Clinical trials: Cerebral Oxygenation, open to volunteers
Cerebral Aneurysm
NIRS and BIS Monitoring During Cerebral Aneurysm Coiling
This prospective observational study aims to evaluate the effectiveness of Near-Infrared Spectroscopy (NIRS) and Bispectral Index (BIS) monitoring during endovascular coil embolization of cerebral aneurysms under general…
- Trial name
- NIRSBIS-ANEUR (NCT07438275)
- Testing
- Near-Infrared Spectroscopy (NIRS) and Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Dokuz Eylul University
Extremely Low Birth Weight Infants
Post-Extubation Assessment of Clinical Stability in ELBW Infants
This is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation…
- Trial name
- PEACE (NCT06037083)
- Testing
- Oxygen saturation probe, Near infrared spectroscopy sensors, Electrical impedance tomography
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Carotid Endarterectomy, Cerebral Autoregulation
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy
Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%.
- Trial name
- NCT06406842
- Testing
- Cerebral oxygenation index guided hemodynamics management
- Where
- 2 sites in China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Sleep-disordered Breathing (SDB)
Sleep-disordered Breathing and Neurocognitive Assessment in Children and Young Adults
One of main problems in the management of sleep-disordered breathing (SDB) in children and young adults is their screening, and the absence or the weak correlation between clinical symptoms and polysomnography (PSG).
- Trial name
- TRSPed (NCT04971850)
- Testing
- Sleep study
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Death, Brain
Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)
Brain death (BD) is characterized by a severe brain injury resulting in irreversible loss of all brain and brainstem functions, while other organs may remain viable.
- Trial name
- APNEAFLO2W (NCT07640009)
- Testing
- Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO.
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cerebral Oxygenation
Effect of Left Paratracheal Pressure on Cerebral Oxygenation During General Anesthesia
Left paratracheal pressure (LPP) has been proposed as an alternative to cricoid pressure to reduce the risk of regurgitation during induction of general anesthesia.
- Trial name
- PARANIRS (NCT07778303)
- Testing
- Left Paratracheal Pressure, Cricoid Pressure
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Clinique Saint-Luc
Diabetes Mellitus, Glycemic Control
Effect of Glycemic Control on Intraoperative NIRS and Postoperative Recovery in Diabetic Patients
This prospective observational study aims to evaluate the effect of glycemic control level on intraoperative cerebral oxygenation measured by near-infrared spectroscopy (NIRS) and postoperative recovery in patients with diabetes…
- Conditions
- Diabetes Mellitus, Glycemic Control, Cerebral Oxygenation, Anesthesia
- Trial name
- NIRS-DM (NCT07491185)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ege University
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Newborn; Vitality, Nursing Caries
Effect of Intranasal Breast Milk Administration in Preterm Infants
The aim of the study was to investigate the effect of intranasal breast milk administration on cerebral oxygenation level, vital signs and time to full oral feeding in preterm infants.
- Conditions
- Newborn; Vitality, Nursing Caries, Breast Feeding
- Trial name
- NCT06706115
- Testing
- Intranasal human breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cerebral Oxygen Saturation, Postoperative Delirium
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive…
- Conditions
- Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy
- Trial name
- NCT05198635
- Testing
- local cerebral oxygen saturation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Lumbar Disc Herniation, Respiratory Mechanics
Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc Surgery
This prospective observational study aims to evaluate the relationship between changes in respiratory mechanics and cerebral oxygenation in adult patients undergoing elective lumbar disc surgery in the prone position under…
- Conditions
- Lumbar Disc Herniation, Respiratory Mechanics, Cerebral Oxygenation
- Trial name
- NCT07862257
- Testing
- Prone Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Postoperative Complications, Intracranial Surgery
Blood Viscosity and Outcomes After Elective Craniotomy
This prospective observational study aims to evaluate the association between intraoperative blood viscosity and postoperative clinical outcomes in adult patients undergoing elective intracranial craniotomy.
- Trial name
- NCT07530393
- Testing
- Observational Assessment of Blood Viscosity
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Asan Medical Center
Ischemic Stroke
Oxygen Concentration Target in Stroke Endovascular Treatment
The goal of this clinical trial is to compare the effects of different concentrations of normobaric oxygen on early neurological improvement in acute ischemic stroke (AIS) patients receiving endovascular therapy (EVT).
- Trial name
- Oxy-TARGET (NCT06224426)
- Testing
- Normobaric high-concentration oxygen, Normobaric low-concentration oxygen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
ıntraoperative Cerebral Oxygenation, Cerebral Oxygenation Monitoring
Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy
Study Population: Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included. Study Design: This is an observational study.
- Trial name
- NCT07517146
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Spinal Anesthesia-Induced Hypotension, Cerebral Oxygenation
Effects of Ondansetron Timing During Spinal Anesthesia for Urologic Surgery
This study will evaluate whether the timing of intravenous ondansetron administration affects cerebral oxygenation and hemodynamic stability in older adults undergoing endoscopic urologic surgery under spinal anesthesia.
- Trial name
- NCT07858149
- Testing
- Ondansetron 8 mg, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Istanbul University
Cerebral Oxygenation, Peripheral Oxygenation
Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients
The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in…
- Conditions
- Cerebral Oxygenation, Peripheral Oxygenation, Geriatrics, Ventilation
- Trial name
- NCT07582913
- Testing
- Manual Mask Ventilation, AutoFlow Mechanical Mask Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Ankara City Hospital Bilkent
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
Cardiogenic Shock, Extracorporeal Life Support
Post-Surgery Extracorporeal Life Support
Extracorporeal Life Support (ECLS) may provide pulmonary and circulatory support for patients with acute heart failure refractory to conventional medical therapy.
- Conditions
- Cardiogenic Shock, Extracorporeal Life Support, Extracorporeal Membrane Oxygenation Complication, Post Cardiac Arrest Syndrome
- Trial name
- PC-ECLS (NCT04330651)
- Testing
- ECLS
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Airway Reactivity, Hemodynamic Stability During Anesthesia
ETCO₂ Targeting and Cerebral Oxygenation
This study looked at a safer way to prepare patients for anesthesia before major spinal surgery. Instead of using advanced or complex oxygen devices, the approach will use standard oxygen methods, guided by the patient's…
- Trial name
- NCT07526077
- Testing
- regional cerebral oxygen saturation
- Where
- Saudi Arabia
- Volunteers
- 70 people
- Sponsor
- Prince Sultan Military Medical City
Interscalene Block, Superficial Cervical Block
Comparison Of The Effects Of Regional Anesthesia On Brain And Carotid Artery Oxygenation In Shoulder Surgery
The aim of our study was to compare the effects of interscalene block alone and the combination of interscalene block and superficial cervical block on cerebral oxygenation, carotid artery diameter, intraoperative hemodynamics…
- Conditions
- Interscalene Block, Superficial Cervical Block, Cerebral Perfusion, Shoulder Surgeries
- Trial name
- NCT07398352
- Testing
- Interscalene brachial plexus block, Interscalene brachial plexus block and superficial cervical plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital