Clinical trials: Cerebral Concussion
Post-Concussion Syndrome
Cerebellar TDCS for SRPCS Treatment
This study is investigating the immediate and long-term effects of bilateral cerebellar transcranial direct current stimulation on cognition, balance, and symptom severity in people with sports-related post-concussion syndrome.
- Trial name
- NCT04760899
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Mild Traumatic Brain Injury, Concussion, Chronic Dizziness
Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms
This study aims to determine whether the delivery of brain stimulation paired with a balance training task can improve symptoms of dizziness for individuals experiencing these symptoms due to concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Chronic Dizziness, Vestibular Problem
- Trial name
- NCT06735157
- Testing
- Repetitive transcranial magnetic stimulation, Augmented reality vestibular rehabilitation therapy
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
TBI (Traumatic Brain Injury), Implementation Research
Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test
The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential…
- Trial name
- EDI (NCT07373509)
- Testing
- i-STAT Alinity TBI test
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Shawn Eagle
Traumatic Brain Injury, Concussion, Mild
Rapid Biochemical Diagnostics of Traumatic Brain Injury
The objective of the study is to confirm the clinical relevance of the novel biomarker for traumatic brain injury (TBI) detection.
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Bone Fracture
- Trial name
- NCT03306563
- Testing
- Sample collection
- Where
- 3 sites in Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Concussion, Mild Traumatic Brain Injury
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
In recent years, media attention has focused on the long-term sequelae of repeated concussive episodes in professional athletes.
- Trial name
- NCT01903525
- Testing
- Docosahexaenoic acid (DHA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
MTBI - Mild Traumatic Brain Injury, Dysfunction of Vestibular System
Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI
Rapidly evolving virtual reality (VR) and augmented reality (AR) technologies are being incorporated by many large-scale industries, and the medical field is no exception.
- Trial name
- VR4VPT (NCT05326100)
- Testing
- Conventional Therapy (CPT), CAREN Therapy, Augmented Reality (AR) Therapy
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Naval Health Research Center
Mild Traumatic Brain Injury
Change in Connectivity After mTBI Depending on Cognitive Reserve
The purpose of this study is to investigate the role of cognitive reserve in change in connectivity in the brain (measured with functional magnetic resonance imaging, fMRI) and how this is related to symptoms and symptom…
- Trial name
- NCT05593172
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Danderyd Hospital
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Concussion, Mild, Neurocognitive Dysfunction
Biomarker Levels as A Predictor of Concussion Severity OUTcomes (BlacOut)
The overall research aim of this pilot study is to determine if the structural brain protein calpain-cleaved αII-spectrin N-terminal fragment (SNTF) can be used as a blood biomarker to accurately identify patients who will have…
- Trial name
- BlacOut (NCT02992327)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Brain Injury, Traumatic
Mild Traumatic Brain Injury Registry
The purpose of the study is to gather information about patients with mild traumatic brain injury in order to develop guidelines for evaluation and treatment.
- Trial name
- mTBI (NCT01688869)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Post-Traumatic Headache, Mild Traumatic Brain Injury
Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache
An exploratory open-label study of PPTH patients to study the efficacy and tolerability of erenumab in the prophylactic treatment of persistent headache attributed to mild traumatic injury to the head.
- Conditions
- Post-Traumatic Headache, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03974360
- Testing
- AMG 334
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Headache Center
Concussion, Brain
Neuraceq™ PET for Detection of Brain Changes in Young Athletes Post-concussion
The purpose of the study is to learn if Neuraceq™ (Florbetaben F 18 Injection) PET can detect changes in the brains of young athletes who sustained one or more concussions with or without persistent cognitive complaints at least…
- Trial name
- NCT05270083
- Testing
- NeuraCeq PET imaging with intravenous (IV) dose of 300MBq of Neuraceq™ ([F-18]Florbetaben)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Brain Concussion, Brain Trauma
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS).
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- NCT04925453
- Testing
- active tDCS and cognitive training intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- United States Naval Medical Center, San Diego
Mild Traumatic Brain Injury
OPTIMA-TBI Pilot Study
This is a double-blind, randomized controlled trial comparing the effect of omega-3 fatty acid versus placebo on blood biomarkers of brain injury, inflammation and neurogenesis.
- Trial name
- OPTIMA (NCT03345550)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Brain Injury Traumatic Mild
Web-Based Self-Monitoring Activity-Restriction and Relaxation Training Program for Kids With Mild Traumatic Brain Injury
SMART is an interactive web-based program that will allow youth with mild traumatic brain injuries (mTBI) to monitor their symptoms and receive education on problem-solving and coping strategies.
- Trial name
- SMART (NCT03498495)
- Testing
- Self-Monitoring Activity-restriction and Relaxation Training (SMART)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Intermediate
Unblinded Data Collection Study of Concussion Using BrainPulse
This is a prospective, non-blinded, matched control study of young athletes (ages 10-28 years old) in collegiate sports. The cohorts are defined in accordance to the athlete's exposure of injury.
- Trial name
- NCT02992795
- Testing
- BrainPulse
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Brain Concussion, Mild Traumatic Brain Injury
Get Going After concussIonN Lite
Background: Concussion affects around 25 000 people each year in Denmark. A large research initiative (GAIN 2.0) has been established, and the current study is a part of this initiative. Aims: 1.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Commotio Cerebri
- Trial name
- GAIN Lite (NCT05233475)
- Testing
- Enhanced usual care (EUC), Get Going after concussIoN Lite
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus