Clinical trials: Cerebellar Diseases
Brain and Central Nervous System Tumors, Leukemia
Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial
RATIONALE: Gathering information about why patients or their guardians agree or decline to participate in the optional pharmacokinetic portion of a phase I treatment study may help doctors plan clinical trials in the future.
- Conditions
- Brain and Central Nervous System Tumors, Leukemia, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00890435
- Testing
- questionnaire administration, psychosocial assessment and care
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Brain and Central Nervous System Tumors, Neuroblastoma
Docetaxel in Treating Children With Recurrent Solid Tumors
Phase II trial to study the effectiveness of docetaxel in treating children with recurrent solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Brain and Central Nervous System Tumors, Neuroblastoma, Sarcoma
- Trial name
- NCT00002825
- Testing
- filgrastim, docetaxel
- Where
- 36 sites in United States, Australia and 1 more
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Progressive Supranuclear Palsy, Fall
Cerebellar rTMS Theta Burst for Postural Instability in Progressive Supranuclear Palsy
Objective of the study: To test the efficacy of theta burst cerebellar stimulation on postural instability in progressive supranuclear palsy using a cross-over design and wearing sensors technology Design: Twenty probable PSP…
- Conditions
- Progressive Supranuclear Palsy, Fall, Gait, Rigid, Parkinsonism
- Trial name
- CerTI-PSP (NCT04222218)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Europea di Ricerca Biomedica Ferb Onlus
Deglutition Disorders, Ischemic Stroke
Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia
The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke.
- Trial name
- DENTIS-PSD (NCT07766668)
- Testing
- Active Transcranial Temporal Interference Stimulation, Standardized Task-Specific Swallowing Rehabilitation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhejiang University
Ataxia, Cerebellar, Cerebellar Ataxia
Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia
Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been…
- Conditions
- Ataxia, Cerebellar, Cerebellar Ataxia, Spinocerebellar Ataxias, Ataxia, Spinocerebellar
- Trial name
- CStDCSAtaxia (NCT03120013)
- Testing
- Anodal cerebellar and cathodal spinal tDCS
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Autism Spectrum Disorder, Theta Burst Stimulation
Explore the Impacts of One Session and Multiple Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder
This study aims to establish a personalized theta burst stimulation (TBS, an advanced variant of repetitive transcranial magnetic stimulation, rTMS) protocol considering autistic idiosyncrasy (interindividual variability).
- Trial name
- NCT07114770
- Testing
- Theta Burst Stimulation (TBS, an advanced variant of repetitive transcranial magnetic stimulation)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Machado-Joseph Disease / Spinocerebellar Ataxia 3
Study To Assess Safety, Tolerability and Efficacy of Intravenous Cabaletta in Patients With Machado-Joseph Disease
This is an exploratory, randomized, parallel-group, dose escalation and dose-controlled study without a placebo arm. Eligible patients will be randomized in a 1:1 ratio (double-blind) to receive Cabaletta in 2 doses, once weekly…
- Trial name
- NCT02147886
- Testing
- Cabaletta for IV infusion once weekly during 24 weeks
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Bioblast Pharma Ltd.
Cerebellar Ataxia, Spinocerebellar Ataxias
Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia
The aim of the research is to improve motor function in people with cerebellar ataxia by using neuroimaging methods and mental imagery to "exercise" motor networks in the brain.
- Conditions
- Cerebellar Ataxia, Spinocerebellar Ataxias, Cerebellar Degeneration
- Trial name
- NCT05436262
- Testing
- Real-time fMRI with neurofeedback of motor imagery
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University
Stroke
Multi-session Anodal Cerebellar Transcranial Direct Current Stimulation (tDCS) vs Anodal Cerebral tDCS
To investigate which one of the two cerebellar and cerebral stimulation in comparison to sham stimulation is more effective in enhancing balance and postural stability in stroke patients
- Trial name
- NCT06525129
- Testing
- Cerebellar stimulation group (CbSG), Cerebral (M1) Stimulation group (MSG)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Colorectal Neoplasms
Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC) (MK-7690-046)
This trial will evaluate the safety and efficacy of vicriviroc (MK-7690) at 2 dose levels in combination with pembrolizumab (MK-3475) in participants with advanced/metastatic microsatellite stable (MSS) colorectal cancer (CRC).
- Trial name
- NCT03631407
- Testing
- Vicriviroc, Pembrolizumab
- Where
- 8 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- Merck Sharp & Dohme LLC
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Healthy
Use of Real-Time Functional Magnetic Resonance Imaging Neurofeedback to Improve Motor Function in Cerebellar Ataxia
This project will study the feasibility of motor rehabilitation in people with cerebellar ataxia using real-time functional magnetic resonance imaging neurofeedback (rt-fMRI NF) in conjunction with motor imagery.
- Trial name
- fMRI (NCT05436249)
- Testing
- Neurofeedback treatment, At-home therapy
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Ataxia, Spino Cerebellar Degeneration
Aerobic Exercise, Balance Training, and Ataxia
The first aim is to show aerobic training improves degenerative cerebellar patients functionally The second aim is to compare the effects of balance and aerobic training on degenerative cerebellar disease.
- Conditions
- Ataxia, Spino Cerebellar Degeneration, Spinocerebellar Ataxias
- Trial name
- NCT03745248
- Testing
- Aerobic training, Balance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Ataxia, Gait
Ataxia GAA-FGF14 - Descriptive Genetic and Clinical Study
Cerebellar ataxias of late onset are of undetermined etiology in many cases. A new cause of late-onset cerebellar ataxia was discovered in January 2023 corresponding to an expansion of GAA triplets in intron 1 of the FGF14 gene.
- Trial name
- GAA-FGF14 (NCT05884086)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Stroke, Transcranial Direct Current Stimulation
Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects
Upper extremity motor impairment is one of the major sequelae of stroke, resulting in limitation of activities of daily livings.
- Conditions
- Stroke, Transcranial Direct Current Stimulation, Functional Near Infrared Spectroscopy
- Trial name
- NCT04101695
- Testing
- tDCS
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Multiple System Atrophy
Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
The main objective of the study is to compare the score to the Behavioral Dysexecutive Syndrome Inventory (BDSI) between Parkinsonian Multiple system Atrophy MSA-P patients and cerebellar Multiple System Atrophy (MSA-C) patients…
- Trial name
- CogAMS (NCT02185677)
- Testing
- Clinical evaluation, neuropsychological battery test, MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis, Optic Neuritis
Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis
The current study is a continuation of the 5 year extension study of the phase III CHAMPS study (see reference). This study was designed to determine if immediate initiation of therapy with Interferon Beta-1a (AVONEX) after a…
- Conditions
- Multiple Sclerosis, Optic Neuritis, Transverse Myelitis, Acute Brainstem/Cerebellar Syndrome
- Trial name
- CHAMPIONS10 (NCT00179478)
- Testing
- interferon beta 1a 30 ug IM once weekly
- Where
- 26 sites in United States, Canada
- Volunteers
- 155 people
- Sponsor
- Beth Israel Deaconess Medical Center
Disorder of Consciousness, Vegetative State
Cerebellar iTBS in Patients With Disorders of Consciousness
Previous studies showed the excitatory effect of cerebellar transcranial magnetic stimulation(TMS) on motor cortex.Investigator evaluate the effects of bilateral cerebellar TMS on Coma Recovery Scale-Revised (CRS-R) scores in…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- CTPDOC (NCT05558930)
- Testing
- iTBS stimulation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
Neuropathy, Cerebellar Ataxia
Evaluation of the Peripheral Nerve Ultrasound as a Diagnostic Tool in CANVAS Neuropathies
Cerebellar ataxia with neuropathy and bilateral areflexia syndrome (CANVAS) is a late onset neurodegenerative disorder with a slowly progressive ataxia.
- Conditions
- Neuropathy, Cerebellar Ataxia, Neurodegenerative Diseases
- Trial name
- CANVAS (NCT05095870)
- Testing
- No intervention
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spinocerebellar Ataxia
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)
Background: Spinocerebellar ataxia type 7 (SCA7) is a disease in which people have problems with coordination, balance, speech and vision. It is caused by a change in the ATXN7 gene.
- Trial name
- NCT02741440
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Eye Institute (NEI)