Clinical trials: Cerebral Embolism
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Stroke Hemorrhagic
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care.
- Trial name
- REACH (NCT06870812)
- Testing
- Surgical management, Medical Management
- Where
- 24 sites in United States
- Volunteers
- 600 people
- Sponsor
- Emory University
Cerebral Venous Thrombosis
The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis
This is a single-center, prospective, randomized (1:1), open-label study with two parallel groups. This study is planned to investigate the efficacy and safety of dabigatran etexilate comparing with warfarin for the treatment of…
- Trial name
- NCT03217448
- Testing
- Dabigatran etexilate, Warfarin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Atrial Fibrillation, Cerebral Embolism
Left Atrial Appendage Closure During Open Heart Surgery
Because atrial fibrillation occurs frequently in heart surgery patients, our overall hypothesis is that systematic closing the left atrial appendage during surgery will reduce cerebral embolism coming from the thrombus formation…
- Conditions
- Atrial Fibrillation, Cerebral Embolism, Stroke
- Trial name
- LAACS (NCT02378116)
- Testing
- Surgical closure of the left atrial appendage
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Frederiksberg University Hospital
Infant Development, Infant,Premature
Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy
The study seeks to determine the efficacy of non-nutritive suck (NNS) training using a pacifier-activated device (PAM) with mothers' voice to condition suck-strength and rhythmicity, in improving the feeding and developmental…
- Conditions
- Infant Development, Infant,Premature, Hydrocephalus, Neonatal Encephalopathy
- Trial name
- NCT03230032
- Testing
- pacifier-activated device
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
This is a single-center prospective cohort study of predictive factors related to prognosis of ischemic stroke due to large-artery atherosclerosis.
- Trial name
- NCT04847752
- Testing
- carotid artery stenting, carotid endarterectomy, Aspirin
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Thromboembolic Events
Association of Genetic Variants With Risk of Stroke in Patients With Atrial Fibrillation Off-anticoagulation
Life-long therapy with oral anticoagulants (OAC) is strongly recommended in AF patients receiving left atrial appendage isolation (LAAI) to prevent thromboembolic (TE) events.
- Trial name
- GSAF (NCT04115436)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Peripheral Arterial Disease, Venous Thormboembolism
VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization
Venous thromboembolism (VTE) has a high prevalence in patients with multiple comorbidities undergoing complex surgical procedures.
- Conditions
- Peripheral Arterial Disease, Venous Thormboembolism, Cardiovascular Diseases, Vascular Surgery Patient with PAD / Carotid Stenosis
- Trial name
- RESOLUTION (NCT06873321)
- Testing
- rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Science Valley Research Institute
Stroke, PET
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke.
- Conditions
- Stroke, PET, Thrombosis
- Trial name
- TORPIS (NCT05636748)
- Testing
- 18F-GP1 PET/CT, Agitated Contrast Echocardiogram, MRI Head
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Cerebral Venous Sinus Thrombosis
Dabigatran Versus Apixaban in Cerebral Venous Thrombosis
Along with the current clinical trial, the efficacy and safety of a 150 mg Bid dabigatran administered within 24 hours of randomization after having first-ever cerebral venous thrombosis compared to apixaban 5mg Bid were assessed…
- Trial name
- NCT06551415
- Testing
- Dabigatran Etexilate 150mg, Apixaban 5MG
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kafrelsheikh University
Acute Coronary Syndrome, Heart Failure
A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa
FEVRIER study is an observatory of hospitalizations in cardiology units in sub-Saharan Africa.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Syncope, Stroke
- Trial name
- FEVRIER (NCT03231449)
- Testing
- observation of current care
- Where
- 20 sites in Benin, Burkina Faso and 11 more
- Volunteers
- 5,000 people
- Sponsor
- Cardiologie et Développement
Atrial Fibrillation, Thromboembolism
AMPLATZER™ LAA Occluder Post Approval Study (PAS)
The aim of this multicenter, non-randomized observational post-approval is to compile real world outcome data on the use of an AMPLATZER LAA Occluder in subjects with non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Thromboembolism, Stroke
- Trial name
- NCT02964208
- Testing
- AMPLATZER™ LAA Occluder
- Where
- 22 sites in Argentina, Belgium and 5 more
- Volunteers
- 520 people
- Sponsor
- Abbott Medical Devices
Carotid Artery Stenosis
Evaluation of the 3-in-1 Neuroguard IEP System for Carotid Artery Stenosis
The Neuroguard IEP System is a 3-in-1 carotid stent delivery system consisting of an angioplasty balloon, an integrated embolic protection device and a nitinol self-expanding stent loaded over the balloon and constrained by an…
- Trial name
- PERFORMANCE (NCT04142541)
- Testing
- Neuroguard® IEP 3-in-1 Carotid Stent and Post-Dilation Balloon System with Integrated Embolic Protection (Neuroguard IEP System)
- Where
- 6 sites in Germany, Italy
- Volunteers
- 67 people
- Sponsor
- Contego Medical, Inc.
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Carotid Artery Stenosis
EPIC European Study: Use of the FiberNet® Emboli Protection Device in Carotid Artery Stenting
Multicenter, prospective, study designed to demonstrate the performance and safety of the Lumen Biomedical, Inc. FiberNet Embolic Protection System as an adjunctive device during carotid artery percutaneous intervention.
- Trial name
- NCT00309803
- Testing
- FiberNet Embolic Protection Device
- Where
- 3 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Lumen Biomedical
Venous Thromboembolism, Traumatic Brain Injury
Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Brain injured patients are at high risk for forming blood clots in the legs and lungs. For non-brain injured trauma patients, we decrease the chances of these blood clots forming by placing the patients on a low dose of the blood…
- Trial name
- DEEP (NCT01014403)
- Testing
- enoxaparin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Atrial Fibrillation, Left Atrial Thrombosis
Left Atrial Thrombus Reduction - Effect of Dabigatran Versus Phenprocoumon
This is a single-center, randomized, two treatment groups, open, phase IV clinical study in subjects with atrial fibrillation and left atrial thrombus.
- Trial name
- NCT02591225
- Testing
- Dabigatranetexilate, Phenprocoumon
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Ulm