Clinical trials: Cephalalgia
Migraine
A Study of Galcanezumab (LY2951742) in Adults With Treatment-Resistant Migraine
The purpose of this study is to assess the safety and efficacy of galcanezumab in people with treatment-resistant episodic or chronic migraine.
- Trial name
- CONQUER (NCT03559257)
- Testing
- Galcanezumab
- Where
- 69 sites in United States, Belgium and 11 more
- Volunteers
- 463 people
- Sponsor
- Eli Lilly and Company
Pain
Ibuprofen Versus Ibuprofen Plus Caffeine in the Treatment of Migraine.
Primary Objective: To compare the treatment groups in the reduction of pain score by at least 30 mm on a visual pain scale (VAS) at 60 minutes after study medication intake, compared to the baseline score (obtained before the…
- Trial name
- NCT01426971
- Testing
- IBUPROFEN + CAFFEINE, IBUPROFEN
- Sponsor
- Sanofi
Headache, Migraine
Intranasal Ketorolac Trial
The purpose of this study is to determine if intranasal (IN) Ketorolac in combination with oral Prochlorperazine and Diphenhydramine is non-inferior to current migraine management which involves use of intravenous (IV) Ketorolac…
- Trial name
- NCT06083571
- Testing
- Ketorolac, Prochlorperazine, Diphenhydramine
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Migraine Disorders
Reliability of Rimegepant or Triptans for the Acute Treatment of Migraine
This protocol describes the analysis of the Adelphi Real World (ARW) Migraine Disease Specific Programme(TM) 2022, a cross-sectional study which used both physician and patient surveys to assess the perception of the acute…
- Trial name
- Adelphi DSP (NCT06412965)
- Where
- United States
- Volunteers
- 528 people
- Sponsor
- Pfizer
Migraine Headache, Oxygen
Oxygen in Migraine Treatment
IIn this study, the investigators planned to investigate effectiveness of supplemental oxygen in patients (18-65 years) who were diagnosed as headache related to migraine without aura in the emergency department (ED).
- Trial name
- NCT05780671
- Testing
- oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Migraine
RELAXaHEAD for Headache Patients (Phase III)
This study is a fully powered, remote randomized control trial to evaluate RELAXaHEAD in people with migraine.
- Trial name
- NCT06077838
- Testing
- RELAXaHEAD Smartphone App Version 1, RELAXaHEAD Smartphone App Version 2
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Migraine Without Aura
PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients
- Trial name
- NCT00380263
- Testing
- PACAP38
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center
Migraine, Cluster Headache
Intranasal Cooling for Cluster Headache and Migraine
This study will be looking at the clinical efficacy of using a intranasal evaporative cooling device in providing relief of the symptoms of migraine and cluster headache.
- Trial name
- COOLHEAD (NCT01898455)
- Testing
- RhinoChill intranasal cooling
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Migraine
MLD10 in the Prevention of Migraine in Adults
This is a double-blind, placebo-controlled, randomized, multi-center study. Subjects agreeing to participate in the study and meet the entry criteria assessed at the screening visit, will begin a 28 day baseline period to confirm…
- Trial name
- NCT02322333
- Testing
- MLD10
- Where
- 9 sites in United States
- Volunteers
- 157 people
- Sponsor
- Pharmalyte Solutions LLC
Migraine
A Study to Learn About the Safety and Effects of Rimegepant to Prevent Migraine in Chinese Subjects.
The purpose of this study is to learn about the effects of Rimegepant to help prevent migraine. This study is seeking for participants who: Are male and female of 18 years of age or older.
- Trial name
- NCT05810038
- Testing
- Rimegepant
- Where
- 49 sites in China
- Volunteers
- 787 people
- Sponsor
- Pfizer
Refractory Chronic Headache Disorders
French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders
The purpose of this non interventional research is to set up a French database, initially for 3 years, of patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal…
- Trial name
- NGO (NCT01842763)
- Where
- 16 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Migraine
Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine
The goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (IAV) versus placebo (inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) for treating nausea associated with acute…
- Trial name
- NCT05175521
- Testing
- Eucalyptus Oil Scent, Isopropyl Alcohol Vapors
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- HonorHealth Research Institute
Migraine Disorders
(Italian Migraine Registry, I-GRAINE-NEW)
Rationale Understanding the mechanisms and evolution of migraine is hampered by its nature as a chronic "evolutionary" condition.
- Trial name
- I-GRAINE-NEW (NCT07163416)
- Where
- Italy
- Volunteers
- 2,030 people
- Sponsor
- IRCCS San Raffaele Roma
Headache Disorders, Primary
The Effect of Aerobic Exercise Training for Migraine Prevention.
This study has been designed in order to know the effect of 12 weeks of aerobic exercise training for migraine prevention. We hypothesized that the exercise training could reduce the number of days with migraine and the number of…
- Trial name
- NCT01972607
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Myofascial Temporomandibular Disorder, Bruxism, Sleep
Factors Affecting Patients With Myofascial Temporomandibular Disorders
The aim of the study was to assess and compare the relationship between jaw function, neck disability, sleep quality, fatigue, and headache in patients with myofascial Temporomandibular Disorder (TMD) with Sleep Bruxism (SB) and…
- Conditions
- Myofascial Temporomandibular Disorder, Bruxism, Sleep, Sleep Disturbance, Jaw Spasm
- Trial name
- NCT04842136
- Testing
- Scales and indexes
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Migraine
"Personalized Physiotherapy for Migraine: Effects on Pain, Fatigue, and Physical Function"
Migraine is a prevalent neurological disorder associated with pain, fatigue, and reduced physical function. The aim of this randomized controlled trial is to examine the effects of a personalized and structured physiotherapy…
- Trial name
- TIP-MIG (NCT07261384)
- Testing
- Personalized Structured Physiotherapy Intervention, Standard Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Acute Migraine
Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack
Patients with acute migraine attack make up the majority of patients consulting the emergency services due to headache. The aim of treatment in the emergency service is to achieve a minimum level of undesirable side effects and…
- Trial name
- NCT01730326
- Testing
- Paracetamol, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Migraine
A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults
PF-05180999 is a phosphodiesterase-2 inhibitor that is hypothesized to be able to reduce vascular permeability. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and effects on histamine-induced…
- Trial name
- NCT01981499
- Testing
- PF-05180999, 120 mg MR PF-05180999, 360 mg MR PF-05180999
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pfizer
Headache, Migraine
Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP
Aims: To investigate the efficacy of laser-acupuncture for the severity of primary headache and comorbidities, and the Lab data examination.
- Trial name
- NCT06584409
- Testing
- Laser Pen, Observation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Headache
Equity in Diagnostic Imaging Trial
This study will 1) Develop two interventions: a) an audit-feedback email intervention that provides clinicians with data on CT scan ordering practices by patient race; and b) a clinical decision support (CDS) message in the…
- Trial name
- EDIT (NCT01611714)
- Testing
- Audit-feedback, Clinical Decision Support
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
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