Clinical trials: Cephalalgia
Healthy Volunteers, Tension-type Headache
A Study to Describe Pain Intensity, Pain Relief and Safety of Neosaldina in the Treatment of Tension-type Headaches (TTH) in Healthy Participants
The purpose of this study is to describe pain relief in TTH with Neosaldina treatment.
- Trial name
- NCT03666858
- Where
- 5 sites in Brazil
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Takeda
Migraine, Magnesium, Pediatric
Serum Magnesium Level and Pediatric Migraine
Aim: The purpose of this study is to compare serum magnesium levels between patients with migraine and a control group and to examine the relationship between the frequency and duration of attacks in patients with migraine and…
- Trial name
- Migraine (NCT06274255)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
Headache Migraine Chronic
A PIVOTAL STUDY EVALUATING SAFETY AND EFFICACY OF THE SHIRATRONICS MIGRAINE THERAPY SYSTEM
Prospective, multi-center, double blind, randomized, sham-controlled study to evaluate neuromodulation in patient with chronic migraine.
- Trial name
- NCT06167655
- Testing
- Neurostimulator
- Where
- 23 sites in United States, Australia
- Volunteers
- 250 people
- Sponsor
- ShiraTronics
Adult Brain Tumor, Headache
Prevalence of Post-craniotomy Headache in Siriraj Hospital
Headache after major craniotomy may be a problem in taking care of the patients. The investigators want to identify the incidence of headache after major craniotomy and also the risk factors.
- Trial name
- NCT01806155
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Episodic Migraine, Prophylaxis
The Role of Left Prefrontal Transcranial Magnetic Stimulation in Episodic Migraine Prophylaxis
The aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rTMS) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical treatment.
- Trial name
- NCT04031781
- Testing
- repetitive transcranial magnetic stimulation (rTMS) 100% motor threshold, repetitive transcranial magnetic stimulation (rTMS) 50% motor threshold
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Migraine
Study of Telcagepant (MK-0974) in Participants With Moderate to Severe Acute Migraine With or Without Aura (MK-0974-011)
The purpose of this study is to investigate the efficacy and safety of telcagepant (MK-0974) compared to an approved medication for acute migraine.
- Trial name
- NCT00442936
- Testing
- Telcagepant potassium 150 mg, Telcagepant potassium 300 mg, Zolmitriptan 5 mg
- Volunteers
- 1,380 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine, Tension-Type Headache
Muscle Function and Strength Training of the Neck and Shoulder in Migraine and Tension-type Headache Patients. A Singel Arm Open Label Trial
A Single-Arm Open-Label Trial was performed at the Danish Headache Center (DHC), Department of Neurology, Rigshospitalet - Glostrup as part of the clinic.
- Conditions
- Migraine, Tension-Type Headache, Neck Pain
- Trial name
- MUST-MITH (NCT06112587)
- Testing
- strength training
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Danish Headache Center
Migraine
Substance P-Induced Migraine Attacks Without Aura
Substance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura.
- Trial name
- NCT06959004
- Testing
- Substance P
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Oral Contraceptive, Headache
Effect of a New Oral Contraceptive Pill on Hormone Related Symptoms Such as Pelvic Pain and Headache
The aim of the present study is to investigate whether women taking a new combined oral contraceptive pill (SH T00658ID, estradiol valerate/dienogest) experience fewer hormone withdrawal-associated symptoms such as pelvic pain or…
- Conditions
- Oral Contraceptive, Headache, Pelvic Pain
- Trial name
- NCT00778609
- Testing
- EV/DNG (Qlaira, BAY86-5027)
- Where
- 63 sites in Australia, Finland and 7 more
- Volunteers
- 449 people
- Sponsor
- Bayer
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Episodic Migraine Headache
Craniocervical Flexion Training for Reducing Migraine Headaches and Disability
Migraine, a leading cause of disability globally, necessitates effective interventions beyond pharmacotherapy due to the associated risks.
- Trial name
- NCT06751732
- Testing
- Craniocervical Flexion Training (CCFT), Diaphragm Respiratory Training, Cervical Mobilization and Traction
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Migraine
Sphenopalatine Ganglion Blocks RCT
RCT of Sphenopalatine Ganglion (SPG) Blocks using anesthetics vs. placebo for migraine.
- Trial name
- SPGblock (NCT03666663)
- Testing
- Lidocaine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Migraine
Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care
This study, which is aimed at comparing the effectiveness of the most frequently used drugs in the first line in primary care for the preventive treatment of migraine (amitriptyline, flunarizine, topiramate and propranolol), is a…
- Trial name
- PREMI (NCT06499116)
- Testing
- Topiramate, Flunarizine, Amitriptyline
- Volunteers
- 460 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Post-Traumatic Headache
Hypersensitivity to Phosphodiesterase 3 Inhibition in Post-Traumatic Headache
To investigate whether cilostazol (phosphodiesterase 3 inhibitor) induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
- Trial name
- NCT05595993
- Testing
- Cilostazol
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine
Study of EVO756 in Adults With Migraine
This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.
- Trial name
- NCT07616128
- Testing
- EVO756, Dose 1, EVO756, Dose 2
- Where
- 35 sites in United States, Canada and 1 more
- Volunteers
- 330 people
- Sponsor
- Evommune, Inc.
Headache
Utilization of 60-Day Peripheral Nerve Stimulation of the Occipital Nerves for the Treatment of Headache
This prospective observational cohort study will evaluate clinical outcomes and health care resource utilization among adults who, independent of research participation, are clinically scheduled to undergo temporary 60-day…
- Trial name
- NCT07553533
- Testing
- Occipital nerve peripheral nerve stimulation (PNS)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Yale University
Headache, Migraine, Chronic Migraine Headache
Stellate Ganglion Blockade for Refractory Chronic Migraine
Stellate Ganglion Block (SGB) is an interventional anesthetic technique used to treat pain conditions affecting the head, face, neck, and upper extremities by temporarily blocking sympathetic nerve output.
- Trial name
- SGB-RCM (NCT06891118)
- Testing
- Procedure/Surgery: Ultrasound-Guided Stellate Ganglion Block
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine Without Aura
Study the Effect of Acupuncture on Migraine Patient Without Aura Via Functional Magnetic Resonance Imaging.
This study recruits 30 subjects into three groups, including two experimental groups and one control group. The two experimental groups receive acupuncture treatment for 4 weeks and two times functional magnetic resonance imaging…
- Trial name
- NCT04636359
- Testing
- Acupuncture stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Migraine Disorders, Chronic Migraine
HD-EEG Connectivity Changes in Migraine Patients Undergoing Treatment With Anti-CGRP mAbs
Migraine is a leading cause of disability with an estimated prevalence of 12% in Europe. The headache field witnessed a breakthrough since the introduction of specific preventive therapies which proved effective and well…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- NCT06155123
- Testing
- Monoclonal antibody targeting the CGRP pathway (ligand or receptor) (mAbs)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
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