience insufficient symptom control with pharmacological treatments or develop adverse…
- Trial name
- NCT07254598
- Testing
- Myotensive Extraocular Muscle Techniques + Manual Therapy, Standard Manual Therapy
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Facultad de Enfermería, Fisioterapia y Podología (FEFP)
Migraine With Aura, Stroke
Induction of Migraine Aura With Cilostazol
In a double blind placebo-controlled cross-over study the effect of cilostazol on aura induction and endothelial response is tested in patient with migraine with aura.
- Trial name
- NCT02253004
- Testing
- Cilostazol
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Herlev Hospital
Migraine
Investigation of Functional Brain Features in Women with Migraine
This study aims to investigate whether the functional alterations in the brain of individuals with migraine appear before the peripheral vascular changes.
- Trial name
- NCT06470958
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Tension-Type Headache, Chronic Tension-type Headache
Efficacy of a Multimodal Physiotherapy Program and Mobile-App Guided Meditation in Adults With Frequent or Chronic Tension-Type Headache
The goal of this clinical trial is to evaluate whether a multimodal physiotherapy program and guided meditation using a mobile app can help reduce headache pain and improve quality of life in adults with frequent or chronic…
- Conditions
- Tension-Type Headache, Chronic Tension-type Headache, Frequent Episodic Tension-Type Headache
- Trial name
- JBE-CEF (NCT07240532)
- Testing
- Multimodal Physiotherapy for Tension-Type Headache, Guided Meditation Using Insight Timer App
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Universidad de Granada
Acute Pain
Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial
Post dural puncture headache is a distressing issue, many measures tried to treat symptoms but few delt with prevention.
- Trial name
- NCT06493838
- Testing
- intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping., Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.
- Volunteers
- 180 people
- Sponsor
- Minia University
Headache
Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
This study will randomly assign emergency department patients seeking treatment for a headache to one of three groups. The first group will receive standard emergency care as determined by the treating physician, the second group…
- Trial name
- NCT00856232
- Testing
- Medical Air, Oxygen
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Chronic Migraine
Efficacy and Safety of Cyclobenzaprine Hydrochloride Extended Release for the Treatment of Chronic Migraine
The primary objective of the study is to evaluate the effectiveness and safety of cyclobenzaprine hydrochloride extended release (Amrix 15mg/day) for the prophylaxis of chronic migraine compared to a placebo medication.
- Trial name
- NCT01151787
- Testing
- cyclobenzaprine hydrochloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Kennedy Medical Group
Migraine
Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine
This is a prospective, randomized, vehicle-controlled, double-blind, multi-center study assessing the safety, tolerability, and efficacy of B244 delivered as an intranasal spray for preventive treatment in subjects with episodic…
- Trial name
- NCT03488563
- Testing
- B244, Vehicle
- Where
- 22 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Episodic Migraine, Chronic Migraine
Aspirin Resistance in Women With Migraine
The purpose of this study is to compare the rates of aspirin resistance (high residual platelet reactivity) between women with episodic and chronic migraine and women without migraine.
- Trial name
- ARWM (NCT01257893)
- Testing
- Aspirin (acetylsalicylic acid)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Benign Headache
Bupivacaine for Benign Headache in the ED
Headache is a common chief complaint of patients presenting to the emergency department (ED), accounting for approximately 3 million ED visits per year.
- Trial name
- NCT01785459
- Testing
- 0.5% bupivacaine, Standard Care
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences
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