Clinical trials: Cerebral Concussion
Traumatic Brain Injury, Concussion, Brain
Understanding Concussion/Mild Traumatic Brain Injury
Using the Blink Reflexometer, athletes are scanned if they are potentially thought to have a concussion during a game or practice.
- Trial name
- NCT03381638
- Testing
- Blink Reflexometer
- Where
- 5 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Blinktbi, Inc.
Post-Traumatic Stress Disorder
Visual Dysfunction in Mild Traumatic Brain Injury (MTBI): A Comparison Group Study
In an on-going study of visual characteristics of personnel diagnosed with a mild traumatic brain injury (MTBI) related to their service in Iraq and Afghanistan we found a high rate of binocular vision problems (such as…
- Trial name
- VDMTBI (NCT00671450)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- US Department of Veterans Affairs
Mild Traumatic Brain Injury
OPTIMA-TBI Pilot Study
This is a double-blind, randomized controlled trial comparing the effect of omega-3 fatty acid versus placebo on blood biomarkers of brain injury, inflammation and neurogenesis.
- Trial name
- OPTIMA (NCT03345550)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Mild Traumatic Brain Injury
Symptom-Targeted Rehabilitation for Concussion
The investigators are comparing two methods for helping improve everyday cognitive functioning in Canadian Armed Forces (CAF) veterans who have sustained a mild traumatic brain injury (mTBI).
- Trial name
- STAR-C2 (NCT05520710)
- Testing
- Cognitive Rehabilitation, Education
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- McMaster University
Traumas, Brain, Alzheimer Disease
The COACH Project: Combined Online Assistance for Caregiver Health
This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia.
- Conditions
- Traumas, Brain, Alzheimer Disease, Dementia, Head Injury
- Trial name
- COACH (NCT03123224)
- Testing
- Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Traumatic Brain Injury
Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)
The overall goal is to determine whether perceptual or performance fatigue can be reduced in MTBI patients with and without growth hormone (GH) deficiency by treating them in a crossover fashion based upon GH status.
- Trial name
- NCT02114775
- Testing
- Growth Hormone, Sildenafil
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Concussion, Brain, Traumatic Brain Injury
Ghrelin (OXE--103) for Acute Concussion Management
Concussions are the leading form of mild traumatic brain injury. Management of concussions and mild traumatic brain injury is a high priority medical focus, social concern, and research topic.
- Trial name
- NCT04558346
- Testing
- Ghrelin (OXE-103)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Michael Rippee
Concussion, Convergence Insufficiency
Interventions for Convergence Insufficiency in Concussed Children
The ICONICC Study is a randomized controlled clinical trial designed to compare the proportion of successful treatment outcomes between children assigned to standard concussion care only, standard concussion care plus simple…
- Trial name
- ICONICC (NCT03908112)
- Testing
- Standard Community Concussion Care (SC), SC plus Simple Convergence Exercises (SC+), SC plus Office-based Vergence/Accommodative Therapy (SC+OBVAT)
- Where
- 8 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Mitchell Scheiman
Post-Concussion Symptoms, Distorted; Balance
Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion
Concussion or mild traumatic brain injury (TBI) is a challenging injury for physicians to manage and is among the most serious disabling neurological disorders.
- Trial name
- NCT02750566
- Testing
- Osteopathic Manipulative Treatment, Counseling
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- New York Institute of Technology
Sleep Disturbance, Traumatic Brain Injury
Mind-Body Rehabilitative Program for Veterans With mTBI (Mild Traumatic Brain Injury)
The broad aim of the proposed study is to evaluate the comprehensive benefit of a novel mind-body therapeutic intervention, Mind-Body Bridging (MBB), in Veterans who suffer from mTBI and sleep disturbance co-morbid with PTSD…
- Trial name
- NCT01975857
- Testing
- Mind-Body Bridging Program, Supportive Education
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- University of Utah
Mild Traumatic Brain Injury
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans…
- Trial name
- NCT06333990
- Testing
- Quetiapine Fumarate, TAU
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Foundation for Advancing Veterans' Health Research
Concussion, Brain Trauma
Field Implementation of iDETECT
The purpose of this study is to assess a new screening tool for sideline evaluation of concussion injuries in athletes. iDETECT is a new technology that combines several elements of recommended concussion screening tools into a…
- Trial name
- NCT02529618
- Testing
- integrated Display Enhanced Testing for Cognitive Impairment and mild traumatic brain injury (iDETECT), Riddell High Impact Technology (HIT) System, i1 Biometrics Vector Mouth Guard
- Where
- 4 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Emory University
Convergence Insufficiency
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI
The design of this project is a pilot study, a type of feasibility study conducted in preparation for subsequent RCTs that will assess the effectiveness of office-based vergence/accommodative therapy with movement (OBVAM) for…
- Trial name
- TBEye (NCT06848673)
- Testing
- Office-Based Vergence/Accommodative Therapy with Movement (OBVAM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salus University
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Cerebral Concussion, Brain Injuries
The Effects of Head Trauma on Collegiate Athletes
Recently, researchers and clinicians have examined many different forms of concussion testing aimed to assess if a brain injury has occurred and to what degree it affects the individual being tested.
- Trial name
- NCT02354469
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Concussion, Brain
Oculomotor Function Testing in Acute Concussion
This is a prospective longitudinal study which aims to compare oculomotor function and visual scanning behaviour (VSB) of participants who suffered concussion with healthy controls with no concussion.
- Trial name
- NCT03892356
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Mild Traumatic Brain Injury
Recovery Among Older Adults Following Mild TBI
Among fall related injuries in older adults, head injuries are the most common, yet almost nothing is known about recovery from head injury, also known as traumatic brain injury or TBI, in this population.
- Trial name
- NCT07569354
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Maryland, Baltimore
Cerebral Concussion
Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants
Healthy (non-injured) and concussed college-aged participants will complete two testing sessions that include (1) clinical symptom, balance, and cognitive evaluations and (2) a progressive exercise session to establish symptom…
- Trial name
- ACTIVE (NCT02872480)
- Testing
- ACTIVE Training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Concussion, Mild, Sleep
Impact of Concussion History on Sleep and Physical Performance in Contact Sports Athletes
This study investigates the correlation between a history of concussions and its effects on both sleep patterns and physical performance among athletes engaged in contact sports.
- Conditions
- Concussion, Mild, Sleep, Physical Performance
- Trial name
- NCT06328023
- Testing
- SCOAT 6 to find association
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University