Clinical trials: Cerebral Blood Flow
Physical Activity, Aging
Independent Walking for Brain Health
Physical activity interventions with older adults can improve brain health; however most interventions have been performed in gym-like settings that reach a small sector of the senior population.
- Trial name
- NCT03058146
- Testing
- Mobile Health Walking Condition, Healthy Aging Education Condition
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Cerebral Blood Flow, Brain Function
Effects of Acetate and Alcohol on Brain Function
This study plans to learn more about how alcohol and its metabolite, acetate, affect the brain.
- Trial name
- NCT02542150
- Testing
- acetate, alcohol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post-Resuscitation Syndrome, Critical Illness
Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest.
- Conditions
- Post-Resuscitation Syndrome, Critical Illness, Cardiac Arrest, Hypoxic-Ischemic Encephalopathy
- Trial name
- PROM-ROSC (NCT07020091)
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Ahmet Düzgün
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Ischemic Stroke
Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization
The primary objective of this Phase 2 HASTIER study, as an ancillary study to ICTuS 2, is to compare key imaging measurements for serial changes in recanalization and reperfusion between hypothermia and normothermia treatment…
- Trial name
- HASTIER (NCT01778855)
- Testing
- IV t-PA and normothermia, IV-tPA and hypothermia
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Alzheimer Disease
Stimulating Neural Activity to Improve Blood Flow and Reduce Amyloid: Path to Clinical Trials
Alzheimer's disease is characterized by the accumulation of toxic proteins in the brain. Mechanisms to remove these proteins have been the target of many drug trials.
- Trial name
- FLICKER (NCT03543878)
- Testing
- Flicker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Stroke
Visualization of Cerebral Arteries Using Contrast-Enhanced Transcranial Ultrasound in Stroke Patients
The purpose of this study is to find out more about the usefulness of ultrasound in combination with a contrast solution to look for blood vessel blockage or occlusion in the brains of stroke patients.
- Trial name
- NCT00282841
- Testing
- ultrasound
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of California, San Diego
Ischemic Stroke
Glyburide Advantage in Malignant Edema and Stroke Pilot
The primary objective of this study is to assess the feasibility of enrolling, evaluating, and treating with glyburide for injection severe anterior circulation ischemic stroke participants, whether or not treated with standard…
- Trial name
- GAMES-PILOT (NCT01268683)
- Testing
- Glyburide for Injection
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Vertebrobasilar Insufficiency, Ischemic Attack, Transient
Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS)
Patients with blockage of the blood vessels that supply blood to the back of the brain, known as vertebrobasilar disease (VBD), are at risk of having a stroke or temporary symptoms of a stroke known as transient ischemic attack…
- Conditions
- Vertebrobasilar Insufficiency, Ischemic Attack, Transient, Cerebrovascular Disorder, Brain Ischemia
- Trial name
- VERiTAS (NCT00590980)
- Where
- 6 sites in United States, Canada
- Volunteers
- 82 people
- Sponsor
- University of Illinois at Chicago
Cognitive Function, Mood
Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large amount of research indicates EGCG (amongst other…
- Trial name
- NCT00981292
- Testing
- EGCG
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive and Cerebral Blood Flow Effects of Resveratrol
The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO).
- Trial name
- NCT01010009
- Testing
- Trans- resveratrol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dementia, Alzheimer Disease
The Cognition and Flow Study
About the research There are currently 850,000 people living with dementia in the United Kingdom. It is now understand that Alzheimer's disease (AzD) can result from damaged blood vessels in the brain.
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Aging
- Trial name
- NCT03656107
- Testing
- Cognitive Training
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neurogenic Orthostatic Hypotension, Autonomic Failure
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
The purpose of this study is to learn more about the effects of abdominal compression and the medication midodrine, two interventions used for the treatment of orthostatic hypotension (low blood pressure on standing), on…
- Conditions
- Neurogenic Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT04620382
- Testing
- Midodrine, Abdominal compression
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Cerebral Ischemia
Desflurane Versus Propofol in the Sitting Position
The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.
- Trial name
- NCT01436799
- Testing
- propofol, Desflurane, alfentanil
- Volunteers
- 40 people
- Sponsor
- Gachon University Gil Medical Center
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetes
UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation
Cerebral autoregulation (CA) is a complex mechanism that serves the essential and vital purpose of controlling cerebral blood flow and metabolism. A stable and optimal brain blood flow is imperative for normal brain function.
- Trial name
- UTLight (NCT02178787)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Stroke, Acute
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM (NCT01585597)
- Testing
- Zoll- Coolgaurd 3000
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University