Clinical trials: Cerebral Atherosclerosis
Atherosclerosis, Cardiovascular Diseases
Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study
To evaluate the relation of retinal microvascular characteristics to subclinical cardiovascular disease, clinical disease, and their risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- MESA-Eye (NCT00041444)
- Volunteers
- 6,176 people
- Sponsor
- University of Wisconsin, Madison
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Intracranial Arteriosclerosis, Collateral Circulation
Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis
The purpose of this study is to determine whether Urinary Kallikrein has an additional effect on enhancing collateral circulation in symptomatic intracranial atherosclerotic patients under clopidogrel and aspirin dual…
- Conditions
- Intracranial Arteriosclerosis, Collateral Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- NCT04325932
- Testing
- Urinary Kallikrein
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carotid Stenosis, Carotid Artery Diseases
Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
About 20% of strokes are caused by emboli deriving from a carotid plaque. In symptomatic patients with carotid stenosis grater than 70% the Carotid Endarterectomy (CEA) reduces stroke risk by about 75% and is generally accepted…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT05134493
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Carotid Stenosis, Cardiovascular Disease
Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization
The combination of aspirin and dipyridamole, two antiplatelet drugs, is approved in Italy for the secondary prevention of cerebral embolism in patients with carotid atherosclerosis.
- Conditions
- Carotid Stenosis, Cardiovascular Disease, Atherosclerosis, Stroke
- Trial name
- ICAR (NCT02630862)
- Testing
- Aspirin, aspirin plus dipyridamole
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- University of Roma La Sapienza
Heart Diseases
Identifying Genes That May Increase the Risk for Heart Disease in African Americans
Heart disease and stroke disproportionately affect African Americans in the United States. These conditions are likely caused by both environmental and genetic factors.
- Trial name
- NCT00344136
- Where
- United States
- Volunteers
- 5,302 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Artery Plaque
99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
This was a single-center, single-dose, study comprising a Proof of Concept (PoC) part and a subsequent Phase II part. The study was being done to assess the ability of the radiotracer 99mTc-rhAnnexin V-128 to image…
- Trial name
- NCT02667457
- Testing
- 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Advanced Accelerator Applications
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Ischemic Heart Disease, Congestive Heart Failure
Registry of Cardiovascular Disease Patients
A computerized registry of cardiovascular disease patients in a large health maintenance organization in Israel. The registry is aimed to be used by health professionals to identify cardiovascular disease patients and to follow…
- Conditions
- Ischemic Heart Disease, Congestive Heart Failure, Peripheral Vascular Disease, Cerebrovascular Disease
- Trial name
- CVD Registry (NCT01759225)
- Where
- Israel
- Volunteers
- 110,000 people
- Sponsor
- Maccabi Healthcare Services, Israel
Acute Stroke, Ischemic Stroke
Rescue Intracranial Stenting in Acute Ischemic Stroke
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy.
- Conditions
- Acute Stroke, Ischemic Stroke, Intracranial Atherosclerosis, Stent Stenosis
- Trial name
- RISIS (NCT04986774)
- Testing
- Rescue intracranial stenting
- Where
- Vietnam
- Volunteers
- 85 people
- Sponsor
- Can Tho Stroke International Services Hospital
Solid Malignancy Located in the Head and Neck, Cancer
Study of 68GaNOTA-Anti-MMR-VHH2 in Oncological Lesions, Cardiovascular Atherosclerosis, Syndrome With Abnormal Immune Activation and sarcoïdosis
Phase II study to evaluate the clinical potential of 68GaNOTA-anti-MMR-VHH2 for in vivo imaging of Macrophage Mannose Receptor (MMR)-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with…
- Conditions
- Solid Malignancy Located in the Head and Neck, Cancer, Carotid Stenosis, Atherosclerosis of Artery
- Trial name
- MITRAS (NCT04758650)
- Testing
- 68GaNOTA-Anti-MMR-VHH2
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitair Ziekenhuis Brussel
Atherosclerosis
18F-Flutemetamol and Plaque Vulnerability
Rationale: Amyloid beta (Ab) is mainly known for its role in Alzheimer's disease (AD) pathology. However, Ab seems not only to be involved in AD pathology, but also in atherosclerosis, which might explain the remarkable…
- Trial name
- NCT03291093
- Testing
- 18F-Flutemetamol PET/MRI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Hyperlipoproteinemia(a), Progressive Cardiovascular Disease
Randomized Controlled Trial of Lipid Apheresis in Patients With Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease. Non-medical treatment measures (e.g. dietary therapy or weight loss) can hardly influence Lp(a) plasma concentrations.
- Trial name
- ELAILa (NCT01064934)
- Testing
- Lipid apheresis, Standard care
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Ischemic Stroke, Atheroscleroses, Cerebral
Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
- Trial name
- NCT03291652
- Testing
- DSA/3DRA
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Hyperlipidemias, Atherosclerosis
Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy.
- Conditions
- Hyperlipidemias, Atherosclerosis, Coronary Heart Disease, Carotid Stenosis
- Trial name
- NCT00536965
- Where
- Austria
- Volunteers
- 951 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus, Carotid Atherosclerosis
Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes
To investigate the effect of cilostazol compared with aspirin on carotid atherosclerosis in patients with type 2 diabetes mellitus
- Trial name
- NCT03248401
- Testing
- Cilostazol, Aspirin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Familial Hypercholesterolemia, Hypercholesterolemia
Evaluation of a Digiphysical Screening Method to Identify and Diagnose Familial Hypercholesterolemia
Longitudinal and observational registry-based cohort study of individuals participating in the national digiphysical screening program for Familial Hypercholesterolemia.
- Trial name
- DigiLipids (NCT04929457)
- Where
- Sweden
- Volunteers
- 30,000 people
- Sponsor
- Karolinska Institutet
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Vascular Inflammation & Atherosclerosis
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00087893
- Volunteers
- 931 people
- Sponsor
- University of Vermont
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA
Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease: A Randomized Controlled Trial
To compare the efficacy of fixed-dose versus treat-to-target statin regimens in achieving the predefined LDL-C target at 12 weeks in patients with established ASCVD.
- Conditions
- Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA, Cardio Vascular Disease
- Trial name
- NCT07909915
- Testing
- Dose adjustment of statins, no dose adjustment
- Where
- Pakistan
- Volunteers
- 178 people
- Sponsor
- Rehman Medical Institute - RMI