Clinical trials: Cerebral Circulatory Disorder
Aquired Brain Injury, Traumatic Brain Injuries
Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices
Background: Cardiovascular and neurological conditions are major causes of disability worldwide. Early, intensive rehabilitation is essential but often challenging to access in current healthcare systems.
- Conditions
- Aquired Brain Injury, Traumatic Brain Injuries, Stroke, Cardiovascular Diseases
- Trial name
- NCT06867081
- Testing
- The intervention will be the BRILLIANT Platform, an online platform which provides five Modules aimed at increasing coordination of care and direct rehabilitation time
- Where
- 2 sites in Canada
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Ischemic Stroke, TIA
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute…
- Trial name
- NCT05439356
- Testing
- Colchicine
- Where
- 244 sites in China
- Volunteers
- 8,343 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage (SAH)
Serum Procalcitonin
Systemic inflammatory response syndrome (SIRS) is characterized by changes in body temperature, heart rate, respiratory rate, or peripheral blood white cell count, and is often a heralding manifestation of blood infection (ie.…
- Trial name
- NCT00954551
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Drug Resistance, Microbial
Intestinal Microbiota and Antimicrobial Resistance
Antimicrobial resistance is regarded as one of the major global public health threats, causing at least 700,000 deaths per year.
- Trial name
- NCT03794453
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Giant Cell Arteritis
Tocilizumab for Patients With Giant Cell Arteritis
Giant-cell arteritis (GCA) is an immune-mediated disease that mostly affects people older than 50 years of age. Glucocorticoid (GC) treatment dramatically alters the symptoms and course of GCA, reducing the likelihood of vascular…
- Trial name
- NCT01450137
- Testing
- Tocilizumab + Glucocorticoids (GCs)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischemic Stroke
PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke
Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset.
- Trial name
- NCT04571177
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Stroke, Intra Cerebral Hemorrhage
Influence of Cerebral Oedema in Intracerebral Haemorrhage
In 2020, IntraCerebral Haemorraghe (ICH) remains the most devastating type of stroke. Besides stroke unit care, no specific treatment has been proven effective yet.
- Trial name
- COPITCH (NCT04621357)
- Testing
- Brain MRI, Biological biomarkers
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Stroke, Incomplete Spinal Cord Injury
Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations
Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment.
- Conditions
- Stroke, Incomplete Spinal Cord Injury, Traumatic Brain Injury, Acquired Brain Injury
- Trial name
- NCT07237386
- Testing
- Wearing smart insoles
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Stroke, Ischemic Cerebrovascular Accident
Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute Stroke
The goal of this clinical trial is to learn if a device which provides vagal nerve stimulation, applied to the tragus of the ear via an ear clip, can improve sleep in individuals recovering from stroke while they are treated in a…
- Conditions
- Stroke, Ischemic Cerebrovascular Accident, Ischemic Stroke, Vagal Nerve Stimulation
- Trial name
- NCT07858656
- Testing
- transauricular Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Depression, Stroke
Yoga Exercise for Improving Balance in Patients With Subacute &Ｃhronic Stroke
Hypothesis: This study investigated the hypothesis that subacute and chronic stroke patients who received a combination of yoga and traditional physiotherapy were getting more improvement in standing balance than traditional…
- Trial name
- NCT01806922
- Testing
- Yoga
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Stroke, Brain Injuries
The Efficacy of Dynamic Hand Splint Treatment in Spastic Hemiparetic Patients
The purpose of this randomized controlled trial was designed to study the efficacy of dynamic hand splinting on spastic hemiparetic patients due to stroke or traumatic brain injury.
- Trial name
- NCT04441437
- Testing
- Task-oriented training with a dynamic hand splint, Task-oriented training without a dynamic hand splint
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute, Stroke
Treatments for Recovery of Hand Function in Acute Stroke Survivors
Impaired hand function is one of the most frequently persisting consequences of stroke. The purpose of this study is to investigate whether two different types of treatment improve recovery of hand function after stroke.
- Conditions
- Stroke, Acute, Stroke, Hemiparesis, Hemiplegia
- Trial name
- NCT00565045
- Testing
- Neuromuscular electrical stimulator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- MetroHealth Medical Center
Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD)
KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
The KHENERFIN study aims to determine whether the study medicine, sonlicromanol, is able to reduce symptoms of fatigue and the impact of fatigue on daily life, and whether sonlicromanol is able to improve physical abilities of…
- Conditions
- Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS), Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
- Trial name
- KH176-301 (NCT06451757)
- Testing
- Sonlicromanol
- Where
- 10 sites in United States, Denmark and 5 more
- Volunteers
- 220 people
- Sponsor
- Khondrion BV
Stroke
Validation of a French Quality of Life Questionnaire Adapted to Persons Who Have Suffered a Stroke
The aim of this work is to develop and validate a scale adapted to French cultural characteristics. It will be based on the SS-QoL scale and be simple and quick to use in everyday practice. It is not simply a translation.
- Trial name
- QUALI STROKE (NCT02855970)
- Testing
- completion of a quality of life questionnaire
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ischemic Stroke
Decoding Risks and Rewards in Ischemic Stroke Surgery
In the high-stakes battle against ischemic cerebrovascular disease, where every second counts and the margin for error is slim, how do the investigators tip the scales in favor of patient survival and improved outcomes? This…
- Trial name
- NCT06098066
- Where
- Taiwan
- Volunteers
- 204,411 people
- Sponsor
- China Medical University Hospital
Stroke, Acute
Human Urinary Kallidinogenase Improve Short Term Motor Functional Outcome of Acute Ischemia Stroke Patients
Acute cerebral infarction is a common type of ischemic stroke, causing brain dysfunction in patients with high morbidity and disability.
- Trial name
- NCT04102956
- Testing
- Kallikrein
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Hebei Medical University
Subarachnoid Hemorrhage, Hydrocephalus
Strategies for Weaning From External Ventricular Drainage
External ventricular drainage is frequently used in neurocritical care, particularly in patients admitted for non-traumatic subarachnoid hemorrhage who develop hydrocephalus and/or intracranial hypertension.
- Conditions
- Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage
- Trial name
- SEVDVE2 (NCT07630051)
- Testing
- Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Angers
Stroke, Impairment Upper Limb
Therapy to Improve Reaching Movement in Upper Limb
Strokes are caused by a bleed in the brain and can be life threatening. One common consequence is upper limb impairment. This causes stroke patients to be unable to use their arms and upper body to do simple tasks such as…
- Trial name
- NCT03508037
- Testing
- Neuromodulation electroencephalographic signals and functional electrical stimulation based
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Cajal Institute of the Spanish National Research Council
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.