Clinical trials: Cerebral Infarct
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, CVA (Cerebrovascular Accident)
MORbidity PRevalence Estimate In StrokE
Information regarding the likely progress of post-stroke symptoms is vitally important to stroke survivors to allow them to plan for the future and to adjust to life after stroke.
- Conditions
- Stroke, CVA (Cerebrovascular Accident), CVA; Sequelae, Stroke, Ischemic
- Trial name
- MORe PREcISE (NCT03605381)
- Where
- 3 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Aneurin Bevan University Health Board
Heparin Causing Adverse Effects in Therapeutic Use, Heparin-induced Thrombosis
Study on Continuous Intravenous of Unfractionated Heparin (UFH) to Treat Progressive Cerebral Infarction
A clinical trial to study the effects of dosage, infusion methods and complications of unfractionated heparin (UFH) treating acute progressive cerebral infraction was conducted.
- Conditions
- Heparin Causing Adverse Effects in Therapeutic Use, Heparin-induced Thrombosis, Acute Cerebral Ischemia
- Trial name
- UHPCI (NCT01378000)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Cerebral Ischemia
Desflurane Versus Propofol in the Sitting Position
The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.
- Trial name
- NCT01436799
- Testing
- propofol, Desflurane, alfentanil
- Volunteers
- 40 people
- Sponsor
- Gachon University Gil Medical Center
Acute Ischemic Stroke, Posterior Circulation Brain Infarction
Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions.
- Conditions
- Acute Ischemic Stroke, Posterior Circulation Brain Infarction, Arterial Occlusion Disease
- Trial name
- PC-CBS (NCT07122934)
- Testing
- Assessment of cervico-cerebral arterial occlusion pattern
- Volunteers
- 1,828 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Brain Ischemia
Functional Outcomes in Patients With Cerebral Infarction After Aquatic Physiotherapy and Aerobic Exercise
The aim of the study was to evaluate changes in functional outcomes in patients with cerebral infarction following aquatic physiotherapy and aerobic exercises during the second stage of rehabilitation.
- Trial name
- NCT07861009
- Testing
- Aquatic physiotherapy, Aerobic exercises
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- Lithuanian University of Health Sciences
Cerebral Infarction
BRUSH Sign: Radiolographic Marker of Cerebral Infarctus Prognosis
Today the treatment of ischemic stroke in acute phase is based on medicinal or endovascular revascularization. Cerebral MRI sequences help the diagnostic. This procedure uses deoxyhemoglobin as an endogenous tracer.
- Trial name
- NCT03467269
- Testing
- Brush sign
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Stable Angina, Unstable Angina
Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study
Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial…
- Conditions
- Stable Angina, Unstable Angina, Myocardial Infarction, Unheralded Coronary Heart Disease Death
- Trial name
- NCT03425305
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Cerebral Infarction
Evaluation of the Safety and Potential Therapeutic Effects of Cordstem-ST in Patients With Cerebral Infarction
The objective of the study is to evaluate the safety and the potential therapeutic effects per dose of Cordstem-ST Intravenous Transplantation in Cerebral Infarction subjects
- Trial name
- NCT02378974
- Testing
- Cordstem-ST
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- CHABiotech CO., Ltd
Stroke, Large Ischemic Core
Assessing Local Hypothermia and Endovascular Recanalization for Acute Stroke With a Large Core Infarction
A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for…
- Trial name
- RESCUE-LCI (NCT07232082)
- Testing
- intra-arterial local therapeutic hypothermia, Control (Normal saline)
- Volunteers
- 322 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage
Patients with brain hemorrhage resulting from a ruptured aneurysm (SAH) are at risk of developing a condition called vasospasm, one or two weeks after their hemorrhage. This is a major cause of stroke and death following SAH.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Cerebral Vasospasm, CT Perfusion
- Trial name
- CT-PIPS (NCT02056769)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Nova Scotia Health Authority
Anarthria, Dysarthria
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to…
- Conditions
- Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Speech-02 (NCT06094205)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca
Ischemic Stroke
Myocardial Damage In Patients With Cerebral Infarction
Introduction For several years "ischemic" electrocardiographic (ECG) changes in the acute phase of ischemic stroke have been reported. Whether these ECG changes reflect true myocardial ischemia remains controversial.
- Trial name
- NCT00306579
- Volunteers
- 250 people
- Sponsor
- Danish Heart Foundation
Dementia
Comparative Study Between Alzheimer's and Multi-infarct Dementia
Dementia is a neurological disease that causes cognitive and behavioral impairments that could ultimately interfere with the ability to function at work or to do the usual daily activities.
- Trial name
- NCT05781139
- Testing
- levels of Neurofilaments (NfL) in serum
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Assiut University
Cerebral Infarct
Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia
Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and thrombectomy).
- Trial name
- THINK (NCT02948465)
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Hopital Foch
Stroke, Ischemic, Intracranial Atherosclerosis
Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study
Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT).
- Conditions
- Stroke, Ischemic, Intracranial Atherosclerosis, Posterior Circulation Brain Infarction
- Trial name
- NCT06453252
- Testing
- we are aiming to develop a Scoring system based on certain variables derived from both groups
- Where
- 2 sites in United States, Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Aneurysmal Subarachnoid Haemorrhage
Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Dynamic 18F-FDG PET/CT
A pilot trial for assessing early microvascular alterations after aneurysmal subarachnoid hemorrhage using dynamic 18F-FDG PET/CT.
- Trial name
- PREDISP (NCT04356599)
- Testing
- Early dynamic 18F-FDG PET/CT assessment of cerebral glucose uptake
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier
Stroke, Cerebral Infarction
Efficacy and Safety Study of Neu2000KWL for Acute Ischemic Stroke Patients Within 6 Hours of Onset
The purpose of the study is to explore safety and efficacy of Salfaprodil administration for patients with acute ischemic stroke within 6 hours of onset.
- Trial name
- Salfaprodil (NCT04486430)
- Testing
- Neu2000KWL
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Beijing Tiantan Hospital
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