Clinical trials: Cerebral Circulatory Disorder
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, Stroke
Predictors of Atrial Fibrillation in Patients Undergoing Implantable Loop Recorder Implant
Implantable Loop Recorders (ILR) are small devices the size of a memory stick, which are implanted to investigate stroke, palpitations and fainting episodes.
- Trial name
- NCT04724889
- Testing
- blood test
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Stroke
Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients
This is a pilot randomised controlled trial investigating a combination of unilateral strength training (cross-education) and mirror therapy for the rehabilitation of lower limb impairment following a stroke.
- Trial name
- NCT03497650
- Testing
- Mirror Therapy, Cross-Education of Strengthening.
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- Institute of Technology, Sligo
Stroke, Stroke, Acute
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- TESTED (NCT05911568)
- Testing
- Endovascular Stroke Treatment, Medical Management
- Where
- 35 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- University of Cincinnati
Acute Ischemic Stroke, Tenecteplase
Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging
The benefit of intravenous tenecteplase for acute ischemic stroke with unknown time of onset, e.g. wake-up stroke, remains uncertain.
- Trial name
- UTOPIA (NCT07475949)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment
- Where
- 15 sites in China
- Volunteers
- 352 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy
Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis
Giant cell arteritis (GCA) is an inflammation of the blood vessels. A dangerous complication is sudden vision loss due to insufficient blood supply to the optic nerve.
- Conditions
- Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
- Trial name
- VISION-GCA (NCT07206238)
- Testing
- Positron Emission Tomography / Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction (MI), Stroke
Smartphone Application to PREDICT Real-Time Cardiovascular Risk for Heart Attack and Stroke
To assess the diagnostic accuracy of a smartphone application in predicting heart attack or stroke within 3-4 days in high-risk patients.
- Trial name
- PREDICT-HS (NCT07735338)
- Testing
- Smartphone application Antshrike
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Stroke
Effect of a Community Exercise Programme on Stroke Patients
Physical activity is known to be beneficial for supporting health and wellbeing. A number of schemes and strategies have been developed to improve uptake of physical activity in the United Kingdom (UK) population, including the…
- Trial name
- NCT05320549
- Testing
- Community Programme
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Winchester
Subarachnoid Hemorrhage, Pneumonia, Bacterial
Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI).
- Trial name
- SAH-CIP (NCT05094349)
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Brest
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Stroke
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.
Ischemic stroke (IS) causes high mortality and severe disability. To improve outcome it's very important to choose the right way of the management of the patient and an appropriate drugs.
- Trial name
- 3C (NCT01388738)
- Testing
- citicoline, L-Alpha glycerylphosphorylcholine, cerebrolysin
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Clinical Institute of the Brain, Russia
Oropharyngeal Dysphagia, Stroke
Effect of a Cooling Sensation Flavor on the Swallow Response in Post-stroke Patients With Oropharyngeal Dysphagia
Current oropharyngeal dysphagia (OD) treatment in older patients is based on compensatory strategies (fluid thickening and texture modified diets) that improve swallow safety but do not improve the swallowing function.
- Conditions
- Oropharyngeal Dysphagia, Stroke, Swallowing Disorder
- Trial name
- NCT06250426
- Testing
- Pre-thickened oral nutritional supplement with a cooling sensation flavour, Pre-thickened oral nutritional supplement without a cooling sensation flavour
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital de Mataró
Stroke, Stroke, Acute
Phase 1 Study to Assess AER-271
The objective of this Phase 1 trial is to assess the safety, tolerability and pharmacokinetics of AER-271 in health subjects.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- NCT03804476
- Testing
- AER-271
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aeromics, Inc.
Stroke, Atherosclerosis
Comparison of the Improvement and Safety of the Ankle Brachial Arterial Pressure Index of Sarpogrelate and Clopidogrel in Stroke Patients With Decreased Ankle Brachial Arterial Pressure Index and Intermittent Claudication of Lower Limb Vascular Atherosclerosis.
The clinical trial aims to confirm the improvement effect of the ankle brachial index and the safety of sarpogrelate administration compared to clopidogrel in stroke patients with decreased ankle brachial arterial pressure index…
- Trial name
- NCT06424548
- Testing
- Administration of Sarpogrelate, Traditional administration of Clopidogrel
- Volunteers
- 100 people
- Sponsor
- Ewha Womans University Seoul Hospital
Stroke
Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke
Ischemic stroke has a variety of treatments and currently drug therapy is one of the main treatments.A number of clinical studies have proved that alprostadil (PGE1) has pharmacological effects of significant dilation of blood…
- Trial name
- NCT03252626
- Testing
- Alprostadil, Normal saline
- Volunteers
- 950 people
- Sponsor
- The First Hospital of Jilin University
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation
The objective of the study is to compare the incidence of Hypoxic ischemic encephalopathy (all stages) among singleton term neonates (≥ 37 weeks) requiring resuscitation who will undergo Umbilical cord milking as compared to…
- Trial name
- NCT06090968
- Testing
- Umbilical cord milking, Immediate cord clamping
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Lady Hardinge Medical College
Atrial Fibrillation, Neuropsychology
Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients
In elderly patients with atrial fibrillation (AF) the presence of silent brain infarcts and neurocognitive deficit is high despite adequate treatment with oral anticoagulation.
- Conditions
- Atrial Fibrillation, Neuropsychology, Magnetic Resonance Imaging, Inflammation
- Trial name
- SPACE (NCT00449410)
- Testing
- Atorvastatin, ezetimibe
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Atrial Fibrillation
Atrial Fibrillation (AF) Clinic to Improve the Treatment of Patients With Atrial Fibrillation.
Randomized controlled trial comparing specialized AF Clinic with 'care as usual' Hypothesis: treatment of AF patients in the AF-Clinic by a nurse, specialised in AF, using guideline-based dedicated software, under supervision of…
- Trial name
- AFClinic (NCT00753259)
- Testing
- AF Clinic, Care as Usual
- Where
- 2 sites in Netherlands
- Volunteers
- 712 people
- Sponsor
- Maastricht University Medical Center
Hyperlipidemias, Atherosclerosis
Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy.
- Conditions
- Hyperlipidemias, Atherosclerosis, Coronary Heart Disease, Carotid Stenosis
- Trial name
- NCT00536796
- Where
- Austria
- Volunteers
- 1,096 people
- Sponsor
- AstraZeneca
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