Clinical trials: Cerebral Vascular Disorder
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
The Danish Out-of-Hospital Cardiac Arrest Study
After resuscitation from Out-of-Hospital Cardiac Arrest (OHCA) patients experience Post Cardiac Arrest Syndrome due to ischemia and reperfusion injury.
- Trial name
- DANOHCA (NCT05895838)
- Testing
- Dexamethasone, Backrest elevation, Early wakeup call
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Hassager
Stroke, Ischemic Stroke
Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
This pilot trial will be the first step toward direct comparison of delivery of endovascular reperfusion therapy to intravenous recombinant tissue plasminogen activator (rt-PA) in a time-to-treatment framework shown as most…
- Trial name
- EARLY (NCT01869478)
- Testing
- Intravenous Thrombolysis, Endovascular Arterial Reperfusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Hypoxia-Ischemia, Brain, Periventricular Leukomalacia
Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury
The investigators propose to compare the proteomic analysis of umbilical venous blood from neonates with brain injury to gestational age matched noninjured controls.
- Trial name
- NCT00375908
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Acromegaly
Physiopathology of Sodium Retention in Acromegaly
Acromegaly is a disease due to an excess of growth hormone that abnormally occurs in adulthood. It is due to a benign (non cancerous) tumor located in a particular part of the brain that secretes several hormones, the hypophysis.
- Trial name
- AcromEnaC (NCT00531908)
- Testing
- furosemide
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Cerebral Infarction
Study of NeuroAid In Enhancing Recovery After Stroke
TIERS is a phase II to generate detailed preliminary data on the efficacy of NeuroAid in post-stroke recovery, and to assess the utility of the rehabilitation outcome measure instruments used.
- Trial name
- TIERS (NCT00721825)
- Testing
- Neuroaid
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Moleac Pte Ltd.
Stroke
Comparison of Innovative Rehabilitation Treatments and Examination of Their Effectiveness in Stroke Patients
We perform a comparison of several groups. We would like to determine how robotic and virtual therapy is most effective in the treatment of stroke patients.
- Trial name
- NCT05985889
- Testing
- Robot, Fizio, EXE1
- Where
- Hungary
- Volunteers
- 75 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Coronary Artery Disease, Brain Injury
Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery
In high-income countries, coronary artery bypass grafting (CABG) remains a common procedure, with approximately 36.7 operations per 100,000 inhabitants annually, corresponding to about 136,000 procedures in the European Union.
- Trial name
- HYPNOCABG (NCT07316868)
- Testing
- Normothermic cardiopulmonary bypass, Hypothermic cardiopulmonary bypass
- Where
- Finland
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Acute Stroke
Endovascular Magnesium Sampling in Acute Stroke
This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients.
- Trial name
- NCT01502748
- Testing
- endovascular sampling
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of Southern California
Embolic Stroke of Undetermined Source, Transient Ischemic Attack
RoBotic TCD Ultrasound BubbLe Study Compared to Transthoracic Echocardiography for Detection of Right to Left Shunt
This study is a multi-center, prospective, single-arm, non-significant risk (NSR) device study in which up to 150 evaluable subjects with suspicion of embolic stroke of undetermined source (ESUS) will be evaluated with NB-IS TCD…
- Conditions
- Embolic Stroke of Undetermined Source, Transient Ischemic Attack, Right-To-Left Atrial Shunt, Patent Foramen Ovale
- Trial name
- BUBL (NCT04604015)
- Testing
- NeuralBot Investigational System, Transthoracic Echocardiography (TTE)
- Where
- 7 sites in United States
- Volunteers
- 154 people
- Sponsor
- NeuraSignal Inc dba NovaSignal
Intracranial Atherosclerosis
Asymptomatic Intracranial Atherosclerotic Disease in Pakistanis
The incidence of stroke has increased by 100% in the last four decades in developing countries like Pakistan. Intracranial atherosclerotic disease (ICAD) is the most frequent causative subtype of ischemic stroke in the world…
- Trial name
- AICAD (NCT02072876)
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people
- Sponsor
- Aga Khan University
Stroke, fMRI
fMRI Neurofeedback for Motor Rehabilitation
Background: People can learn to use feedback about brain activity to change that activity. Researchers want to see if people who have had a stroke can change their brain activity by practice and thought with feedback, and if that…
- Trial name
- NCT02089776
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Artery Injuries, Traumatic Injury
Use of 81 vs 325mg of ASA in Treatment of BCVI
Blunt cerebrovascular injury (BCVI), or injury to the carotid and vertebral arteries, occurs in 1-3% of blunt traumas, often as a result of injury to the head, neck, or chest.
- Conditions
- Carotid Artery Injuries, Traumatic Injury, Vertebral Artery Injury
- Trial name
- NCT06383650
- Testing
- Acetylsalicylic Acid
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre
Stroke, Cardiac Disease
Multifactorial Risk Stratification in Stroke Patients With Cardiac Disease
Prospective registry for multifactorial risk factor assessment, enrolling consecutive ischemic stroke/transient ischemic attack patients with structural, inflammatory, or arrhythmogenic cardiac disease, who are admitted to our…
- Trial name
- NCT04352790
- Volunteers
- 878 people
- Sponsor
- University Hospital Tuebingen
Ischemic Stroke
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval
The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset.
- Trial name
- NCT03494920
- Testing
- Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR
- Where
- 33 sites in Australia, China and 2 more
- Volunteers
- 295 people
- Sponsor
- Neuroscience Trials Australia
Intracranial Atherosclerosis
The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Intracranial Atherosclerotic Stenosis
The purpose of this study is to verify the efficacy and safety of the Intracranial Stent (Tonbridge) in endovascular treatment of intracranial atherosclerotic stenosis.
- Trial name
- NCT05593224
- Testing
- Intracranial Stent (Tonbridge)
- Where
- 14 sites in China
- Volunteers
- 156 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Stroke
Resistance Training and Constrained Induced Movement Therapy on Upper Extremity Motor Recovery and Quality of Life in Sub-acute Stroke Patients
This study explored two common rehabilitation strategies-Constraint-Induced Movement Therapy (CIMT) and Resistance Training (RT)-to help stroke survivors improve movement and function in their weaker arm.
- Trial name
- NCT06933147
- Testing
- Constraint-Induced Movement Therapy (CIMT), Resistance Training (RT)
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
Chronic Stroke Patients
Effects of Vestibular-Oriented Balance Training Versus Motor Dual Task Training on Balance, Postural Control, and Fall Risk in Chronic Stroke Survivors
This randomized controlled trial aims to compare the effectiveness of Vestibular-Oriented Balance Training and Motor Dual Task Training on balance, postural control, and fall risk among chronic stroke survivors.
- Trial name
- NCT07754747
- Testing
- Experimental, Control
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Ibadat International University, Islamabad
HR Vaiability, Aerobic Physical Fitness,Blood Pressure, Blood Sugar Level, Blood HDL, LDL
Aerobic Exercise Training & the Autonomic System In Patients After Myocardial Infarction or Stroke
The purpose of this study is to examine the effect of Aerobic Physical Activity on the function of the Autonomic System in patients after Myocardial Infarction or Stroke.
- Trial name
- NCT00259948
- Testing
- Aerobic exercise training
- Where
- Israel
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Stroke, Acute, Atherosclerosis
Diagnostic and Prognostic Role of Clot Analysis in Stroke Patients
BACKGROUND AND RATIONALE OF THE STUDY The analysis of the composition of the clot constitutes a promising tool for investigating the possible pathogenetic mechanisms underlying ischemic stroke.
- Conditions
- Stroke, Acute, Atherosclerosis, Atrial Fibrillation
- Trial name
- DICAS (NCT05760326)
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke, Ischemic
BIC: Evaluation of the Current Care Processes for Stroke Care in Flemish Hospitals
Different studies showed large variation between care processes in multiple diseases, which lead to large variation in outcomes.
- Trial name
- NCT05218135
- Testing
- Intervention
- Where
- Belgium
- Volunteers
- 2,610 people
- Sponsor
- KU Leuven