Clinical trials: Cerebral Infarction
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage
Patients with brain hemorrhage resulting from a ruptured aneurysm (SAH) are at risk of developing a condition called vasospasm, one or two weeks after their hemorrhage. This is a major cause of stroke and death following SAH.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Cerebral Vasospasm, CT Perfusion
- Trial name
- CT-PIPS (NCT02056769)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Nova Scotia Health Authority
Endocrine Dysfunction, Cerebral Infarctions
Endocrine Dysfunction and Quality of Life After Subarachnoid Hemorrhage
Investigation of the incidence of endocrine dysfunction following subarachnoid hemorrhage (SAH), and to see if this has a relation to CNS lesions as evaluated by MRI and to common symptoms after SAH such as general exhaustion…
- Conditions
- Endocrine Dysfunction, Cerebral Infarctions, Quality of Life
- Trial name
- NCT01101711
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University Hospital
Cadasil, Blood Brain Barrier Defect
MRI Study of Blood-brain Barrier Function in CADASIL
Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB).
- Trial name
- NCT05902039
- Testing
- MRI
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Cerebrovascular Accident, Transient Ischemic Attack
The Post Stroke Preventive Trial (PREVENT). A RCT Nested in a Cohort Study
Patients with a diagnosis of stroke or TIA, who are already included in the RIALTO-cohort study are asked to participate in a RCT after discharge from hospital.
- Conditions
- Cerebrovascular Accident, Transient Ischemic Attack, Myocardial Infarction
- Trial name
- PREVENT (NCT00253097)
- Testing
- Intervention
- Where
- 2 sites in Denmark
- Volunteers
- 353 people
- Sponsor
- Hvidovre University Hospital
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage
Prospective evaluation of patients with subarachnoid hemorrhage (SAH) will be done by computed tomography angiography (CTA) and perfusion imaging (CTP) for any correlation between degree of vasospasm and perfusion deficit as well…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Delayed Cerebral Ischemia
- Trial name
- NCT03214705
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Cerebral Ischemia
Autologous Mitochondrial Transplant for Cerebral Ischemia
The investigators propose to infuse healthy autologous mitochondria into cerebral vessels supplying brain tissue experiencing ischemia in patients who undergo standard-of- care endovascular reperfusion therapy.
- Trial name
- NCT04998357
- Testing
- Endovascular autologous mitochondrial transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Stroke, Small Vessel Cerebrovascular Disease
Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant Adaptation
Cerebral infarction (ischemic stroke) and cerebral small vessel disease (CSVD) represent major global causes of disability, cognitive decline, and mortality.
- Trial name
- SHIELD (NCT07503301)
- Testing
- Medical-grade ischemic preconditioning training instrument, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subarachnoid Hemorrhage
S100B Kinetic During the Occurrence and Treatment of Delayed Cerebral Ischaemia After a Subarachnoid Haemorrhage.
Nearly half of the survivors of subarachnoid haemorrhage (SAH) retain irreversible neurological damage resulting from the early lesions associated with the initial bleeding, and the occurrence of possible delayed cerebral…
- Trial name
- SKinDCI (NCT04795362)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Infarction
Transcranial Direct Current Stimulation Combined With Intermittent Oral to Esophageal Tube on Dysphagia
The study is a double-blind randomized controlled trial, lasting for 15 days for each participant. Patients with post-stroke dysphagia who receive treatment at the Rehabilitation Department are selected as the study subjects.
- Trial name
- IOE+JLCJ-S (NCT06265779)
- Testing
- Comprehensive rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Zeng Changhao
Cerebral Infarction
Research on Binaural Synchronous Vagus Nerve Regulation of Sensorimotor Disorders After Cerebral Infarction
The aim of this study is to determine the efficacy and safety of binaural synchronous vagus nerve regulation in the treatment of patients with sensory and motor dysfunction after cerebral infarction through a randomized…
- Trial name
- NCT07081568
- Testing
- transcutaneous auriculai vagus nerve stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanchang University Affiliated Rehabilitation Hospital
Coronary Artery Disease
the Change of CEM and the Prognosis of Coronary Artery Disease in Real Clinical Practice
The purpose of this study is to investigate the change of total cholesterol content of erythrocyte membranes (CEM) in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the…
- Trial name
- CCEMPCAD (NCT03473860)
- Volunteers
- 200 people
- Sponsor
- Lu'an Municipal Hospital
Cerebral Ischemia
: External Shunt Versus Internal Shunt for Off Pump Glenn
A prospective, randomized comparative study where investigators present results of off pump bidirectional Glenn operation done using either a venoatrial shunt or external shunt to decompress superior vena cava during clamping.
- Trial name
- NCT05294718
- Testing
- Internal shunt, External shunt
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Stroke, Myocardial Infarctions
Letigen® and Cardiovascular Morbidity
Letigen® was a combination drug containing ephedrine, an adrenergic agonist with lipolytic and appetite-inhibiting properties. The drug was used as adjuvant treatment of obesity from 1990 and up to 2002 when it was withdrawn from…
- Conditions
- Stroke, Myocardial Infarctions, Sudden Death
- Trial name
- NCT00692666
- Volunteers
- 300,000 people
- Sponsor
- University of Southern Denmark
Ischemic Stroke
Predictors and Prognostic Factors on the Acute Ischemic Stroke
Through 5 years continuous observation of acute ischemic stroke patients in Neurology Department of Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, clinical data about emergency treatment…
- Trial name
- NCT03122002
- Testing
- Drug Therapy, Routine Blood Test and Image Scan, Intravascular therapy
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Tongji Hospital
Cerebral Infarction
Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke
This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.
- Trial name
- CUSCAS (NCT03115242)
- Testing
- Contrast injection Sonovue®
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Versailles Hospital
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Cambridge 7 Tesla Cerebral Small Vessel Disease Study
CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Lacunar Stroke
- Trial name
- CamSVD (NCT04330222)
- Testing
- 7 Tesla Magnetic Resonance Imaging, Brief Memory and Executive Test
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end organ damage and unfavourable prognosis, whereas…
- Conditions
- Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy, Myocardial Infarction, Stroke
- Trial name
- GENHART (NCT01173029)
- Testing
- Anti-hypertensive drug treatment
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Universidade Gama Filho