Clinical trials: Cerebral Embolism and Thrombosis
Myocardial Infarction, Acute Disease
Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction
This project aims to assess the ability of cardiac imaging (cardiac MRI and Doppler-echocardiography) post-processing tools to predict a combined end-point of intraventricular thrombosis, silent brain infarcts, clinical stroke…
- Conditions
- Myocardial Infarction, Acute Disease, Thrombosis, Heart Diseases
- Trial name
- ISBITAMI (NCT02917213)
- Testing
- Doppler echocardiogram exam, Carotid duplex ultrasound exam, Cardiac MRI
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Intracranial Embolism, Thrombosis
Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
The purpose of the present, randomized, controlled multicenter phase III trial is to investigate the safety and efficacy of continuous 1-hour insonation of occluded middle cerebral artery with 2 MHz TCCS in stroke patients…
- Trial name
- NCT00336596
- Testing
- transcranial ultrasound in patients treated with iv t-PA
- Where
- 6 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Transient Ischemic Attack, Thromboembolic Stroke
Carotid Artery Revascularization Using the Boston Scientific EPI Filter Wire EZ™ and the EndoTex™ NexStent™
The primary objective of this study is to demonstrate the safety of the NexStent for treatment of carotid artery lesions undergoing stenting with adjunctive use of the FilterWire distal embolic protection device.
- Conditions
- Transient Ischemic Attack, Thromboembolic Stroke, Stroke Prevention
- Trial name
- CABERNET (NCT00600327)
- Testing
- EndoTex™ NexStent™, Filter Wire EZ™
- Where
- 19 sites in United States, Argentina and 1 more
- Volunteers
- 488 people
- Sponsor
- Boston Scientific Corporation
Deep Vein Thrombosis Leg, Stroke (in Patients With Atrial Fibrillation)
A Healthy Volunteer Study to Investigate the Blood Concentrations, the Effect on Blood Clotting and the Safety of Multiple Doses of DPOC-4088 Tablets in Different Doses.
A study to investigate the concentrations of a new drug DPOC-4088 in blood, and to study the effect of this drug on blood clotting parameters.
- Trial name
- NCT01647620
- Testing
- DPOC-4088
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diakron Pharmaceuticals
Stroke, Acute, Thrombosis
RNA Sequencing Analysis in Large Vessel Occlusion Stroke DATA Bank
Introduction: the source of embolic stroke , in thrombotic embolism , is of unknown origin in 30-40% of cases. Fortunately , Mechanical thrombectomy provide a direct method to retrieve the stroke-incriminated clots from stroke…
- Trial name
- RNASA-LVOSB (NCT03490552)
- Testing
- mechanical thrombectomy
- Where
- Egypt
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Society of Minimally Invasive Neurological Therapeutic Procedures
Thrombosis, Stent Thrombosis
Evaluating Pharmacogenomic Variants for Cardiology Therapeutics
Cipherome's Lighthouse is a clinical decision support tool that incorporates a patient's pharmacogenetic information to determine therapeutic strategy, including determining appropriate dosage or assessing the likelihood of…
- Conditions
- Thrombosis, Stent Thrombosis, Bleeding, Myocardial Infarction
- Trial name
- CARES2 (NCT04702113)
- Testing
- Cipherome Lighthouse Pilot
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cipherome, Inc.
Coronavirus Disease 2019
Covid-19 Associated Coagulopathy Predicted by Thrombodynamic Markers (CoViTro-I)
The aim of the study is estimating the predictive and preventative capability of thrombodynamics for severe pneumonia coagulopathy complications in patients with COVID-19 infection.
- Trial name
- NCT05330832
- Testing
- Thrombodynamics test
- Where
- Russia
- Volunteers
- 2,200 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Atrial Fibrillation
Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Latinamerica and EMEA Region
This international study is a prospective noninterventional observational cohort study of patients with non-valvular atrial fibrillation who are prescribed rivaroxaban under routine treatment conditions to prevent stroke or…
- Trial name
- XANTUS-EL (NCT01800006)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- 17 sites in Argentina, Azerbaijan and 15 more
- Volunteers
- 2,101 people
- Sponsor
- Bayer
Cerebral Vein Thrombosis
Rivaroxaban vs. Warfarin in CVT Treatment
Cerebral venous thrombosis (CVT) is an uncommon venous-type of stroke tends to affect younger patients with somewhat different risk factors and much better outcome compared to arterial strokes.
- Trial name
- RWCVT (NCT04569279)
- Testing
- Rivaroxaban, Warfarin
- Where
- Syria
- Volunteers
- 71 people
- Sponsor
- Damascus University
Cerebral Vein Thrombosis
Venous Sinus Thrombosis : Clinical Picture and Outcome
Cerebral venous sinus thrombosis (cvst) is an underdiagnosed neurological condition with variable clinical presentations and variable risk factors CVST is often an underdiagnosed cause of acute or slowly progressive neurological…
- Trial name
- NCT05211102
- Volunteers
- 50 people
- Sponsor
- Assiut University
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 91 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Cerebral Venous Sinus Thrombosis, Stroke
Danang Cerebral Venous Thrombosis Registry
Cerebral venous thrombosis (CVT) is an uncommon but potentially life-threatening type of stroke, predominantly affecting young adults and women.
- Conditions
- Cerebral Venous Sinus Thrombosis, Stroke, Cerebral Venous Thrombosis
- Trial name
- DANANG-CVT (NCT07890675)
- Testing
- Standard Anticoagulant Therapy
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Da Nang Hospital
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cerebral Embolism, Stroke
Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients
The purpose of this study is to determine whether autologous bone marrow mononuclear cells transplantation after stroke is safe and/or effective to improve neurological outcome.
- Trial name
- NCT01028794
- Testing
- autologous bone marrow mononuclear cells
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Ischemic Stroke
Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCI™])
The primary objectives of the Multi MERCI trial were: to evaluate the addition of the Merci L5 Retriever additionally permit use of the Merci Retrieval System in the setting of persistent clot following IV t-PA treatment (use in…
- Trial name
- Multi-MERCI (NCT00318071)
- Testing
- Merci Retriever
- Volunteers
- 164 people
- Sponsor
- Stryker Neurovascular
Thrombosis, Acute Coronary Syndrome
Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Primary objective: To evaluate safety and tolerability, adverse events (AEs), vital signs, ECG, bleeding time, evaluation of antibody titer and safety laboratory tests Secondary objectives: To evaluate the pharmacokinetics and…
- Conditions
- Thrombosis, Acute Coronary Syndrome, Myocardial Infarction, Stroke
- Trial name
- PR-15/01 (NCT01042964)
- Testing
- revacept (PR-15)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdvanceCor GmbH
Brain Tumor, Stroke, Acute
Safety and Feasibility of the Infinity Catheter for Radial Access
The main objective of this single arm study is to evaluate the safety and feasibility of the AXS Infinity LS (Stryker, Freemont, CA, USA) and AXS Infinity LS Plus (Stryker, Freemont, CA, USA) catheters during the transradial…
- Conditions
- Brain Tumor, Stroke, Acute, Brain Aneurysm, Intracranial Arteriovenous Malformations
- Trial name
- NCT04553549
- Testing
- Transradial approach
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Stroke
Study to Assess the Safety and Effectiveness of the Penumbra System
This clinical evaluation is a prospective, single-arm, multi-center trial. The purpose of this clinical evaluation is to assess the safety and effectiveness of the Penumbra System in the revascularization of patients presenting…
- Trial name
- NCT00334061
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penumbra Inc.
Patent Foramen Ovale, Cardiac Implantable Electronic Device
Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli
Patients with a patent foramen ovale in the setting of endocardially placed cardiac implantable electronic devices such as pacemakers, defibrillators, or resynchronization therapies are likely at higher risk for paradoxical…
- Trial name
- PARADOX (NCT02378623)
- Testing
- Apixaban
- Where
- United States
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Atrial Flutter
Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk
The IMPACT Study will investigate the potential clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) technology and a predefined anticoagulation plan compared to conventional device evaluation and…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Stroke, Embolism, Systemic Arterial
- Trial name
- IMPACT (NCT00559988)
- Testing
- Home Monitoring Guided OAC, Physician-Directed OAC
- Where
- 80 sites in United States, Australia and 4 more
- Volunteers
- 2,718 people
- Sponsor
- Biotronik, Inc.