Clinical trials: Cephalalgia
Migraine
Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
Opioids are commonly used to treat migraine in North American Emergency Departments. We are comparing efficacy and adverse events of hydromorphone, an opioid, to that of prochlorperazine, a dopamine antagonist with known efficacy…
- Trial name
- NCT02389829
- Testing
- Hydromorphone, Prochlorperazine, Diphenhydramine
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Montefiore Medical Center
Faceto-genic Neck Pain, Shoulder Pain Chronic
Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain
Different studies have revealed different success rates and patient satisfaction after cervical facet C-RF. In a study on 32 patients, with 15 months follow up, 25% had complete pain relief (8).
- Conditions
- Faceto-genic Neck Pain, Shoulder Pain Chronic, Faceto-genic Headache
- Trial name
- NCT04124445
- Testing
- Pulsed Radiofrequency Ablation
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Allevio Pain Management Clinic
Idiopathic Intracranial Hypertension
Surgical Idiopathic Intracranial Hypertension Treatment Trial
Randomized trial of adults (≥18 years old) with idiopathic intracranial hypertension and moderate to severe visual loss without substantial recent treatment who are randomly assigned to (1) medical therapy, (2) medical therapy…
- Trial name
- SIGHT (NCT03501966)
- Testing
- Acetazolamide, Optic Nerve Sheath Fenestration, Ventriculoperitoneal CSF Shunting
- Where
- 36 sites in United States, Canada and 1 more
- Volunteers
- 7 people
- Sponsor
- Jaeb Center for Health Research
Theophylline, Sumatriptan
Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache
The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.
- Conditions
- Theophylline, Sumatriptan, Gabapentin, Post-Dural Puncture Headache
- Trial name
- NCT07515456
- Testing
- Theophylline, Sumatriptan, Gabapentin
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Dysmenorrhea, Menstrual Cramps
A Single Group Study to Evaluate the Effects of a Topical Product on Cramps Associated With the Menstrual Cycle
This study evaluates the effectiveness of a topical product in reducing discomfort associated with menstrual cramps and back pain.
- Trial name
- NCT06939972
- Testing
- Topical Analgesic with Camphor and Menthol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rael
Cervicogenic Headache
Osteopathic Care Combined With Physiotherapy and Pain Education for Cervicogenic Headache
Introduction: Cervicogenic headache (CH) is a secondary headache associated with non-traumatic dysfunctions of the cervical region.
- Trial name
- NCT07794319
- Testing
- Osteopathic Care, Physiotherapy
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Centro Universitário Augusto Motta
Chronic Cluster Headache
Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache
Cluster headache is a primary headache that chiefly affects young men, and is less common than migraine. This disease can have devastating consequences due to the pain intensity (it is also called "suicide headache"), to the side…
- Trial name
- ANODECCH (NCT02462395)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- University of Liege
Headache
Acupuncture - a Treatment for Children With Headache
Acupuncture as a treatment for headache in children
- Trial name
- NCT03426800
- Testing
- Acupuncture and training
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Regionshospital Nordjylland
Migraine Disorders
Reliability of Rimegepant or Triptans for the Acute Treatment of Migraine
This protocol describes the analysis of the Adelphi Real World (ARW) Migraine Disease Specific Programme(TM) 2022, a cross-sectional study which used both physician and patient surveys to assess the perception of the acute…
- Trial name
- Adelphi DSP (NCT06412965)
- Where
- United States
- Volunteers
- 528 people
- Sponsor
- Pfizer
Chronic Headache
Project CHEER (Comprehensive Headache Evaluation, Education, Relief)
PROJECT CHEER is a randomized controlled trial designed to test the effectiveness of a comprehensive focused approach to headache care.
- Trial name
- NCT00417742
- Testing
- Service delivery through a Headache Management Program
- Where
- 3 sites in United States
- Volunteers
- 828 people
- Sponsor
- Duke University
Cluster Headache
Atrioventricular Block and Cluster Headache (SEVA)
Verapamil is a calcium channel blocker widely used to treat cardiovascular diseases however it is also the first line treatment in the prevention of cluster headaches.
- Trial name
- SEVA (NCT04406259)
- Testing
- Verapamil
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Migraine Disorders, Obesity
A Pilot Study of Migraine and Appetite Behaviour in Children
The purpose of this study is to determine whether there is an association between migraine in children and certain patterns of appetite or eating behaviour that may lead to later obesity.
- Trial name
- NCT00930852
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Chronic Migraine
Treximet in the Treatment of Chronic Migraine
This study is being conducted to evaluate the hypothesis that use of Treximet in patients with chronic migraine, when used on a short term daily basis and as rescue for break through attacks, will reduce migraine frequency and…
- Trial name
- NCT01090050
- Testing
- Sumatriptan/Naproxen Sodium, Naproxen Sodium
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Cady, Roger, M.D.
Migraine
Clinical Effectiveness of Osteopathic Manipulative Treatment in Chronic Migraine
The aim of the present study is to determine the extend to which OMT is effective on a sample of subjects affected by migraine evaluated using the headache impact test (HIT-6) questionnaire.
- Trial name
- NCT01851148
- Testing
- osteopathic manipulative treatment, triptans
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Pain, Head Pain
Aromatherapy Massage in Migraine Attacks
The aim of the study was to determine the effect of aromatherapy massage on the pain severity and quality of life in patients diagnosed with migraine in addition to medical treatment during an acute migraine attack.
- Conditions
- Pain, Head Pain, Quality of Life
- Trial name
- NCT04151576
- Testing
- aromatherapy massage
- Volunteers
- 83 people
- Sponsor
- Biruni University
Chronic Headaches
Bion for Occipital Nerve Stimulation
This is a prospective, single-centre, cross-over study designed to evaluate the safety and efficacy of using the bion, an implantable medical device, for the treatment of chronic headaches.
- Trial name
- NCT00205829
- Testing
- battery-powered bion(R) microstimulator system
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Chronic Migraine, Medication Overuse Headache
Mindfulness Therapy for Chronic Migraine
The aim is to assess the efficacy of adding on a Mindfulness-based therapy to pharmacological prophylaxis (experimental group: pharmacological prophylaxis + Mindfulness) against pharmacological prophylaxis only (control group) on…
- Trial name
- Mind-CM (NCT03671681)
- Testing
- Mindfulness, Prophylactic
- Where
- Italy
- Volunteers
- 177 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Cluster Headache
Efficacy and Safety of Zolmitriptan by Sublingual Administration
The purpose is to evaluate the effectiveness and safety profile of zolmitriptan by Sublingual administration for the acute treatment of Cluster headache.
- Trial name
- NCT03377257
- Testing
- zolmitriptan by sublingual administration, zolmitriptan by oral
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Migraine
Migraine Treatment Satisfaction With Treximet Versus Concomitant 2 Aleve and Imitrex
This is an open label, 6 month cross over study in 50 migraine patients fulfilling International Headache Society Classification criteria for migraine headache with and without aura having 2-6 migraines per month and not over 14…
- Trial name
- NCT01450995
- Testing
- Treximet, Imitrex and two Aleve
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stephen H. Landy, M.D.
Acute Migraine
Long-term Safety Study of BHV-3500 (Zavegepant*) for the Acute Treatment of Migraine
The purpose of this study is to evaluate the long-term safety of BHV-3500/vazegepant intranasal in the acute treatment of migraine. BHV-3500, formerly "vazegepant", is now referred to as "zavegepant" (za ve' je pant).
- Trial name
- NCT04408794
- Testing
- Zavegepant (BHV-3500)
- Where
- 67 sites in United States
- Volunteers
- 974 people
- Sponsor
- Pfizer
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