Clinical trials: Cerebral Circulatory Disorder
Ischemic Stroke
Clinical Trial of Umbilical Cord Mesenchymal Stem Cells in Subacute Ischemic Stroke
The goal of this clinical trial is to evaluate the efficacy, safety, and pharmacodynamic characteristics of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) in adults with ischemic stroke in the anterior circulation during…
- Trial name
- NCT07197606
- Testing
- IxCell hUC-MSC-S (Human Umbilical Cord Mesenchymal Stem Cells)
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shanghai IxCell Biotechnology Co., LTD
Refractory Epilepsy, Arrhythmia
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population, accounting for 10-50% of deaths for…
- Conditions
- Refractory Epilepsy, Arrhythmia, Sudden Death
- Trial name
- NCT00203333
- Testing
- Medtronic REVEAL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Cerebral Arteriovenous Malformation
Lovastatin for Treatment of Brain Arteriovenous Malformations
The purpose of this pilot study is to evaluate the disease-modifying efficacy of lovastatin in patients with brain arteriovenous malformation.
- Trial name
- NCT04297033
- Testing
- Lovastatin
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Stenosis
Gadobutrol Enhanced MRA of the Supra-aortic Vessels
Subjects referred for a routine CTA (computed tomography angiography) or MRA (magnetic resonance angiography) will be invited to participate in the study and subjects will be involved in the study for between 2 and 12 days.
- Trial name
- GEMSAV (NCT01344447)
- Testing
- Gadobutrol (Gadovist, BAY86-4875)
- Where
- 56 sites in United States, Argentina and 12 more
- Volunteers
- 479 people
- Sponsor
- Bayer
Carotid Artery Diseases
Digital Variance Angiography for Contrast Media Dose Reduction in Carotid Artery Stenting
Digital Variance Angiography (DVA) is a new tool in medical imaging with a proven image quality reserve (1, 2). Previous studies have demonstrated the quality reserve of DVA in angiographic studies (1, 2), which allowed us to…
- Trial name
- NCT04792255
- Testing
- Carotid artery stenting with standard contrast media protocol, Carotid artery stenting with reduced contrast media protocol, Carotid Duplex Ultrasound
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Kinepict Health Ltd.
Brain Ischemia, Hemiplegic Patients With Stroke
Using fMRI and sEMG to Evaluate the Effects and Mechanism on Abdominal Acupuncture Combined With Upper Limb Rehabilitation Training on Brain Plasticity of Hemiplegic Patients With Stroke
Using random number method to categorize the selected first onset patients with stroke who meet the inclusion criteria into 3 groups.The patients were randomly divided into treatment group A(abdominal acupuncture+upper limb…
- Conditions
- Brain Ischemia, Hemiplegic Patients With Stroke, Image Science, Electrophysiology of Neuromuscular
- Trial name
- NCT03712085
- Testing
- Abdominal acupuncture
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 66 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Middle Cerebral Artery Aneurysm
Risk Factors of Middle Cerebral Artery Aneurysm.
According to the current view, cerebral aneurysms are acquired degenerative lesions resulting from hemodynamic stress. This single-center case-control study will be carried out at the Department of Neurosurgery, Regional Hospital…
- Trial name
- MCAA (NCT03493035)
- Testing
- Computed tomography angiography (3D CTA), Transcranial color-coded sonography (TCCS)
- Where
- Poland
- Volunteers
- 190 people
- Sponsor
- Medical University of Silesia
Atrial Fibrillation, Stroke, Ischemic
Echocardiographic Predictors of Atrial Fibrillation
This prospective study aims to identify the diagnostic accuracy of echocardiographic predictors of atrial fibrillation in patients with ESUS (embolic stroke of undetermined source) or TIA (transient ischemic attack).
- Conditions
- Atrial Fibrillation, Stroke, Ischemic, Embolic Stroke of Undetermined Source, TIA, Brain
- Trial name
- EPAF-7 (NCT05044208)
- Testing
- ECG monitoring
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Stroke, Stroke, Acute
Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke
The primary objective of this study is to determine the efficacy of a single intravenous infusion of unrelated donor umbilical cord blood (UCB) for improving functional outcomes in patients with ischemic stroke.
- Conditions
- Stroke, Stroke, Acute, Brain Injury, Acute
- Trial name
- CoBIS 2 (NCT03004976)
- Testing
- Umbilical Cord Blood
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Joanne Kurtzberg, MD
Ischemic Stroke
Speech and Language Therapy After Stroke
Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.
- Trial name
- NCT00713050
- Testing
- Imitate Therapy
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Stroke
Clinical Efficacy of Luna EMG Robot Therapy for Patients After Stroke
A lot of studies prove that rehabilitation with the use of modern devices accelerates the recovery of function in patients after stroke.
- Trial name
- NCT03888118
- Testing
- Luna EMG
- Volunteers
- 60 people
- Sponsor
- Rehamed Center
Intracranial Arteriovenous Malformations (AVM)
Protocol for Staged Stereotactic Radiosurgery for Large Arteriovenous Malformations
Stereotactic radiosurgery is a well established treatment option for arteriovenous malformations (AVMs). The potential complications related to radiosurgery are well documented and are predominately related to radiation effects…
- Trial name
- NCT02576535
- Testing
- Fractionated stereotactic radiosurgery, Leskell gamma unit
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Acute Stroke, Ischemic Stroke, Acute
Tandem Occlusion After Emergent Stenting in Acute Ischemic Stroke
In acute ischemic stroke due to tandem occlusion, the emergent stenting has recently become an endovascular treatment option combining with mechanical thrombectomy to achieve recanalization.
- Trial name
- TOESIS (NCT06120218)
- Testing
- Emergent Stenting
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Can Tho Stroke International Services Hospital
Post Stroke Fatigue, Stroke
How to Identify Fatigue in Stroke Patients
This study will translate an English case definition of poststroke fatigue and validate it against the Multidimensional Fatigue Questionnaire-20 and the Fatigue Severity Scale
- Trial name
- NCT03034590
- Testing
- questionnaire
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Herlev Hospital
Cerebrovascular Accident, Stroke, Acute
Fabry and Cardiomyopathy (FaCard)
Primary objective and endpoint is the analysis of the long-term course of lyso-Gb3 and its clinical correlation to the progression of the cardiomyopathy in N215S-Fabry patients.
- Conditions
- Cerebrovascular Accident, Stroke, Acute, Cerebral Stroke
- Trial name
- FaCard (NCT01429597)
- Where
- Germany
- Sponsor
- CENTOGENE GmbH Rostock
Moyamoya Disease, Ischemic Cerebral Infarction
NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events
An extracranial-to-intracranial (EC-IC) revascularization is the most widely used treatment to improve cerebral perfusion in patients with moyamoya disease (MMD), and it has been shown to reduce the risk of subsequent stroke and…
- Conditions
- Moyamoya Disease, Ischemic Cerebral Infarction, Ischemic Stroke, Ischemic Cerebrovascular Accident
- Trial name
- NICE-MMD (NCT04205578)
- Testing
- dl-3-n-butylphthalide (NBP), Normal Saline 0.9% Infusion Solution
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- yuanli Zhao
Muscle Spasticity, Stroke
OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
This is a safety and efficacy study of onabotulinumtoxinA in poststroke patients with upper limb spasticity.
- Trial name
- NCT02145676
- Testing
- onabotulinumtoxinA
- Where
- 2 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Allergan
Stroke
The Relationship of Trunk Control With Lower Extremity Sense, Balance and Gait in Stroke
Cerebrovascular accident is the third leading cause of death in developed countries after heart disease and cancer. In adults, it ranks first among neurological diseases in terms of causing death and disability.
- Trial name
- NCT05244850
- Testing
- Test
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
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