Clinical trials: Cephalalgia
Cervicogenic Headache
Cervical-Cranial Dry Needling vs. Orthopedic Manual Therapy for Cervicogenic Headache
Dry needling is a therapeutic modality used to treat a number of neuromusculoskeletal conditions. Practice trends suggest it is becoming widely used by Physical Therapists to help patients manage symptoms associated with CGH…
- Trial name
- NCT03583190
- Testing
- Cervical-cranial dry needling, Orthopedic manual therapy, Thoracic Manipulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Youngstown State University
Primary Headaches (Includes Migraines, Tension, Cluster Headaches)
Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches
The purpose of this study is to determine if droperidol is equally as effective as metoclopramide for treatment of primary headaches in the Emergency Department.
- Trial name
- NCT01406860
- Testing
- Droperidol, Metoclopramide + diphenhydramine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Colic, Infantile, Migraine
Infants Colics : Towards a Migrainous Origin ?
According to recent studies, we want to find evidences that infant colics could be a episodic symptom associated to migraine as cyclic vomiting syndrome or abdominal migraine are.
- Conditions
- Colic, Infantile, Migraine, Migraine Equivalents
- Trial name
- COLIGRAINE (NCT03155360)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Migraine
Impact of Combined Oral Contraceptive Pills on Migraine
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.
- Trial name
- NCT06509503
- Testing
- Combined oral contraceptive, Vaginal Ring
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Kafrelsheikh University
Cervicogenic Headache
Thrust Joint Manipulation and Reverse SNAGS (Sustained Natural Apophyseal Glides) in Cervicogenic Headache
The purpose of the study was to compare the effect of upper cervical thrust joint manipulation and reverse Sustained Natural apophyseal Glide on intensity of pain, pain pressure threshold, range of motion and headache disability…
- Trial name
- NCT04521218
- Testing
- Thrust Joint Manipulation, Reverse Sustained Natural apophyseal glides
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Migraine Without Aura
Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura
This is a a multi-center, randomized, double-blind, parallel group, and placebo controlled, two-arm study of a single oral dose of NXN-188 for the treatment of acute migraine headache without aura.
- Trial name
- NCT00959751
- Testing
- NXN-188
- Where
- 4 sites in United States
- Volunteers
- 195 people
- Sponsor
- NeurAxon Inc.
Post-Traumatic Headache
Abobotulinumtoxina Efficacy in Post-Traumatic Headache
This study will evaluate the efficacy of abobotulinumtoxina on Veterans with post-traumatic headache
- Trial name
- NCT03928496
- Testing
- AbobotulinumtoxinA, Normal saline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Neck Pain, Headache
Muscle Position and Dry Needling Efficacy
Currently, no previous studies have investigated how the position of a muscle before dry needling may influence the outcome and effectiveness of the treatment.
- Trial name
- NCT07629141
- Testing
- Dry needling technique with the shoulder in full adduction., Dry needling technique with the shoulder in 90° abduction.
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- University of Alcala
Epidural Anesthesia, General Anesthesia
Thoracic Epidural Versus General Anesthesia for Laparoscopic Cholecystectomy
Eighty two patients planned to undergo elective laparoscopic cholecystectomy were divided into two groups, T and G, randomly. In Group T all patients underwent laparoscopic cholecystectomy under thoracic epidural anesthesia with…
- Trial name
- NCT04721054
- Testing
- Thoracic epidural effect on heart rate in Laparoscopic Cholecystectomy (bupivacaine and lignocaine), general anesthesia effect on heart rate in Laparoscopic Cholecystectomy
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Armed Forces Hospital, Pakistan
Myasthenia Gravis, Guillain-Barre Syndrome
Neurology Inpatient Clinical Education Trial
The objective of this study is to compare the effectiveness of a personalized patient education program to the current hospital education and evaluate its impact using patient satisfaction scores.
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis, Seizures
- Trial name
- NCT03826056
- Testing
- Current standard discharge educational intervention, Personalized discharge educational intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Migraine Headache
Testing myWHI: Online Self-guided Programs for Migraine
The goal for this pilot study is to assess the acceptability of two online self-guided programs for migraines. The programs are part of the investigators' collection of "my Wireless Headache Interventions" (myWHI).
- Trial name
- NCT02710942
- Testing
- SPHERE, PRISM
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- IWK Health Centre
Acute Migraine
Efficacy and Safety of Acetaminophen and Aspirin Versus Placebo in the Acute Treatment of Migraine
The purpose of the study is to evaluate the efficacy and safety of acetaminophen and aspirin versus placebo in the acute treatment of migraine
- Trial name
- NCT01973205
- Testing
- Acetaminophen 250 mg and Aspirin 250 mg
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- Novartis
Healthy Volunteers Only
Effects of Substance P on Headache Induction in Healthy Individuals
Substance P is a signaling molecule that has been implicated in the pathogenesis of headache. This study aims to ascertain whether administration of substance P can induce headache in healthy adults.
- Trial name
- NCT06632080
- Testing
- Substance P
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Headache, Fasting
Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache
The investigators intend to study whether the use of the pain medication etoricoxib (Arcoxia) taken just before the Ramadan fast will prevent or lessen headache that some people get while fasting.
- Conditions
- Headache, Fasting, Fasting Headache, Ramadan Headache
- Trial name
- NCT01148303
- Testing
- Etoricoxib
- Where
- Israel
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Migraine
Comparing Efficacy and Safety of 2 Dose Regimens of Subcutaneous Administration of TEV-48125 Versus Placebo for the Preventive Treatment of Chronic Migraine
The study is being conducted to evaluate two doses of TEV-48125 in adult patients with chronic migraine
- Trial name
- NCT02621931
- Testing
- Fremanezumab
- Where
- 273 sites in United States, Canada and 7 more
- Volunteers
- 1,130 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Migraine
Assessment of LBR-101 In Chronic Migraine
The purpose of the study is to determine whether monthly subcutaneous administration of LBR-101 (fremanezumab) is safe and provides migraine prevention in patients with chronic migraine.
- Trial name
- NCT02021773
- Testing
- LBR-101 High Dose, LBR-101 Low Dose
- Where
- 57 sites in United States
- Volunteers
- 264 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Disorders
MigraineManager: An Individualized Self-Management Tool for Adolescents With Migraine
The purpose of the study is to develop, evaluate, and optimize "MigraineManager", the first web-based comprehensive self-management tool for adolescents with migraine, their parents, and clinicians.
- Trial name
- NCT03157739
- Testing
- MigraineManager: Individualized Self-Management Tool
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine Disorders, Migraine, Classic
Understanding the Pathophysiology of Migraine Pain
Migraine is the most common headache disorder, prevalent in 18% of females and 6% of males. Emergency room visits, physician consults, hospitalizations, medications, and indirect costs such as lost work days and decreased…
- Conditions
- Migraine Disorders, Migraine, Classic, Migraine Without Aura
- Trial name
- NCT03026101
- Testing
- Nitroglycerin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Migraine Headache
Examining the Efficacy of Kiko Exercises on the Prevention of Migraine Headaches
This pilot study hopes to show that after 3 months of Kiko training, Kiko naive patients with migraine will have a decrease in the frequency and severity of their migraines.
- Trial name
- NCT03651583
- Testing
- Kiko exercises-combines breathing and movement
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Regional Clinical Research
PFO, Cognitive
Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale
This investigator-initiated, single-center prospective study is designed to clarify how patent foramen ovale (PFO) relates to brain function abnormalities in patients with drug-refractory migraine with aura (MA), and whether…
- Conditions
- PFO, Cognitive, Cognitive Functions, Migraine
- Trial name
- NEURO-PFO (NCT07343154)
- Volunteers
- 45 people
- Sponsor
- Second Xiangya Hospital of Central South University
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