Clinical trials: Cerebrovascular Accident, Acute
Acute Ischemic Stroke
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy
Acute ischemic stroke caused by blockage of a large brain artery can lead to severe disability. Endovascular thrombectomy is a catheter-based procedure used to remove the blood clot and restore blood flow.
- Trial name
- CARE-EVT (NCT06339411)
- Testing
- Cerebrolysin
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute
The Temporal Cellular Landscape of the Adaptive Immune System in Patients With Acute Stroke
Despite novel acute therapies the global burden of stroke remains high worldwide. Targeting the immune response after stroke has the potential to improve recovery in all stroke patients.
- Trial name
- TAPAS (NCT04852445)
- Where
- Netherlands
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Ischemic Stroke
Combination of the Immune Modulator Dimethyl Fumarate With Alteplase in Acute Ischemic Stroke
The investigators conduct this study to investigate whether oral administration of Dimethyl Fumarate, a Food and Drug Administration-approved drug for multiple sclerosis, is safe and effective in combination with alteplase in…
- Trial name
- NCT04890366
- Testing
- Dimethyl Fumarate
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Stroke
PG2 Injection 500 mg in Acute Stroke Study (Pass)
The primary objective of this study is to evaluate the efficacy of PG2 Injection 500 mg versus placebo, administered intravenously within 3-6 hrs of stroke onset to patients with an acute ischemic stroke, as determined by…
- Trial name
- Pass (NCT01603667)
- Testing
- PG2
- Where
- Taiwan
- Volunteers
- 86 people
- Sponsor
- China Medical University Hospital
Stroke, Acute Ischemic
Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human tenecteplase (rhTNK-tPA) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT06987305
- Testing
- Intravenous rhTNK-tPA, Endovascular thrombectomy
- Where
- 4 sites in China
- Volunteers
- 820 people
- Sponsor
- Xinqiao Hospital of Chongqing
Ischemic Stroke, Acute, Ischemic Stroke
TeleStroke-Guided Thrombolysis for Acute Ischemic Stroke in Oman
The goal of this study is to establish and examine the efficacy of using a Telestroke network in Oman to facilitate using emergent thrombolysis for patients with acute ischemic stroke encountered in selected peripheral hospitals.
- Trial name
- NCT07721129
- Testing
- alteplase or tenecteplase
- Volunteers
- 200 people
- Sponsor
- Oman Ministry of Health
Acute Ischemic Stroke
Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel…
- Trial name
- NCT05845372
- Where
- 19 sites in China
- Volunteers
- 2,592 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Stroke, Acute, Stroke, Ischemic
Trustworthy Artificial Intelligence for Improvement of Stroke Outcomes
Stroke is a leading cause of death and disability worldwide. The clinical validation of explainable and interpretable Artificial Intelligence (AI) solutions to assist a timely, personalised management of the acute phase of…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- TRUSTroke (NCT06710028)
- Testing
- NORA
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke
Improving Post-acute Stroke Follow-up Care by Adopting Telecare Consultations in a Nurse-led Clinic
Since 2017, Hong Kong has provided post-acute stroke services in clinics operated by stroke advanced practice nurses (APNs). Currently, the applicability of the clinics has been further limited by the emergence of the coronavirus…
- Trial name
- NCT05183672
- Testing
- Telecare consultation, Usual face-to-face consultation
- Where
- Hong Kong
- Volunteers
- 196 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Acute
Evaluation of Diagnostic Performance of Cerebral Perfusion Scans in Pseudo-Stroke
When a patient is received with the context of acute stroke, they undergo a fast neurological evaluation and obtain a basic appraisal composed of a non-contrast endovascular cerebral scan and an angiography scan of intracranial…
- Trial name
- CTP (NCT04105257)
- Testing
- All patients
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Stroke, Ischemic
The Assessment of Acute /Chronic Phase in Patients With Ischemic Cerebral Stroke Using TCM Diagnostic Tools
Cerebral infarction is the second cause of death and the third cause of disability. More than 13.7 million patients worldwide are diagnosed with stroke every year, and the number of deaths is 5.5 million, of which ischemic stroke…
- Trial name
- NCT06342206
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- China Medical University Hospital
Ischemic Stroke
Ticagrelor Versus Cilostazol in Minor Ischemic Stroke or TIA
Along with the current clinical trial, the efficacy and safety of ticagrelor and aspirin administered within the first 24 hours of first-ever ischemic stroke compared to cilostazol and aspirin were assessed through NIHSS, mRS…
- Trial name
- NCT06196047
- Testing
- Ticagrelor 90 MG, Cilostazol 100 MG
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Acute Ischemic Stroke
PROMISE: PRedictors Of Good outcoMes in Thrombectomy for Large Infarct Core Stroke Evaluation
Identify the factors associated with a favorable clinical outcome in participants with acute ischemic stroke and large core infarcts within 24 hours of onset who are treated with endovascular intervention.
- Trial name
- NCT06016348
- Testing
- Endovascular treatment
- Where
- 4 sites in Vietnam
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Ischemic Stroke
Efficacy of BNG-1 to Treat Acute Ischemic Stroke
The objective of this study is to investigate the efficacy and safety of BNG-1 in patients with ischemic stroke. The efficacy assessment will be based on the functional outcome while the safety will be reviewed by the adverse…
- Trial name
- BNG-1 (NCT01675115)
- Testing
- BNG-1, Aspirin
- Where
- Taiwan
- Volunteers
- 129 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
A Prospective Investigation of the VWF-ADAMTS 13 Axis in Acute Ischaemic Brain Injury (TIAs and Stroke).
In patients presenting with acute stroke or transient ischaemic attacks (TIA), von Willebrand factor related parameters, including VWF antigen, activity, FVIII:c and propeptides, ADAMTS13 levels and VWF multimers in cases where…
- Trial name
- NCT02219035
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Stroke
Muscle Trajectories in Acute Stroke Patients
The aim of this study is to explore time-related trajectories of muscle alterations and inflammation in acute hospitalized stroke patients.
- Trial name
- NCT04337411
- Testing
- Follow-up assessments
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Vrije Universiteit Brussel
Acute Stroke, Transient Ischemic Attack
Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis
Large-artery stenosis plays an important role in the occurrence of ischemic stroke. The primary purpose of this study is to evaluate the efficacy and safety of intensive antiplatelet therapy versus standard antiplatelet therapy…
- Trial name
- INSPIRES (NCT03635749)
- Testing
- Intensive antiplatelet, Standard antiplatelet, Immediate high-intensity statin
- Where
- 113 sites in China
- Volunteers
- 6,100 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Safety Study of External Counterpulsation as a Treatment for Acute Ischemic Stroke
The purpose of this study is to determine if external counterpulsation (ECP) is feasible to perform, tolerable, and safe as a treatment for patients with acute ischemic stroke (i.e., a blockage of one of the arteries supplying a…
- Trial name
- CUFFS (NCT00983749)
- Testing
- Full-pressure ECP
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Ischemic Stroke or High-risk TIA (ABCD² ≥ 4)
INtensive liPid-lowering Therapy for Acute High-risk IntracRanial or Extracranial atheroSclerosis -II (INSPIRES-2)
The research team is conducting a randomized, double-blind, placebo-controlled, multicenter clinical study aimed at evaluating the impact of adding Tolecilimab (a PCSK9 inhibitor) to standard lipid-lowering therapy (statins ±…
- Trial name
- NCT07341958
- Testing
- Tafolecimab
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Randomized a Clinical Trial With Medical Device in Acute Ischemic Stroke
This study seeks to provide high-quality evidence on the potential benefits of the dual stentriever approach, potentially informing future clinical guidelines and improving outcomes in patients with anterior circulation large…
- Trial name
- DOBLE UP (NCT07113184)
- Testing
- dual sr, single sr
- Where
- 3 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
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