Clinical trials: Cerebral Artery Occlusion
Acute Ischemic Stroke From Large Vessel Occlusion
Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy
This is a prospective, single-arm, open-label study to evaluate the efficacy of intra-arterial tenecteplase in improving microvascular reperfusion following successful large vessel recanalization.
- Trial name
- INTIMA-MT (NCT06904911)
- Testing
- intra-arterial tenecteplase administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Nasopharyngeal Carcinoma, Radiation Therapy Complication
Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
Patients with head and neck cancer who underwent irradiation have a higher risk of developing severe carotid stenosis, and eventually develop to transient ischemic attack or stroke.
- Trial name
- NCT02022293
- Testing
- Atorvastatin
- Where
- 6 sites in China
- Volunteers
- 324 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Carotid Artery Stenosis, Carotid Artery Diseases
Study on the Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets for Cerebral Protection During Carotid Angioplasty
- Trial name
- NCT06959628
- Testing
- Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
Carotid Stenosis, Carotid Artery Plaque
Evaluation of Cerebrovascular Events in Patients With Occlusive Carotid Artery Disorders
As of today, no suitable multiparametric predictive method is available to properly estimate stroke risk in patients with carotid artery stenosis.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Cerebrovascular Embolism and Thrombosis
- Trial name
- NCT03840265
- Testing
- carotid endarterectomy
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Acute Ischemic Stroke
Heparin for RAO Post-Transradial Angiography in AIS
Cerebral angiography is a critical diagnostic tool in neurology, serving as the "gold standard" for evaluating cerebrovascular stenosis, hemodynamics, aneurysms, and arteriovenous malformations.
- Trial name
- NCT07162064
- Testing
- Heparin - Therapeutic dosage, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Xiang Luo
Alzheimer's Disease, Lewy Body Dementia
Pulsed Electromagnetic Field Treatment With Dementia Patients
An open label pilot study in mild to moderate AD/ADRD patients to assess the effects of treatment with ECHS AD/ADRD pulsed electromagnetic treatment device on disease progression. Enrolled patients will receive active devices.
- Conditions
- Alzheimer's Disease, Lewy Body Dementia, Vascular Dementia
- Trial name
- NCT06862557
- Testing
- ECHS AD Device
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Herrick Medical LLC
Stroke, Dementia
Neuro-Prävention im Rahmen Des Interventionsprojektes INVADE-2 (Follow-up Studie)
"Silent" strokes are more frequent than clinical apparent strokes and can be detected noninvasively by MRI-investigations of the brain.
- Trial name
- NCT01126775
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- INVADE gGmbH
Carotid Artery Occlusion
Effectiveness of Surgical and Diagnostic Methods in Cerebral Vascular Occlusive Disease
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data.
- Trial name
- NCT07396025
- Testing
- Revascularization/Conservative management
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan
Atherosclerosis, Cardiovascular Disease
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.
- Conditions
- Atherosclerosis, Cardiovascular Disease, Hypercholesterolemia
- Trial name
- HEART-3 (NCT07839936)
- Testing
- VERVE-102
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Verve Therapeutics, Inc.
Stroke, Ischemic, Stroke Hemorrhagic
Prediction Model for Chronic Intracranial Arterial Occlusion With Radiomic Features
Chronic intracranial arterial occlusion is associated with a "bidirectional stroke risk," with a significantly increased risk of both ischemic stroke and cerebral hemorrhage.
- Trial name
- NCT06066593
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Hospital
Moyamoya Disease
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD).
- Trial name
- BLOSSOM (NCT06634004)
- Testing
- BOLD MRI
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cardiovascular Diseases, Heart Diseases
Adipose Distribution and Atherosclerosis
To relate distribution of adipose tissue measured by a then new imaging technique, Magnetic Resonance Imaging (MRI) to extracranial carotid atherosclerosis, cardiovascular disease risk factors, and to more conventional measures…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Stenosis
- Trial name
- NCT00005348
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Stenosis
Pre-operative Antihypertension Strategies-Carotid Artery Stenting
Carotid artery stenting (CAS) is one of major treatments in prevention of ischemic stroke. Because of sinus reflex due to stenting and balloon dilatation, persistent post-surgery hypotension is a common perioperative event.
- Trial name
- PASS-CAS (NCT05905848)
- Testing
- administering RASI (the trade name or universal name will not be stipulated) before stenting, administering CCB (the trade name or universal name will not be stipulated) before stenting
- Where
- China
- Volunteers
- 560 people
- Sponsor
- West China Hospital
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Moyamoya Disease, Intracranial Atherosclerotic Stroke
Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke.
- Conditions
- Moyamoya Disease, Intracranial Atherosclerotic Stroke, Intracranial Steno-occlusive Disease
- Trial name
- NCT02074111
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Internal Carotid Artery Stenosis
EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy
A highly desired result during carotid endarterectomy (CEA) is the ability to predict and warn the surgeon if the brain is at risk of damage during the period of time that the carotid artery is cross-clamped for surgical repair…
- Trial name
- NCT00737334
- Testing
- EEGo, BIS, FORE-SIGHT cerebral oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Carotid Artery Stenosis
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid…
- Trial name
- CAROTEP (NCT03353103)
- Testing
- Sodium fluoride F-18 PET imaging
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Cognitive Function, Stenosis
Clinical Registration Study of Patients With Intracranial / Carotid Stenosis
Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images.
- Trial name
- NCT05322824
- Testing
- standard medical treatment, Interventional stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Coronary Artery Disease
Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass…
- Conditions
- Stroke, Coronary Artery Disease, Arrhythmia
- Trial name
- NCT00247533
- Testing
- Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
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