Clinical trials: Cerebral Infarction
Stroke, Cerebral Infarction
Enhancing Physical Therapy Best Practice for Improving Walking After Stroke
The aim of this study is to assess the effect of implementing best practices into current stroke rehabilitation physical therapy on walking outcomes.
- Conditions
- Stroke, Cerebral Infarction, Brain Ischemia, Infarction, Brain
- Trial name
- NCT04238260
- Testing
- Enhancing Physical Therapy Usual Care, Physical Therapy Usual Care
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- University of British Columbia
Cerebral Infarction, Cerebral Infarction Recovery
D-dimer Prognostic Marker of Cerebral Infarction After Revascularization Procedure
Cerebral infarction is the leading cause of acquired disability in adults. Absence of biological marker used in current practice and identified as a prognostic factor for recovery.
- Trial name
- D-Dimer (NCT04938479)
- Testing
- blood sample
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke, Ischemic Stroke
Stroke Prevention In Ischemic Stroke With Covert Atrial Fibrillation
Patients who have recently had an ischemic stroke with no clear cause might have undetected atrial fibrillation (AF) that isn't caught during their initial hospital stay.
- Conditions
- Stroke, Ischemic Stroke, Cerebral Infarction, Atrial Fibrillation
- Trial name
- SPICAF (NCT06486792)
- Testing
- Apixaban, Aspirin
- Where
- France
- Volunteers
- 1,148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Middle Cerebral Artery Infarction
Roods vs PNF for Upper Limb Function in Acute MCA Stroke
Middle cerebral artery (MCA) stroke often causes weakness or stiffness in the arm and hand, making daily activities difficult. This study compares two physical therapy approaches - Rood's facilitatory techniques (using touch…
- Trial name
- RVP-MCA (NCT07616622)
- Testing
- Neuromuscular Electrical Stimulation, Rood's Facilitatory Techniques, Proprioceptive Neuromuscular Facilitation
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- University of Faisalabad
Stroke
Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicenter Randomized Controlled Trial (IVT-ALL-IN)
Stroke is a frequent and severe disease worldwide, representing the second leading cause of death and the leading cause of acquired disability.
- Trial name
- IVT-ALL-IN (NCT07603440)
- Testing
- Intravenous administration, MT alone
- Where
- 36 sites in France
- Volunteers
- 486 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Ischemic Stroke
Mexidol® Safety and Efficacy in Treatment of Hyperacute and Acute Ischemic Stroke
The primary objective of this study is to further define the mechanisms of action of Mexidol® (solution for intravenous and intramuscular injection, 50 mg/ml) and Mexidol® FORTE 250 (film-coated tablets, 250 mg) in the hyperacute…
- Trial name
- NCT07575984
- Testing
- Mexidol, Glycine
- Where
- 9 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pharmasoft
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cerebral Infarction, Thrombolysis
Early Low-dose ASpirin Use After Intravenous Thrombolysis for Acute Ischemic Cerebral Infarction（ELASTIC）
This study evaluates whether early administration of low-dose aspirin (100mg) at 2 hours post-intravenous thrombolysis, compared to the standard timing of 24 hours, improves functional outcomes in patients with acute ischemic…
- Trial name
- ELASTIC (NCT07563673)
- Testing
- Aspirin (Early, 2h), Aspirin (Standard, 24h)
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Cerebral Infarction
Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period.
This is a randomized, double-blind study. Human umbilical cord mesenchymal stem cells (hUC-MSC) will be treated on cerebral infarction patients, and evaluates their neurological function of convalescent period.
- Trial name
- NCT03176498
- Testing
- Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Cerebral Infarction
The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction
The purposes of the study is to determine the safety and efficacy of treating acute ischemic stroke patients with human umbilical cord mesenchymal stem cells (hUC-MSC).
- Trial name
- NCT03186456
- Testing
- Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Ischemic Cerebral Infarction
Ongericimab Injection Reducing Recurrence of Ischemic Stroke
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by…
- Trial name
- ORIS (NCT07242599)
- Testing
- High target group, Low target group
- Where
- 199 sites in China
- Volunteers
- 4,810 people
- Sponsor
- Beijing Tiantan Hospital
Aphasia Following Cerebral Infarction
Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia
Research question Does participation in an Intensive Comprehensive Aphasia Programme produce a meaningful change in the communication of people with aphasia, their quality of life and that of their carers? Background Aphasia is a…
- Trial name
- RCT of an ICAP (NCT07386652)
- Testing
- ICAP, Standard Care (in control arm)
- Where
- United Kingdom
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University College, London
Acute Cerebral Infarction
Correlation Analysis Between Peripheral Blood PrPC Levels and Disease Severity and Prognosis in Patients With Acute Cerebral Infarction
The primary objective of this observational study is to investigate alterations in PrPc levels in peripheral blood during acute cerebral infarction, as well as the correlation between these changes and both disease severity and…
- Trial name
- NCT07513428
- Where
- China
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Cerebral Infarction, Stenosis Artery
The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis
Currently, aspirin plus clopidogrel is considered as a standard acute treatment of ischemic stroke, based on results of CHANCE and POINT trial.
- Trial name
- CHANGE (NCT06757764)
- Testing
- Aspirin, Clopidogrel, Cilostazol
- Where
- 24 sites in South Korea
- Volunteers
- 2,340 people
- Sponsor
- Asan Medical Center
Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option.
- Conditions
- Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- NCT07496645
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Carotid Artery Stenosis, Cerebral Infarction
Bacteria in Atherosclerotic Plaques and Adverse Events
This study is a prospective, multicenter cohort study conducted in western China. The registry study is primarily conducted at the Department of Neurosurgery, Tangdu Hospital, with participation from the Departments of…
- Conditions
- Carotid Artery Stenosis, Cerebral Infarction, Diabetes, Bacteria
- Trial name
- NCT06935279
- Testing
- Carotid Endarterectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley
Infarction, Brain
CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria
Diagnostic performance of a novel protocol for computed tomography-angiography, as ancillary test in the determination of complete cerebral infarction, in comparison to four vessel angiography.
- Trial name
- Tadaa (NCT07341490)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Stockholm